EC Number   |
Disease  |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   2.7.11.10 | Acquired Immunodeficiency Syndrome |
24917786 |
In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 2.7.11.10 | Acute Kidney Injury |
19546526 |
Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.7.11.10 | Acute Lung Injury |
12831615 |
[Potential molecular mechanism of multiple organ dysfunction syndrome induced by hemorrhage and endotoxin] |
causal interaction
unassigned |
4
0 |
| 2.7.11.10 | Adenocarcinoma |
11515677 |
Cytokine-activated degradation of inhibitory kappaB protein alpha is inhibited by the short-chain fatty acid butyrate. |
causal interaction
therapeutic application
unassigned |
3
2
0 |
| 2.7.11.10 | Adenocarcinoma |
12725325 |
Transfer of IkappaBalpha gene increase the sensitivity of paclitaxel mediated with caspase 3 activation in human lung cancer cell. |
ongoing research
therapeutic application
unassigned |
4
1
0 |
| 2.7.11.10 | Adenocarcinoma |
16353139 |
GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability. |
causal interaction
therapeutic application
unassigned |
3
3
0 |
| 2.7.11.10 | Adenocarcinoma |
19664134 |
Immunohistochemical analysis of NF-kappaB signaling proteins IKKepsilon, p50/p105, p52/p100 and RelA in prostate cancers. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
1 |
| 2.7.11.10 | Adenocarcinoma |
30105668 |
Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
3
0 |
| 2.7.11.10 | Adenocarcinoma of Lung |
19243472 |
Loss of IKKbeta activity increases p53 stability and p21 expression leading to cell cycle arrest and apoptosis. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 2.7.11.10 | Adenoma |
17132819 |
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
2
1
0 |
