EC Number   |
Protein Variants |
Reference |
|---|
    1.3.98.1 | C130A |
low activity with dihydroorotate, increasing activity above pH 8.0 with dihydrooxonate |
390913 |
| 1.3.98.1 | S175A |
low activity with dihydroorotate, increasing activity above pH 8.0 with dihydrooxonate |
390913 |
| 1.3.98.1 | L71F/V133T |
reaction is drastically slower forwith wild-type, Kd for dihydroorotate is iabout eight-fold tighter than the wild-type |
724305 |
| 1.3.98.1 | L71F |
reaction is somehow slower than for wild-type, binding of dihydroorotate is much tighter than with wild-type |
724305 |
| 1.3.98.1 | V133T |
reaction is somehow slower than for wild-type, binding of dihydroorotate is much weaker than with wild-type |
724305 |
| 1.3.98.1 | N127A |
reduced activity |
656148 |
| 1.3.98.1 | Q7L |
single nucleotide polymorphism due to missense polymorphism 19C>A, leading to amino acid substitution in the cationic N-terminal region of the polypeptide |
700606 |
| 1.3.98.1 | C130A |
the mutant enzyme exhibits binding affinities for dihydroorotate similar to that of the wild type enzyme, reduction is extremely slow compared to that of the wild type, the rate of reduction increases with pH showing no sign of a plateau |
685146 |
| 1.3.98.1 | C130S |
the mutant enzyme exhibits binding affinities for dihydroorotate similar to that of the wild type enzyme, reduction is extremely slow compared to that of the wild type, the rate of reduction increases with pH showing no sign of a plateau |
685146 |
| 1.3.98.1 | C130A |
the mutant forms charge-transfer complexes upon binding 3,4-dihydroxybenzoate, but the maximum of the broad charge-transfer bands is shifted to 590 nm |
685158 |
