EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
   3.3.2.6 | Acute Lung Injury |
28218840 |
Drug Repurposing of Histone Deacetylase Inhibitors That Alleviate Neutrophilic Inflammation in Acute Lung Injury and Idiopathic Pulmonary Fibrosis via Inhibiting Leukotriene A4 Hydrolase and Blocking LTB4 Biosynthesis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.3.2.6 | Asthma |
15715933 |
Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats. |
causal interaction
ongoing research
unassigned |
1
1
0 |
| 3.3.2.6 | Asthma |
19876785 |
Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. |
causal interaction
unassigned |
3
0 |
| 3.3.2.6 | Asthma |
23167751 |
Leukotriene B4 receptor locus gene characterisation and association studies in asthma. |
causal interaction
unassigned |
4
0 |
| 3.3.2.6 | Asthma |
30135247 |
An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 3.3.2.6 | Asthma |
32185106 |
Molecular docking and network connections of active compounds from the classical herbal formula Ding Chuan Tang. |
causal interaction
therapeutic application
unassigned |
2
1
0 |
| 3.3.2.6 | Atherosclerosis |
25721704 |
Variants in ALOX5, ALOX5AP and LTA4H are not associated with atherosclerotic plaque phenotypes: The Athero-Express Genomics Study. |
causal interaction
unassigned |
3
0 |
| 3.3.2.6 | Cardiovascular Diseases |
18323512 |
Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations. |
causal interaction
unassigned |
4
0 |
| 3.3.2.6 | Cardiovascular Diseases |
19876785 |
Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase. |
causal interaction
unassigned |
3
0 |
| 3.3.2.6 | Hidradenitis Suppurativa |
33592148 |
Discovery of LYS006, a Potent and Highly Selective Inhibitor of Leukotriene A4 Hydrolase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
