EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
2.7.11.16 | Adenocarcinoma of Lung |
30984536 |
Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBP?, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. |
causal interaction diagnostic usage ongoing research unassigned |
4 3 2 0 |
2.7.11.16 | Alzheimer Disease |
18955119 |
Augmented axonal defects and synaptic degenerative changes in female GRK5 deficient mice. |
causal interaction unassigned |
4 0 |
2.7.11.16 | Alzheimer Disease |
19478075 |
GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. |
causal interaction therapeutic application unassigned |
4 2 0 |
2.7.11.16 | Alzheimer Disease |
21041302 |
GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. |
unassigned |
0 |
2.7.11.16 | Alzheimer Disease |
24598771 |
GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. |
causal interaction unassigned |
4 0 |
2.7.11.16 | Aortic Coarctation |
28106155 |
Secreted miR-27a Induced by Cyclic Stretch Modulates the Proliferation of Endothelial Cells in Hypertension via GRK6. |
causal interaction unassigned |
2 0 |
2.7.11.16 | Arthritis |
34006987 |
G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis. |
unassigned |
0 |
2.7.11.16 | Atrial Fibrillation |
25049040 |
G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving ?-blockers. |
causal interaction diagnostic usage therapeutic application unassigned |
3 1 2 0 |
2.7.11.16 | Breast Neoplasms |
18767025 |
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. |
causal interaction diagnostic usage ongoing research unassigned |
3 1 2 0 |
2.7.11.16 | Carcinogenesis |
18767025 |
Expression of G protein-coupled receptor kinase 4 is associated with breast cancer tumourigenesis. |
causal interaction diagnostic usage ongoing research unassigned |
3 1 2 0 |