EC Number |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
---|
1.3.1.118 | Tuberculosis |
7599116 |
Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis. |
therapeutic application unassigned |
1 0 |
1.3.1.118 | Tuberculosis |
7886450 |
Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. |
diagnostic usage therapeutic application unassigned |
1 1 0 |
1.3.1.118 | Tuberculosis |
8585728 |
Characterization of the katG and inhA genes of isoniazid-resistant clinical isolates of Mycobacterium tuberculosis. |
causal interaction therapeutic application unassigned |
1 1 0 |
1.3.1.118 | Tuberculosis |
8809032 |
Determination of the primary target for isoniazid in mycobacterial mycolic acid biosynthesis with Mycobacterium aurum A+. |
therapeutic application unassigned |
1 0 |
1.3.1.118 | Tuberculosis |
10336454 |
Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate. |
therapeutic application unassigned |
1 0 |
1.3.1.118 | Tuberculosis |
10708367 |
InhA, a target of the antituberculous drug isoniazid, is involved in a mycobacterial fatty acid elongation system, FAS-II. |
ongoing research unassigned |
1 0 |
1.3.1.118 | Tuberculosis |
12069966 |
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis. |
therapeutic application unassigned |
4 0 |
1.3.1.118 | Tuberculosis |
24527857 |
A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA. |
ongoing research therapeutic application unassigned |
2 2 0 |
1.3.1.118 | Tuberculosis |
26049421 |
Multidimensional infrared spectroscopy reveals the vibrational and solvation dynamics of isoniazid. |
causal interaction unassigned |
1 0 |
1.3.1.118 | Tuberculosis |
26147157 |
Rational Modulation of the Induced-Fit Conformational Change for Slow-Onset Inhibition in Mycobacterium tuberculosis InhA. |
causal interaction diagnostic usage unassigned |
1 3 0 |