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EC Number
Disease
PubMed ID
Title of Publication
Category
Confidence Level
5'-nucleotidase deficiency
Clinical consequences of enzyme deficiencies in the erythrocyte.
causal interaction
therapeutic application
unassigned
3
2
0
5'-nucleotidase deficiency
Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.
causal interaction
unassigned
4
0
5'-nucleotidase deficiency
Inborn errors of purine metabolism: clinical update and therapies.
causal interaction
therapeutic application
unassigned
1
1
0
Abortion, Habitual
Interaction between adenosine deaminase and ABO system polymorphisms: effects on intrauterine survival and reproduction.
diagnostic usage
therapeutic application
unassigned
1
2
0
Abortion, Missed
Adenosine deaminase activity in serum and placenta of patients with anembryonic pregnancies and missed abortions.
diagnostic usage
ongoing research
unassigned
4
3
0
Abortion, Missed
Biochemical clinical factors associated with missed abortion independent of maternal age: A retrospective study of 795 cases with missed abortion and 694 cases with normal pregnancy.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
4
1
1
Abortion, Spontaneous
Adenosine deaminase and human reproduction: a comparative study of fertile women and women with recurrent spontaneous abortion.
diagnostic usage
ongoing research
unassigned
3
4
0
Abortion, Spontaneous
Adenosine deaminase activity and its isoenzyme pattern in women with recurrent spontaneous abortions.
causal interaction
unassigned
2
0
Abortion, Spontaneous
Repeated spontaneous abortion. Cooperative effects of ADA and ACP1 genetic polymorphisms.
diagnostic usage
ongoing research
unassigned
3
4
0
Abortion, Spontaneous
The ADA*2 allele of the adenosine deaminase gene (20q13.11) and recurrent spontaneous abortions: an age-dependent association.
diagnostic usage
ongoing research
therapeutic application
unassigned
2
3
3
0
Abortion, Spontaneous
Effect of ADA1 mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA.
diagnostic usage
ongoing research
unassigned
1
2
0
Abscess
Primary tuberculous abscess of the spleen in an immununocompetent patient diagnosed by biochemical markers and radiologic findings.
diagnostic usage
unassigned
1
0
Acidosis, Lactic
Pearson bone marrow-pancreas syndrome with insulin-dependent diabetes, progressive renal tubulopathy, organic aciduria and elevated fetal haemoglobin caused by deletion and duplication of mitochondrial DNA.
diagnostic usage
ongoing research
unassigned
1
2
0
Acne Vulgaris
The activity of adenosine deaminase and oxidative stress biomarkers in scraping samples of acne lesions.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Acne Vulgaris
Autoinflammatory diseases in childhood, part 1: monogenic syndromes.
causal interaction
unassigned
3
0
Acquired Immunodeficiency Syndrome
Adenosine deaminase, acquired immunodeficiency syndrome (AIDS), and hepatitis B infection.
causal interaction
diagnostic usage
ongoing research
unassigned
2
4
1
0
Acquired Immunodeficiency Syndrome
In vitro modulation of purine enzyme metabolism and lymphocyte surface marker expression by thymosin fraction 5 in homosexual males.
ongoing research
unassigned
3
0
Acquired Immunodeficiency Syndrome
Elevated erythrocyte adenosine deaminase activity in patients with acquired immunodeficiency syndrome.
causal interaction
diagnostic usage
unassigned
3
4
0
Acquired Immunodeficiency Syndrome
Adenosine deaminase in the acquired immunodeficiency syndrome.
causal interaction
diagnostic usage
unassigned
2
3
0
Acquired Immunodeficiency Syndrome
Adenosine deaminase activity and acquired immunodeficiency syndrome (AIDS).
diagnostic usage
unassigned
3
0
Acquired Immunodeficiency Syndrome
Elevated adenosine deaminase and purine nucleoside phosphorylase activity in peripheral blood null lymphocytes from patients with acquired immune deficiency syndrome.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
3
1
1
Acquired Immunodeficiency Syndrome
Prognostic value of adenosine deaminase compared to other markers for progression to acquired immunodeficiency syndrome among intravenous drug users.
