EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    2.5.1.10 | Alzheimer Disease |
24911527 |
Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: implications to drug discovery for neurodegenerative diseases. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 2.5.1.10 | Atherosclerosis |
28339090 |
Inhibition of farnesyl pyrophosphate synthase attenuates high glucose?induced vascular smooth muscle cells proliferation. |
causal interaction
unassigned |
1
0 |
| 2.5.1.10 | Bone Diseases |
16892359 |
Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs. |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 2.5.1.10 | Bone Diseases |
17905588 |
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
3
4
0 |
| 2.5.1.10 | Bone Diseases |
20711197 |
Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.5.1.10 | Bone Diseases |
23998921 |
Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition. |
ongoing research
therapeutic application
unassigned |
3
4
0 |
| 2.5.1.10 | Bone Diseases |
26381451 |
Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.5.1.10 | Bone Diseases |
28208018 |
Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 2.5.1.10 | Bone Diseases |
29080272 |
3D-QSAR, molecular docking, and ONIOM studies on the structure-activity relationships and action mechanism of nitrogen-containing bisphosphonates. |
therapeutic application
unassigned |
1
0 |
| 2.5.1.10 | Bone Diseases |
32537808 |
Fragment-Based Discovery of Non-bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase. |
therapeutic application
unassigned |
4
0 |
