EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.1.3.69 | Acute Lung Injury |
33729030 |
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.1.3.69 | Adenocarcinoma of Lung |
29377583 |
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
4
2 |
| 3.1.3.69 | Angiomyolipoma |
30675208 |
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
3
4 |
| 3.1.3.69 | Bone Diseases |
23919676 |
Moiety-Linkage Map Reveals Selective Nonbisphosphonate Inhibitors of Human Geranylgeranyl Diphosphate Synthase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 3.1.3.69 | Cardiomegaly |
25385233 |
The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure. |
ongoing research
unassigned |
1
0 |
| 3.1.3.69 | Diabetes Mellitus, Type 2 |
26112408 |
Lipid-induced Muscle Insulin Resistance Is Mediated by GGPPS via Modulation of the RhoA/Rho Kinase Signaling Pathway. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
4
0 |
| 3.1.3.69 | glucosylglycerol 3-phosphatase deficiency |
25819439 |
GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis. |
causal interaction
unassigned |
4
0 |
| 3.1.3.69 | glucosylglycerol 3-phosphatase deficiency |
29971772 |
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
2
3
1
0 |
| 3.1.3.69 | glucosylglycerol 3-phosphatase deficiency |
31120854 |
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-?1/BMP-4 signaling. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
4
0 |
| 3.1.3.69 | glucosylglycerol 3-phosphatase deficiency |
33729030 |
Geranylgeranyl diphosphate synthase deficiency hyperactivates macrophages and aggravates lipopolysaccharide-induced acute lung injury. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
