EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    1.3.98.1 | Autoimmune Diseases |
20310011 |
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
21861807 |
Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
24801997 |
Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. |
therapeutic application
unassigned |
3
0 |
| 1.3.98.1 | Autoimmune Diseases |
27721149 |
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
32353424 |
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
32696396 |
A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
4 |
| 1.3.98.1 | Autoimmune Diseases |
33291455 |
IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro. |
ongoing research
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Breast Neoplasms |
28196676 |
Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 1.3.98.1 | Breast Neoplasms |
28362817 |
Cis-eQTL-based trans-ethnic meta-analysis reveals novel genes associated with breast cancer risk. |
causal interaction
diagnostic usage
unassigned |
3
1
0 |
| 1.3.98.1 | Carcinogenesis |
29925003 |
Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation. |
unassigned |
0 |
