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EC Number Disease PubMed ID Title of Publication Category Confidence Level
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.533',5'-cyclic-amp phosphodiesterase deficiency 16213210 Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. causal interaction
therapeutic application
unassigned
4
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.533',5'-cyclic-amp phosphodiesterase deficiency 19359377 Reduced adiposity and high fat diet-induced adipose inflammation in mice deficient for phosphodiesterase 4B. causal interaction
therapeutic application
unassigned
4
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.533',5'-cyclic-amp phosphodiesterase deficiency 25457552 Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice. ongoing research
unassigned
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.533',5'-cyclic-amp phosphodiesterase deficiency 32264695 Cardiac Overexpression of PDE4B Blunts ?-Adrenergic Response and Maladaptive Remodeling in Heart Failure. causal interaction
therapeutic application
unassigned
4
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acquired Immunodeficiency Syndrome 31231579 Novel GFP-fused protein probes for detecting phosphatidylinositol-4-phosphate in the plasma membrane. unassigned 0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acute Kidney Injury 32622666 Rutaecarpine derivative Cpd-6c alleviates acute kidney injury by targeting PDE4B, a key enzyme mediating inflammation in cisplatin nephropathy. therapeutic application
unassigned
1
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acute Lung Injury 9490659 Suppression of acute lung injury in mice by an inhibitor of phosphodiesterase type 4. ongoing research
therapeutic application
unassigned
3
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acute Lung Injury 10806144 Additive effects of phosphodiesterase-4 inhibition on effects of rSP-C surfactant. ongoing research
therapeutic application
unassigned
3
4
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acute Lung Injury 11907182 The selective phosphodiesterase 4 inhibitor RP 73-401 reduced matrix metalloproteinase 9 activity and transforming growth factor-beta release during acute lung injury in mice: the role of the balance between Tumor necrosis factor-alpha and interleukin-10. causal interaction
therapeutic application
unassigned
3
1
0
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.53Acute Lung Injury 12882446 Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury. causal interaction
diagnostic usage
ongoing research
therapeutic application
4
3
3
4
Results 1 - 10 of 1266 > >>