EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    2.3.1.241 | Arthritis |
21088052 |
Neisseria meningitidis lipid A mutant LPSs function as LPS antagonists in humans by inhibiting TLR 4-dependent cytokine production. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 2.3.1.241 | Exanthema |
19390612 |
Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
1 |
| 2.3.1.241 | Hepatitis B |
18982519 |
Enhancement of T-helper type I immune responses against hepatitis B surface antigen by LPS derivatives adjuvanted liposomes delivery system. |
diagnostic usage
ongoing research
unassigned |
3
2
0 |
| 2.3.1.241 | Infections |
20439476 |
The structure of Neisseria meningitidis lipid A determines outcome in experimental meningococcal disease. |
ongoing research
therapeutic application
unassigned |
2
2
0 |
| 2.3.1.241 | Influenza, Human |
19059296 |
Incorporation of LpxL1, a detoxified lipopolysaccharide adjuvant, in influenza H5N1 virosomes increases vaccine immunogenicity. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
3
2
3 |
| 2.3.1.241 | Meningitis |
22261040 |
Invasive meningococcal capsular group y disease, England and Wales, 2007-2009. |
causal interaction
diagnostic usage
unassigned |
1
2
0 |
| 2.3.1.241 | Meningitis, Meningococcal |
19390612 |
Naturally occurring lipid A mutants in neisseria meningitidis from patients with invasive meningococcal disease are associated with reduced coagulopathy. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
1 |
| 2.3.1.241 | Meningococcal Infections |
28024455 |
The Neisseria meningitidis lpxL1 mutant induces less tissue factor expression and activity in primary human monocytes and monocyte-derived microvesicles than the wild type meningococcus. |
ongoing research
unassigned |
1
0 |
| 2.3.1.241 | Meningococcal Infections |
29313733 |
Whole-blood incubation with the Neisseria meningitidis lpxL1 mutant induces less pro-inflammatory cytokines than the wild type, and IL-10 reduces the MyD88-dependent cytokines. |
therapeutic application
unassigned |
1
0 |
| 2.3.1.241 | Neoplasms |
11553534 |
Modification of lipid A biosynthesis in Neisseria meningitidis lpxL mutants: influence on lipopolysaccharide structure, toxicity, and adjuvant activity. |
diagnostic usage
therapeutic application
unassigned |
1
2
0 |
