EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.5.1.59 | Arthritis |
21266780 |
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
1
0 |
| 2.5.1.59 | Arthritis, Rheumatoid |
21266780 |
Geranylgeranyltransferase type I (GGTase-I) deficiency hyperactivates macrophages and induces erosive arthritis in mice. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
3
1
0 |
| 2.5.1.59 | Arthritis, Rheumatoid |
23334894 |
Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 2.5.1.59 | Arthritis, Rheumatoid |
31484924 |
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. |
causal interaction
ongoing research
unassigned |
2
2
0 |
| 2.5.1.59 | Asthma |
20074456 |
GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.5.1.59 | Asthma |
20383034 |
Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin. |
therapeutic application
unassigned |
1
0 |
| 2.5.1.59 | Atherosclerosis |
19537691 |
Discovery of geranylgeranyltransferase-I inhibitors with novel scaffolds by the means of quantitative structure-activity relationship modeling, virtual screening, and experimental validation. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.5.1.59 | Atherosclerosis |
23334894 |
Targeting GGTase-I Activates RHOA, Increases Macrophage Reverse Cholesterol Transport, and Reduces Atherosclerosis in Mice. |
causal interaction
ongoing research
unassigned |
3
2
0 |
| 2.5.1.59 | Atherosclerosis |
32851097 |
Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.5.1.59 | Blindness |
29932012 |
Choroideremia: molecular mechanisms and development of AAV gene therapy. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
2
1
0 |
