EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    1.13.11.33 | Abortion, Spontaneous |
11549858 |
Reduced reproduction with increased abortion rate in transgenic mice that overexpress 15-lipoxygenase. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.13.11.33 | Adenocarcinoma |
10393855 |
15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
2
4
0 |
| 1.13.11.33 | Adenocarcinoma |
11014584 |
Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: correlation with grade and expression in high-grade prostatic intraepithelial neoplasia. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
4
3
1 |
| 1.13.11.33 | Adenocarcinoma |
11023533 |
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
4
4
1 |
| 1.13.11.33 | Adenocarcinoma |
15068670 |
15-lipoxygenase-1 expression upregulates and activates insulin-like growth factor-1 receptor in prostate cancer cells. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 1.13.11.33 | Adenocarcinoma |
15257547 |
15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 1.13.11.33 | Adenocarcinoma |
16820097 |
Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
4
4 |
| 1.13.11.33 | Adenocarcinoma, Bronchiolo-Alveolar |
15257547 |
15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation. |
causal interaction
diagnostic usage
ongoing research
unassigned |
4
3
4
0 |
| 1.13.11.33 | Adenoma |
16357157 |
The critical role of 15-lipoxygenase-1 in colorectal epithelial cell terminal differentiation and tumorigenesis. |
causal interaction
diagnostic usage
ongoing research
unassigned |
1
3
3
0 |
| 1.13.11.33 | Alzheimer Disease |
27484515 |
Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX. |
causal interaction
therapeutic application
unassigned |
2
3
0 |
