EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    2.5.1.16 | Brain Neoplasms |
3928144 |
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells. |
ongoing research
therapeutic application
unassigned |
3
1
0 |
| 2.5.1.16 | Breast Neoplasms |
26277788 |
Targeting polyamine biosynthetic pathway through RNAi causes the abrogation of MCF 7 breast cancer cell line. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
2
4
1
0 |
| 2.5.1.16 | Carcinoma |
7332714 |
Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase. |
ongoing research
therapeutic application
unassigned |
2
1
0 |
| 2.5.1.16 | Carcinoma, Hepatocellular |
4005290 |
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
2
4
1
0 |
| 2.5.1.16 | Carcinoma, Hepatocellular |
7608122 |
Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases. |
ongoing research
unassigned |
4
0 |
| 2.5.1.16 | Carcinoma, Hepatocellular |
9020892 |
Inhibition of spermidine synthase gene expression by transforming growth factor-beta 1 in hepatoma cells. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
3
3
0 |
| 2.5.1.16 | Chagas Disease |
12653650 |
Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. |
unassigned |
0 |
| 2.5.1.16 | Chagas Disease |
26881725 |
An NMR Biochemical Assay for Fragment-Based Drug Discovery: Evaluation of an Inhibitor Activity on Spermidine Synthase of Trypanosoma cruzi. |
causal interaction
unassigned |
2
0 |
| 2.5.1.16 | Chagas Disease |
28751689 |
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. |
therapeutic application
unassigned |
4
0 |
| 2.5.1.16 | Cysts |
19965964 |
Arabidopsis spermidine synthase is targeted by an effector protein of the cyst nematode Heterodera schachtii. |
therapeutic application
unassigned |
1
0 |
