EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
6.3.4.21 | Bone Marrow Failure Disorders |
32098966 |
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. |
unassigned |
0 |
6.3.4.21 | Carcinoma |
24204194 |
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. |
diagnostic usage ongoing research therapeutic application unassigned |
3 2 3 0 |
6.3.4.21 | Carcinoma, Non-Small-Cell Lung |
24204194 |
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. |
diagnostic usage ongoing research therapeutic application unassigned |
3 2 3 0 |
6.3.4.21 | Glioblastoma |
19703994 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 1 1 4 |
6.3.4.21 | Glioblastoma |
22570471 |
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. |
causal interaction therapeutic application unassigned |
3 1 0 |
6.3.4.21 | Glioma |
33197538 |
NAD+ depletion radiosensitizes 2-DG-treated glioma cells by abolishing metabolic adaptation. |
causal interaction therapeutic application unassigned |
2 1 0 |
6.3.4.21 | Glucose Intolerance |
27592202 |
Tissue-specific regulation of sirtuin and nicotinamide adenine dinucleotide biosynthetic pathways identified in C57Bl/6 mice in response to high-fat feeding. |
causal interaction unassigned |
3 0 |
6.3.4.21 | Lymphoma |
21492230 |
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 3 4 4 |
6.3.4.21 | Neoplasms |
19703994 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. |
causal interaction diagnostic usage ongoing research therapeutic application |
4 1 1 4 |
6.3.4.21 | Neoplasms |
20515945 |
A preclinical study on the rescue of normal tissue by nicotinic acid in high-dose treatment with APO866, a specific nicotinamide phosphoribosyltransferase inhibitor. |
causal interaction therapeutic application unassigned |
4 4 0 |