EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.23.36 | Alzheimer Disease |
33637690 |
Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease. |
unassigned |
0 |
| 3.4.23.36 | Arthritis, Psoriatic |
32198923 |
Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis. |
diagnostic usage
ongoing research
unassigned |
2
4
0 |
| 3.4.23.36 | Arthritis, Rheumatoid |
32198923 |
Impaired proteolysis by SPPL2a causes CD74 fragment accumulation that can be recognized by anti-CD74 autoantibodies in human ankylosing spondylitis. |
diagnostic usage
ongoing research
unassigned |
2
4
0 |
| 3.4.23.36 | Autoimmune Diseases |
28731783 |
Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 3.4.23.36 | Autoimmune Diseases |
29359565 |
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. |
causal interaction
therapeutic application
unassigned |
1
4
0 |
| 3.4.23.36 | Autoimmune Diseases |
33152005 |
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship. |
diagnostic usage
therapeutic application
unassigned |
3
1
0 |
| 3.4.23.36 | Ehrlichiosis |
18490460 |
Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
| 3.4.23.36 | Frontotemporal Lobar Degeneration |
24872421 |
Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a). |
diagnostic usage
unassigned |
1
0 |
| 3.4.23.36 | Glioblastoma |
27641332 |
ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA. |
unassigned |
0 |
| 3.4.23.36 | Infections |
18490460 |
Proteomic analysis of and immune responses to Ehrlichia chaffeensis lipoproteins. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
