EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   2.7.12.2 | Neoplasm Metastasis |
21351092 |
"MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression" |
diagnostic usage
ongoing research
unassigned |
4
3
0 |
| 2.7.12.2 | Prostatic Neoplasms |
21351092 |
"MKK4 suppresses metastatic colonization by multiple highly metastatic prostate cancer cell lines through a transient impairment in cell cycle progression" |
diagnostic usage
ongoing research
unassigned |
4
3
0 |
| 2.7.12.2 | Neoplasm Metastasis |
25746833 |
(-)-Epigallocatechin-3-gallate inhibits osteosarcoma cell invasiveness by inhibiting the MEK/ERK signaling pathway in human osteosarcoma cells. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
3 |
| 2.7.12.2 | Osteosarcoma |
25746833 |
(-)-Epigallocatechin-3-gallate inhibits osteosarcoma cell invasiveness by inhibiting the MEK/ERK signaling pathway in human osteosarcoma cells. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
3 |
| 2.7.12.2 | Neoplasms |
23372439 |
(18)F-FLT-PET for Response Evaluation of MEK Inhibitor Selumetinib (AZD6244, ARRY-142886) in Patients with Solid Tumors. |
causal interaction
therapeutic application
unassigned |
2
2
0 |
| 2.7.12.2 | Melanoma |
18281615 |
17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
4
0 |
| 2.7.12.2 | Leukemia |
23041229 |
2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. |
unassigned |
0 |
| 2.7.12.2 | Skin Neoplasms |
33842463 |
3-Deoxysappanchalcone Inhibits Skin Cancer Proliferation by Regulating T-Lymphokine-Activated Killer Cell-Originated Protein Kinase in vitro and in vivo. |
unassigned |
0 |
| 2.7.12.2 | Neoplasm Metastasis |
27600294 |
3-Hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis by affecting EMT and repressing u-PA/MMP-2 via FAK-Src to MEK/ERK and RhoA/MLC2 pathways and reduces 143B tumor growth in vivo. |
ongoing research
unassigned |
3
0 |
| 2.7.12.2 | Neoplasms |
27600294 |
3-Hydroxyflavone inhibits human osteosarcoma U2OS and 143B cells metastasis by affecting EMT and repressing u-PA/MMP-2 via FAK-Src to MEK/ERK and RhoA/MLC2 pathways and reduces 143B tumor growth in vivo. |
ongoing research
unassigned |
3
0 |
