EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
6.2.1.64 | Alzheimer Disease |
12694406 |
ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. |
causal interaction therapeutic application unassigned |
3 4 0 |
6.2.1.64 | Alzheimer Disease |
14557245 |
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. |
causal interaction unassigned |
4 0 |
6.2.1.64 | Alzheimer Disease |
20827337 |
Amyloid Precursor Protein Binding Protein-1 Is Up-regulated in Brains of Tg2576 Mice. |
causal interaction ongoing research unassigned |
4 4 0 |
6.2.1.64 | Alzheimer Disease |
32579500 |
Melatonin Prevents Neddylation Dysfunction in A?42-Exposed SH-SY5Y Neuroblastoma Cells by Regulating the Amyloid Precursor Protein- Binding Protein 1 Pathway. |
causal interaction unassigned |
1 0 |
6.2.1.64 | Breast Neoplasms |
22457814 |
The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. |
ongoing research therapeutic application unassigned |
3 4 0 |
6.2.1.64 | Breast Neoplasms |
30198810 |
AKT inhibitor MK-2206 sensitizes breast cancer cells to MLN4924, a first-in-class NEDD8-activating enzyme (NAE) inhibitor. |
therapeutic application unassigned |
4 0 |
6.2.1.64 | Breast Neoplasms |
32360865 |
Nedd8-activating enzyme inhibitor MLN4924 (Pevonedistat), inhibits miR-1303 to suppress human breast cancer cell proliferation via targeting p27Kip1. |
ongoing research therapeutic application unassigned |
2 1 0 |
6.2.1.64 | Carcinogenesis |
24213570 |
Endothelial deletion of Sag/Rbx2/Roc2 E3 ubiquitin ligase causes embryonic lethality and blocks tumor angiogenesis. |
causal interaction therapeutic application unassigned |
3 2 0 |
6.2.1.64 | Carcinogenesis |
28468780 |
Combined Inhibition of NEDD8-Activating Enzyme and mTOR Suppresses NF2 Loss-Driven Tumorigenesis. |
causal interaction ongoing research therapeutic application unassigned |
4 1 3 0 |
6.2.1.64 | Carcinogenesis |
33547247 |
Correction: Combined Inhibition of NEDD8-activating Enzyme and mTOR Suppresses NF2 Loss-driven Tumorigenesis. |
causal interaction therapeutic application unassigned |
2 2 0 |