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<< < Results 11 - 20 of 31 > >>
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EC Number Protein Variants Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47E446V mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E446 which partly stabilizes the complex C3bB(Mg2+) thereby inhibiting activation of the proenzyme 717849
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47K294A mutation in the Bb component decreases sensitivity to CR1 to 44% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47E434A mutation in the Bb component decreases sensitivity to CR1 to 65% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47D445A mutation in the Bb component decreases sensitivity to CR1 to 71% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47K265A/K266A Mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 18% of the wild-type value and sensitivity to Factor H to 19% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47Y338F mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 20% of the wild-type value and sensitivity to Factor H to 61% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47Q335A mutation in the Bb component decreases sensitivity to DAF to 20% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47N260D mutation in the Bb component decreases sensitivity to DAF to 32% of the wild-type value, sensitivity to CR1 to 31% of the wild-type value and sensitivity to Factor H to 24% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47S339A mutation in the Bb component decreases sensitivity to DAF to 32% of the wild-type value, sensitivity to CR1 to 50% of the wild-type value 652225
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.47D382A mutation in the Bb component decreases sensitivity to DAF to 36% of the wild-type value, sensitivity to CR1 to 41% of the wild-type value 652225
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