EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.23.45 | Alzheimer Disease |
10931940 |
BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein. |
causal interaction
unassigned |
3
0 |
| 3.4.23.45 | Alzheimer Disease |
10965118 |
A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase. |
causal interaction
unassigned |
4
0 |
| 3.4.23.45 | Alzheimer Disease |
11032903 |
Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 3.4.23.45 | Alzheimer Disease |
11714100 |
Mutations in the open reading frame of the beta-site APP cleaving enzyme (BACE) locus are not a common cause of Alzheimer's disease. |
causal interaction
unassigned |
4
0 |
| 3.4.23.45 | Alzheimer Disease |
12093293 |
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.23.45 | Alzheimer Disease |
12423367 |
Enzymic properties of recombinant BACE2. |
unassigned |
0 |
| 3.4.23.45 | Alzheimer Disease |
12535780 |
The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease. |
causal interaction
unassigned |
4
0 |
| 3.4.23.45 | Alzheimer Disease |
12707937 |
Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
1
2
0 |
| 3.4.23.45 | Alzheimer Disease |
15473697 |
Insights from modeling the tertiary structure of human BACE2. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.23.45 | Alzheimer Disease |
15492223 |
A system for enhancing genome-wide coexpression dynamics study. |
diagnostic usage
unassigned |
3
0 |