diagnostic usage
unassigned
4
0
Acquired Immunodeficiency Syndrome
[Adenosine deaminase in the cerebrospinal fluid of patients with acquired immunodeficiency syndrome]
causal interaction
diagnostic usage
unassigned
2
3
0
Acquired Immunodeficiency Syndrome
Retrovirally transduced CD34++ human cord blood cells generate T cells expressing high levels of the retroviral encoded green fluorescent protein marker in vitro.
causal interaction
therapeutic application
unassigned
1
2
0
Acute Coronary Syndrome
Impact of the rs73598374 polymorphism of the adenosine deaminase gene on platelet reactivity and long-term outcomes among patients with acute coronary syndrome treated with ticagrelor.
causal interaction
ongoing research
unassigned
1
2
0
adenine phosphoribosyltransferase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
causal interaction
unassigned
4
0
adenine phosphoribosyltransferase deficiency
Use of intact erythrocytes in the diagnosis of inherited purine and pyrimidine disorders.
unassigned
0
Adenocarcinoma
Adenosine deaminase activity in peripheral lymphocytes of patients with gynaecologic malignancies.
causal interaction
diagnostic usage
therapeutic application
unassigned
1
3
1
0
Adenocarcinoma
Quantitative changes in adenosine deaminase isoenzymes in human colorectal adenocarcinomas.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
3
3
1
Adenocarcinoma
Adenosine deaminase (ADA; E.C. no. 3.5.4.4.) in colorectal adenocarcinoma in man.
causal interaction
therapeutic application
unassigned
2
1
0
Adenocarcinoma
Adenosine modulates cell proliferation in human colonic adenocarcinoma. I. Possible involvement of adenosine A1 receptor subtypes in HT29 cells.
unassigned
0
Adenocarcinoma
[Lactate dehydrogenase, adenosine deaminase and thymidine phosphorylase activity of blood and tissues in breast tumor patients]
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Adenocarcinoma
Increased Cytokeratin 19 Fragment Levels Are Positively Correlated with Adenosine Deaminase Activity in Malignant Pleural Effusions from Adenocarcinomas.
causal interaction
diagnostic usage
unassigned
3
3
0
Adenocarcinoma of Lung
Normal Tumor Markers and Increased Adenosine Deaminase in Pericardial Effusion Misdiagnosed as Tuberculous Pericarditis Ultimately Proven as Lung Adenocarcinoma with Pericardial Metastasis: a Case Report and Literature Review.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
3
1
0
Adenofibroma
[Lactate dehydrogenase, adenosine deaminase and thymidine phosphorylase activity of blood and tissues in breast tumor patients]
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
adenosine deaminase deficiency
Characterization of the residual adenosine deaminating activity in the spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
2
1
0
adenosine deaminase deficiency
Bone marrow transplantation in a case of severe combined immunodeficiency with adenosine deaminase deficiency [proceedings]
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Two-dimensional thin-layer chromatography for the screening of disorders of purine and pyrimidine metabolism.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Absence of oroticaciduria in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency.
causal interaction
diagnostic usage
ongoing research
unassigned
3
1
1
0
adenosine deaminase deficiency
[Immunological failure caused by adenosine deaminase deficiency]
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Purine dysfunction in cells from patients with adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
Adenosine inhibition of lymphocyte-mediated cytolysis: possible role of cyclic adenosine monophosphate.
causal interaction
ongoing research
unassigned
2
2
0
adenosine deaminase deficiency
Adenosine deaminase deficiency and severe combined immunodeficiency disease.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).
causal interaction
unassigned
3
0
adenosine deaminase deficiency
In vitro platelet abnormality in adenosine deaminase deficiency and severe combined immunodeficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Enzyme replacement and other biochemical approaches to the therapy of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
2
0
adenosine deaminase deficiency
Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
2
0
adenosine deaminase deficiency
Studies of the relationship between adenosine deaminase and immune function.
diagnostic usage
ongoing research
unassigned
1
2
0
adenosine deaminase deficiency
Overproduction of adenine deoxynucleosides and deoxynucletides in adenosine deaminase deficiency with severe combined immunodeficiency disease.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Limited effect of erythrocyte and plasma infusions in adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
In vivo and in vitro effects of thymosin and adenosine deaminase on adenosine-deaminase-deficient lymphocytes.
