EC Number   |
Protein Variants |
Reference |
|---|
   3.1.3.56 | F392A |
50% of activity |
646400 |
| 3.1.3.56 | H184A |
traces of activity |
646400 |
| 3.1.3.56 | H219A |
site-directed mutagenesis, mutation in the P-loop/alpha-helix4, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview |
751120 |
| 3.1.3.56 | H385A |
no activity |
646400 |
| 3.1.3.56 | H730A |
no activity |
646400 |
| 3.1.3.56 | K184A |
site-directed mutagenesis, mutation in the Flex-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview |
-, 751120 |
| 3.1.3.56 | K218A |
site-directed mutagenesis, mutation in the P-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview |
751120 |
| 3.1.3.56 | K250A |
site-directed mutagenesis, mutation in the alpha4-alpha5-loop, the mutant shows altered substrate specificities and activities compared to the wild-type enzyme, overview |
751120 |
| 3.1.3.56 | K386A |
no activity |
646400 |
| 3.1.3.56 | more |
construction of transgenic Arabidopsis thaliana plants expressing the human enzyme, the transgenic plants show no altered growth and life cycle phenotype although the basal level of inositol 1,4,5-trisphosphate is reduced by 90% compared to wild-type plants, but the plants are insensitive to gravitropic stimulation and show no increased InsP3 levels in inflorescence stem under gravistimulation in contrast to wild-type plants, bending responses, overview |
666645 |
