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Results 1 - 10 of 134 > >>
EC Number Disease PubMed ID Title of Publication Category Confidence Level
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Alzheimer Disease 12694406 ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. causal interaction
therapeutic application
unassigned
3
4
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Alzheimer Disease 14557245 APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. causal interaction
unassigned
4
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Alzheimer Disease 20827337 Amyloid Precursor Protein Binding Protein-1 Is Up-regulated in Brains of Tg2576 Mice. causal interaction
ongoing research
unassigned
4
4
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Alzheimer Disease 32579500 Melatonin Prevents Neddylation Dysfunction in A?42-Exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor Protein- Binding Protein 1 Pathway. causal interaction
unassigned
1
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Breast Neoplasms 22457814 The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. ongoing research
therapeutic application
unassigned
3
4
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Breast Neoplasms 30198810 AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. therapeutic application
unassigned
4
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Breast Neoplasms 32360865 Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1. ongoing research
therapeutic application
unassigned
2
1
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Carcinogenesis 24213570 Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. causal interaction
therapeutic application
unassigned
3
2
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Carcinogenesis 28468780 Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. causal interaction
ongoing research
therapeutic application
unassigned
4
1
3
0
Display the word mapDisplay the reaction diagram Show all sequences 6.2.1.64Carcinogenesis 33547247 Correction: Combined Inhibition of NEDD8-activating Enzyme and mTOR Suppresses NF2 Loss-driven Tumorigenesis. causal interaction
therapeutic application
unassigned
2
2
0
Results 1 - 10 of 134 > >>