ongoing research
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Purine excretion by mouse peritoneal macrophages lacking adenosine deaminase activity.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Deoxyadenosine inhibits DNA synthesis in cultured human fibroblasts.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: disappearance of adenine deoxynucleotides from a patient's erythrocytes after successful marrow transplantation.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
Purine metabolism in adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Clinical delineation of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Screening for primary immunodeficiencies associated with purine nucleoside phosphorylase deficiency or adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
2
0
adenosine deaminase deficiency
A micromethod for determining adenosine deaminase and purine nucleoside phosphorylase activity in cells from human peripheral blood.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
The role of de novo purine synthesis in lymphocyte transformation.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: frequency and comparative pathology in autosomally recessive severe combined immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Erythrocyte adenosine deaminase deficiency without immunodeficiency. Evidence for an unstable mutant enzyme.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Effect of adenosine deaminase replacement therapy on a child of adenosine deaminase deficiency with severe combined immunodeficiency disease.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Severe combined immunodeficiency disease with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
1
0
adenosine deaminase deficiency
A family of adenosine deaminase deficiency with severe combined immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine as a prostaglandin antagonist. Possible mechanism of the defect in combined immunodeficiency disease due to adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Adenosine deaminase activity in normal tissues and tissues from a child with severe combined immunodeficiency and adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
2
2
0
adenosine deaminase deficiency
Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Evaluation of the expanded newborn screening program in New York City.
causal interaction
diagnostic usage
unassigned
2
1
0
adenosine deaminase deficiency
Abnormal platelet aggregation in severe combined immunodeficiency disease with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
1
0
adenosine deaminase deficiency
An improved screening test for adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
3
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Urinary excretion of purines, purine nucleosides, and pseudouridine in adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency and immunodeficiencies.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: another family with "silent" ADA allele and normal ADA activity in two heterozygotes.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Purine excretion by cultured skin fibroblasts from patients with abnormal purine metabolism.
ongoing research
unassigned
4
0
adenosine deaminase deficiency
Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
The chondro-osseous dysplasia of adenosine deaminase deficiency with severe combined immunodeficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
2
4
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency in primary immunodeficiencies (author's transl)]
causal interaction
diagnostic usage
unassigned
3
2
0
adenosine deaminase deficiency
Characterization of residual enzyme activity in fibroblasts from patients with adenosine deaminase deficiency and combined immunodeficiency: evidence for a mutant enzyme.
causal interaction
diagnostic usage
ongoing research
unassigned
4
1
4
0
adenosine deaminase deficiency
Purine metabolism in adenosine deaminase deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Combined immunodeficiency disease associated with adenosine deaminase deficiency. Report on a workshop held in Albany, New York, October 1, 1973.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Severe combined immunodeficiency and adenosine deaminase deficiency.
causal interaction
diagnostic usage
ongoing research
therapeutic application
4
4
4
2
adenosine deaminase deficiency
[Molecular pathology of immunological deficiency. Apropos of adenosine deaminase deficiency and nucleoside phosphorylase deficiency]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency in combined immunologic deficiency disease.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Heterogeneity for adenosine deaminase deficiency: Expression of the enzyme in cultured skin fibroblasts and amniotic fluid cells.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
Inhibition of mitogen mediated lymphocyte blastogenesis by adenosine.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Hereditary sever combined immunodeficiency and adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
[Gene transfer and gene therapy]
causal interaction
ongoing research
therapeutic application
unassigned
2
4
2
0
adenosine deaminase deficiency
Gene therapy techniques.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Antibody responses to bacteriophage phi X174 in patients with adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Deoxyadenosine toxicity in an adenosine deaminase-inhibited human CCRF-CEM T-lymphoblastoid cell line causes cell swelling.
