EC Number |
Protein Variants |
Reference |
---|
2.6.1.5 | C151Y |
missense mutation leading to defective folding and likely alteration of the enzymatic activity |
676025 |
2.6.1.5 | I249A |
reduced catalytic activity |
673540 |
2.6.1.5 | L273P |
missense mutation leading to defective folding and likely alteration of the enzymatic activity |
676025 |
2.6.1.5 | more |
switch of aspartate aminotransferase to use of tyrosine substrate by introduction of six mutations obtained by rational design and termed HEX plus mutation A293D or mutation I73V |
660463 |
2.6.1.5 | N17S |
increase in Km-values, substantial decrease in kcat-values |
660454 |
2.6.1.5 | N54S |
reduced enzymic activity |
660454 |
2.6.1.5 | R20A |
increase in Km-values, substantial decrease in kcat-values |
660454 |
2.6.1.5 | R315K |
retains enzymic activity |
660454 |
2.6.1.5 | R417Q |
no enzymic activity |
660454 |
2.6.1.5 | R41A |
mutant is inactive when tested with (S)-beta-phenylalanine as amino donor and 2-oxoglutarate as amino acceptor |
721359 |