EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   3.4.24.85 | Alzheimer Disease |
12463168 |
Regulated intramembrane proteolysis: from the endoplasmic reticulum to the nucleus. |
causal interaction |
3 |
| 3.4.24.85 | Alzheimer Disease |
16697367 |
Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals. |
causal interaction |
4 |
| 3.4.24.85 | Alzheimer Disease |
18239854 |
Substrate specificity of gamma-secretase and other intramembrane proteases. |
causal interaction |
1 |
| 3.4.24.85 | Alzheimer Disease |
20021564 |
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. |
causal interaction |
4 |
| 3.4.24.85 | Alzheimer Disease |
20237298 |
Novel {gamma}-secretase inhibitors uncover a common nucleotide-binding site in JAK3, SIRT2, and PS1. |
causal interaction |
3 |
| 3.4.24.85 | Alzheimer Disease |
21106832 |
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the ?-secretase. |
causal interaction |
4 |
| 3.4.24.85 | Alzheimer Disease |
22238696 |
Presenilin is the molecular target of acidic ?-secretase modulators in living cells. |
causal interaction |
4 |
| 3.4.24.85 | Alzheimer Disease |
23359429 |
Highly efficient production of the Alzheimer's ?-Secretase integral membrane protease complex by a multi-gene stable integration approach. |
causal interaction |
1 |
| 3.4.24.85 | Alzheimer Disease |
26818522 |
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-? 42 Production. |
causal interaction |
4 |
| 3.4.24.85 | Alzheimer Disease |
27390881 |
Membrane trafficking and proteolytic activity of ?-secretase in Alzheimer's disease. |
causal interaction |
3 |