diagnostic usage
ongoing research
therapeutic application
unassigned
2
4
1
0
adenosine deaminase deficiency
Insulin-dependent diabetes mellitus and severe atopic dermatitis in a child with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
2
0
adenosine deaminase deficiency
[Treatment of adenosine deaminase deficiency with adenosine deaminase combined with polyethylene glycol]
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
Long-term expression of human adenosine deaminase in rhesus monkeys transplanted with retrovirus-infected bone-marrow cells.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: a model system for human somatic cell gene correction therapy.
causal interaction
ongoing research
therapeutic application
unassigned
1
4
4
0
adenosine deaminase deficiency
IgG antibody response to polyethylene glycol-modified adenosine deaminase in patients with adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
2
2
0
adenosine deaminase deficiency
Homozygosity for a newly identified missense mutation in a patient with very severe combined immunodeficiency due to adenosine deaminase deficiency (ADA-SCID).
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Purine nucleoside modulation of functions of human lymphocytes.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Chondroosseous dysplasia in severe combined immunodeficiency due to adenosine deaminase deficiency (chondroosseous dysplasia in ADA deficiency SCID).
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Severe combined immunodeficiency disease, adenosine deaminase deficiency and gene therapy.
causal interaction
ongoing research
therapeutic application
unassigned
4
2
4
0
adenosine deaminase deficiency
Basis for the chondro-osseous dysplasia associated with adenosine deaminase deficiency: selective toxicity to immature chondrocytes.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene therapy in man and mice: adenosine deaminase deficiency, ornithine transcarbamylase deficiency, and Duchenne muscular dystrophy.
causal interaction
ongoing research
therapeutic application
unassigned
3
3
4
0
adenosine deaminase deficiency
Effects of deoxyadenosine on ribonucleotide reductase in adenosine deaminase-deficient lymphocytes.
diagnostic usage
ongoing research
unassigned
1
3
0
adenosine deaminase deficiency
Successful bone marrow transplantation and treatment of BCG infection in two patients with severe combined immunodeficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency due to heterozygous abnormality consisting of a deletion of exon 7 and the absence of enzyme mRNA.
causal interaction
diagnostic usage
ongoing research
unassigned
2
2
3
0
adenosine deaminase deficiency
[Polyethylene glycol-adenosine deaminase: a new adenosine deaminase deficiency therapy. Value of deoxyadenosine triphosphate determination for therapeutic monitoring]
causal interaction
diagnostic usage
therapeutic application
unassigned
2
1
4
0
adenosine deaminase deficiency
Paradoxical expression of adenosine deaminase in T cells cultured from a patient with adenosine deaminase deficiency and combine immunodeficiency.
diagnostic usage
ongoing research
unassigned
1
3
0
adenosine deaminase deficiency
Evidence that X-linked severe combined immunodeficiency is not a differentiation defect of T lymphocytes.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Short stature/short limb skeletal dysplasia with severe combined immunodeficiency and bowing of the femora: report of two patients and review.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Lymphocytes as cellular vehicles for gene therapy in mouse and man.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
A case of osteoporosis associated with adenosine deaminase deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Immunodeficiency secondary to adenosine deaminase deficiency and purine nucleoside phosphorylation deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Effect of red cell transfusions on clinical, immunological and biochemical parameters of a child with adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
Influence of adenosine deaminase inhibition on the phosphoinositide turnover in the initial stages of human T cell activation.
ongoing research
unassigned
4
0
adenosine deaminase deficiency
Hot spot mutations in adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Inosine triphosphate pyrophosphohydrolase deficiency in a kindred with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
1
0
adenosine deaminase deficiency
Comparison of red cell transfusion and polyethylene glycol-modified adenosine deaminase therapy in an adenosine deaminase-deficient child: measurement of erythrocyte deoxyadenosine triphosphate as a useful tool.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Substrate inhibition of adenosine phosphorylation in adenosine deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine phosphoribosyltransferase deficient erythrocytes.
causal interaction
ongoing research
unassigned
1
4
0
adenosine deaminase deficiency
Lymphokine-activated killer cells in primary immunodeficiencies and acquired immunodeficiency syndrome.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Interleukin 2 responsive lymphocytes in patients with adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
1
0
adenosine deaminase deficiency
HLA-haploidentical bone marrow transplantation in three infants with adenosine deaminase deficiency: stable immunological reconstitution and reversal of skeletal abnormalities.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
2
2
0
adenosine deaminase deficiency
1-Methyladenine in urine of an adenosine deaminase-deficient adult without immunodeficiency.
