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<< < Results 11 - 20 of 31 > >>
EC Number
Amino acid exchange
Commentary
Reference
E207A
mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E207, with little effects on the cleavage of proenzyme factor B
E301A
mutation in the Bb component decreases sensitivity to DAF to 75% of the wild-type value
E316A
mutation in the Bb component decreases sensitivity to DAF to 71% of the wild-type value
E379A
mutation in the Bb component decreases sensitivity to DAF to 52% of the wild-type value, sensitivity to CR1 to 50% of the wild-type value
E434A
mutation in the Bb component decreases sensitivity to CR1 to 65% of the wild-type value
E446V
mutation in proenzyme factor B. Mutation disrupts salt bridge R234-E446 which partly stabilizes the complex C3bB(Mg2+) thereby inhibiting activation of the proenzyme
F716A
factor B mutation, severly reduces hemolytic activity
K265A/K266A
Mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 18% of the wild-type value and sensitivity to Factor H to 19% of the wild-type value
K294A
mutation in the Bb component decreases sensitivity to CR1 to 44% of the wild-type value
M341A
mutation in the Bb component decreases sensitivity to Factor H to 75% of the wild-type value
<< < Results 11 - 20 of 31 > >>