EC Number |
Protein Variants |
Reference |
---|
1.3.98.1 | N67A |
drastically reduced activiy |
656148 |
1.3.98.1 | P131A |
decrease in activtiy against fumarate |
656148 |
1.3.98.1 | P56A |
drastically reduced activiy |
656148 |
1.3.98.1 | Q7L |
single nucleotide polymorphism due to missense polymorphism 19C>A, leading to amino acid substitution in the cationic N-terminal region of the polypeptide |
700606 |
1.3.98.1 | R265A |
2fold increase in KM-value of CoQD, 15% increase in KM-value of L-dihydroorotate |
656285 |
1.3.98.1 | R50E |
little changes in activity |
656148 |
1.3.98.1 | R57A |
increase in activity |
656148 |
1.3.98.1 | S129A |
decrease in activtiy against fumarate |
656148 |
1.3.98.1 | S175A |
- |
390913 |
1.3.98.1 | S175A |
low activity with dihydroorotate, increasing activity above pH 8.0 with dihydrooxonate |
390913 |