unassigned
0
adenosine deaminase deficiency
Comparative characterization of B-lymphoblastoid cell lines in adenosine deaminase deficiency and its heterozygote.
causal interaction
ongoing research
unassigned
1
4
0
adenosine deaminase deficiency
Immunological and metabolic reconstitution following successful bone marrow transplantation from a HLA-identical sibling in an infant with adenosine deaminase deficiency and severe combined immunodeficiency: partial restoration of purine metabolism.
causal interaction
therapeutic application
unassigned
1
1
0
adenosine deaminase deficiency
Somatic cell gene therapy: the model of adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
4
3
0
adenosine deaminase deficiency
Ecto-enzyme activity of human erythrocyte adenosine deaminase.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency.
ongoing research
unassigned
3
0
adenosine deaminase deficiency
Rejection of bone marrow transplant and resistance of alloantigen reactive cells to in vivo deoxyadenosine in adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Nucleoside kinases in T and B lymphoblasts distinguished by autoradiography.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
First trimester diagnosis of adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
1
0
adenosine deaminase deficiency
Deoxycytidine therapy in two patients with adenosine deaminase deficiency and severe immunodeficiency disease.
causal interaction
therapeutic application
unassigned
4
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase.
causal interaction
therapeutic application
unassigned
1
3
0
adenosine deaminase deficiency
Reconstitution of T- and B-cell function after T-lymphocyte-depleted haploidentical bone marrow transplantation in severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
[Transplantation of T cell-depleted marrow from parents in a case of severe combined immunodeficiency with adenosine deaminase deficiency]
causal interaction
unassigned
2
0
adenosine deaminase deficiency
Heterogeneity of biochemical, clinical and immunological parameters in severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Towards gene therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency and chondro-osseous dysplasia.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.
diagnostic usage
ongoing research
unassigned
1
4
0
adenosine deaminase deficiency
Probable autoimmune thyroid disease and combined immunodeficiency disease.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Lymphoma in a patient with severe combined immunodeficiency with adenosine deaminase deficiency, following unsustained engraftment of histoincompatible T cell-depleted bone marrow.
causal interaction
diagnostic usage
unassigned
1
2
0
adenosine deaminase deficiency
Identification of a deletion in the adenosine deaminase gene in a child with severe combined immunodeficiency.
causal interaction
therapeutic application
unassigned
4
2
0
adenosine deaminase deficiency
Polymorphism of S-adenosylhomocysteine hydrolase in Italy.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Lack of adenosine deaminase deficiency in the mutant mouse wasted.
causal interaction
ongoing research
unassigned
1
1
0
adenosine deaminase deficiency
Partial adenosine deaminase deficiency: another family from southern Africa.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Abnormalities in S-adenosylhomocysteine hydrolysis, ATP catabolism, and lymphoid differentiation in adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Genetic expression in partial adenosine deaminase deficiency. mRNA levels and protein turnover for the enzyme variants in human B-lymphoblast cell lines.
causal interaction
diagnostic usage
ongoing research
unassigned
3
1
2
0
adenosine deaminase deficiency
Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency.
ongoing research
unassigned
4
0
adenosine deaminase deficiency
Morphological changes in leukemic lymphoblasts and normal lymphocytes treated with deoxyadenosine plus deoxycoformycin.
causal interaction
therapeutic application
unassigned
1
4
0
adenosine deaminase deficiency
The effects of an induced adenosine deaminase deficiency on T-cell differentiation in the rat.
causal interaction
ongoing research
unassigned
4
4
0
adenosine deaminase deficiency
Interleukin 2 liberation and absorption capacities of rat T lymphocytes in conditions of severe adenylic nucleotide pool depletion due to adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
2
1
0
adenosine deaminase deficiency
Metabolic basis for immune dysfunction in adenosine deaminase deficiency.
