EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.22.B70 | Astrocytoma |
27693211 |
Inhibition of SUMO-specific protease 1 induces apoptosis of astroglioma cells by regulating NF-?B/Akt pathways. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
4 |
| 3.4.22.B70 | Breast Neoplasms |
23338788 |
Exploring the association between genetic variation in the SUMO isopeptidase gene USPL1 and breast cancer through integration of data from the population-based GENICA study and external genetic databases. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 3.4.22.B70 | Burkitt Lymphoma |
22901169 |
Down-regulation of SENP1 Expression Increases Apoptosis of Burkitt Lymphoma Cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
4
0 |
| 3.4.22.B70 | Carcinogenesis |
27446366 |
Melatonin downregulates nuclear receptor RZR/ROR? expression causing growth-inhibitory and anti-angiogenesis activity in human gastric cancer cells in vitro and in vivo. |
therapeutic application
unassigned |
1
0 |
| 3.4.22.B70 | Cardiomyopathies |
25128087 |
SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
3
0 |
| 3.4.22.B70 | Colonic Neoplasms |
21669491 |
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. |
causal interaction
ongoing research
unassigned |
4
4
0 |
| 3.4.22.B70 | Colorectal Neoplasms |
28748780 |
MiR-133a-3p Targets SUMO-Specific Protease 1 to Inhibit Cell Proliferation and Cell Cycle Progress in Colorectal Cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
2
3
1 |
| 3.4.22.B70 | Heart Failure |
34447469 |
Astragaloside IV alleviates heart failure by regulating SUMO-specific protease 1. |
ongoing research
unassigned |
4
0 |
| 3.4.22.B70 | Keloid |
32474020 |
Sumoylation enhances the activity of the TGF-?/SMAD and HIF-1 signaling pathways in keloids. |
diagnostic usage
ongoing research
unassigned |
3
3
0 |
| 3.4.22.B70 | Leukemia |
27895727 |
Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
1
2
0 |
