EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   2.3.1.B41 | Lung Neoplasms |
33356727 |
?-Hederin inhibits the growth of lung cancer A549 cells in vitro and in vivo by decreasing SIRT6 dependent glycolysis. |
ongoing research
unassigned |
1
0 |
| 2.3.1.B41 | Neoplasms |
27152839 |
A Chemical Biology Approach to Reveal Sirt6-targeted Histone H3 Sites in Nucleosomes. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.B41 | Neoplasms |
30653310 |
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7. |
diagnostic usage
therapeutic application
unassigned |
3
1
0 |
| 2.3.1.B41 | Alzheimer Disease |
33920726 |
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
2
1
0 |
| 2.3.1.B41 | Neoplasms |
33920726 |
A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer's Disease, Aging, Cancer, Inflammation, and Diabetes. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
3
2
1
0 |
| 2.3.1.B41 | Carcinogenesis |
26898756 |
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. |
causal interaction
unassigned |
4
0 |
| 2.3.1.B41 | Neoplasms |
26898756 |
A crucial role of SUMOylation in modulating Sirt6 deacetylation of H3 at lysine 56 and its tumor suppressive activity. |
causal interaction
unassigned |
4
0 |
| 2.3.1.B41 | Hypoglycemia |
31967391 |
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice. |
causal interaction
therapeutic application
unassigned |
3
2
0 |
| 2.3.1.B41 | protein-long-chain fatty-acyl-lysine deacylase (nad+) deficiency |
31967391 |
A high-fat diet reverses metabolic disorders and premature aging by modulating insulin and IGF1 signaling in SIRT6 knockout mice. |
causal interaction
therapeutic application
unassigned |
3
2
0 |
| 2.3.1.B41 | Neoplasms |
23860128 |
A miR-34a-SIRT6 axis in the squamous cell differentiation network. |
causal interaction
diagnostic usage
unassigned |
3
3
0 |