unassigned
0
adenosine deaminase deficiency
Liquid-chromatographic measurement of purine nucleotides in blood cells.
ongoing research
unassigned
2
0
adenosine deaminase deficiency
Complete and partial adenosine deaminase deficiency. Relationship of immune function to metabolite concentrations, enzyme activity, and effects of therapy.
causal interaction
ongoing research
therapeutic application
unassigned
1
2
1
0
adenosine deaminase deficiency
Purine metabolic enzymes in lymphocytes. IV. Effects of enzyme inhibitors and enzyme substrates on the blastogenic responses of human lymphocytes.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
An abnormal amino acid pattern in adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Lymphocyte dysfunction after DNA damage by toxic oxygen species. A model of immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Early prenatal investigation of a pregnancy at risk of adenosine deaminase deficiency using chorionic villi.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
1
2
1
adenosine deaminase deficiency
Iron overload as a result of transfusion therapy in a patient with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Errors of morphogenesis and inborn errors of immunity 20 years after the discovery of DiGeorge anomaly.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
Altered regulation of S-adenosylmethionine dependent methylation in adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Red-blood-cell adenosine deaminase deficiency in a "healthy" Kung individual.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
Adenosine deaminase deficiency in a child with severe combined immunodeficiency.
causal interaction
therapeutic application
unassigned
4
1
0
adenosine deaminase deficiency
Workshop on severe combined immunological deficiency disease and adenosine deaminase deficiency. Albany, New York, on October 1, 1973.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: the first inborn error of metabolism noted in immunodeficiency disease.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Detection of the carrier state in combined immunodeficiency disease associated with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
4
0
adenosine deaminase deficiency
Adenosine deaminase messenger RNAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
Amerioration of neurologic abnormalities after "enzyme replacement" in adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Lithium chloride induces partial responsiveness to LPS in nonresponder B cells.
unassigned
0
adenosine deaminase deficiency
Adenosine deaminase deficiency without immunodeficiency: clinical and metabolic studies.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency and severe combined immunodeficiency disease.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Metabolic abnormalities of human adenosine deaminase deficiency reproduced in the mouse by 2'-deoxycoformycin, and adenosine deaminase inhibitor.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Adenosine deaminase activity and superoxide formation during phagocytosis and membrane perturbation of macrophages.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Effects of deoxyadenosine on the activation of ADA inhibited T & B cells.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Positive correlation between adenosine deaminase activity and superoxide formation during phagocytosis.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
5'-Deoxy-5'-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase: correlation with inhibition of Con A induced proliferation.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Adenosine deaminase is not required for the generation of superoxide anion.
causal interaction
ongoing research
therapeutic application
unassigned
3
1
2
0
adenosine deaminase deficiency
Treatment of respiratory viral infection in an immunodeficient infant with ribavirin aerosol.
causal interaction
diagnostic usage
ongoing research
unassigned
2
1
1
0
adenosine deaminase deficiency
Evidence for distinct catabolic pathways of adenine ribonucleotides and deoxyribonucleotides in human T lymphoblastoid cells.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
dATP accumulation and ATP depletion in platelets in adenosine deaminase deficiency: significance for the immune response?
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Characterization of a cultured human T-cell line with genetically altered ribonucleotide reductase activity. Model for immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Lymphocyte subpopulations in primary immunodeficiency disorders.
causal interaction
diagnostic usage
unassigned
3
3
0
adenosine deaminase deficiency
HLA typing of amniotic fluid cells for the prenatal determination of therapeutic transplantation options for a fetus affected with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
[A method detecting heterozygotes for adenosine deaminase deficiency with blood samples dried on filter paper]
ongoing research
unassigned
2
0
adenosine deaminase deficiency
Adenosine deaminase deficiency with normal immune function. An acidic enzyme mutation.
causal interaction
ongoing research
therapeutic application
unassigned
3
3
1
0
adenosine deaminase deficiency
Intravenous deoxycytidine therapy in a patient with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
3
0
adenosine deaminase deficiency
Prenatal diagnosis of three cases of severe combined immunodeficiency: severe T cell deficiency during the first half of gestation in fetuses with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Dipyridamole and intravenous deoxycytidine therapy in a patient with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Metabolic findings in a patient with adenosine deaminase deficiency and severe combined immunodeficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Immunodeficiency disease in animals.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Testing newborns for adenosine deaminase deficiency not cost effective.
