EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.11.4 | Breast Neoplasms |
34526485 |
Inhibiting BCKDK in triple negative breast cancer suppresses protein translation, impairs mitochondrial function, and potentiates doxorubicin cytotoxicity. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 2.7.11.4 | Carcinogenesis |
28501528 |
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
2
1
0 |
| 2.7.11.4 | Carcinoma, Hepatocellular |
10989456 |
Regulation of branched-chain alpha-keto acid dehydrogenase kinase gene expression by glucocorticoids in hepatoma cells and rat liver. |
ongoing research
unassigned |
4
0 |
| 2.7.11.4 | Carcinoma, Hepatocellular |
32457292 |
APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway. |
diagnostic usage
unassigned |
1
0 |
| 2.7.11.4 | Colorectal Neoplasms |
28501528 |
BCKDK of BCAA Catabolism Cross-talking With the MAPK Pathway Promotes Tumorigenesis of Colorectal Cancer. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
2
1
0 |
| 2.7.11.4 | Colorectal Neoplasms |
32238881 |
Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
2
1 |
| 2.7.11.4 | Diabetes Mellitus |
20138840 |
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. |
diagnostic usage
ongoing research
unassigned |
1
4
0 |
| 2.7.11.4 | Diabetes Mellitus, Type 2 |
20138840 |
Regulation of hepatic branched-chain alpha-keto acid dehydrogenase kinase in a rat model for type 2 diabetes mellitus at different stages of the disease. |
diagnostic usage
ongoing research
unassigned |
1
4
0 |
| 2.7.11.4 | Epilepsy |
22956686 |
Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy. |
causal interaction
unassigned |
4
0 |
| 2.7.11.4 | Hepatitis |
28597552 |
Branched chain ?-ketoacid dehydrogenase kinase 111-130, a T cell epitope that induces both autoimmune myocarditis and hepatitis in A/J mice. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
2
3
3
0 |