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
S-Adenosylhomocysteine hydrolase activity in a lymphoblastoid cell line from a patient with adenosine deaminase dificiency disease.
ongoing research
unassigned
2
0
adenosine deaminase deficiency
Rapid prenatal diagnosis of adenosine deaminase deficiency and other purine disorders using foetal blood.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
A phenotypically normal revertant of an adenosine deaminase-deficient lymphoblast cell line.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Genetic heterogeneity in partial adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Animal model for immune dysfunction associated with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Role of adenosine deaminase in the early stages of precursor T cell maturation.
diagnostic usage
unassigned
3
0
adenosine deaminase deficiency
Inability of immunocompetent thymocytes to produce T-cell growth factor under adenosine deaminase deficiency conditions.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Consequences of adenosine deaminase deficiency on thymocyte metabolism.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
Purine deoxynucleoside toxicity in nondividing human lymphoid cells.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Immunoreactive protein in adenosine deaminase deficient human lymphoblast cell lines.
diagnostic usage
ongoing research
unassigned
1
4
0
adenosine deaminase deficiency
Deoxycoformycin-induced response in chronic lymphocytic leukaemia: deoxyadenosine toxicity in non-replicating lymphocytes.
diagnostic usage
ongoing research
unassigned
1
2
0
adenosine deaminase deficiency
Deoxyadenosine triphosphate accumulation in erythrocytes of deoxycoformycin-treated mice.
ongoing research
unassigned
4
0
adenosine deaminase deficiency
Formation and degradation of deoxyadenosine nucleotides in inherited adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
S-Adenosylhomocysteine accumulation and selective cytotoxicity in cultured T- and B-lymphocytes.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Increased excretion of modified adenine nucleosides by children with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Effect of red cell transfusions, thymic hormone and deoxycytidine in severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
[Treatment of severe combined immunodeficiency with bone marrow or foetal liver transplants (author's transl)]
causal interaction
diagnostic usage
unassigned
1
1
0
adenosine deaminase deficiency
Adenosine and deoxyadenosine metabolism in the erythrocytes of a patient with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
The human genes for S-adenosylhomocysteine hydrolase and adenosine deaminase are syntenic on chromosome 20.
unassigned
0
adenosine deaminase deficiency
Deoxycytidine excretion by mouse peritoneal macrophages: its implication in modulation of immunological functions.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
[Severe combined immunodeficiency with adenosine deaminase deficiency (author's transl)]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Hereditary adenosine deaminase deficiency detected by screening test.
causal interaction
diagnostic usage
unassigned
3
2
0
adenosine deaminase deficiency
Basic defect in the expression of adenosine deaminase in ADA- SCID disease investigated through the cells of an obligate heterozygote.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Prenatal diagnosis for adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
4
2
0
adenosine deaminase deficiency
A new approach to detection of heterozygotes for adenosine deaminase deficiency: a hypothetical method.
causal interaction
diagnostic usage
therapeutic application
unassigned
2
2
3
0
adenosine deaminase deficiency
Primary hyperoxaluria and adenosine deaminase deficiency without immunodeficiency.
causal interaction
diagnostic usage
unassigned
1
1
0
adenosine deaminase deficiency
Partial resolution of bone lesions. A child with severe combined immunodeficiency disease and adenosine deaminase deficiency after enzyme-replacement therapy.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
adenosine deaminase deficiency
Prenatal detection of a probable heterozygote for ADA deficiency and severe combined immunodeficiency disease using a microradioassay.
diagnostic usage
unassigned
2
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency and severe combined immunodeficiency]
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Decreased S-adenosylhomocysteine hydrolase in inborn errors of purine metabolism.
causal interaction
ongoing research
unassigned
4
3
0
adenosine deaminase deficiency
Acquired hemoglobin H disease associated with idiopathic myelofibrosis and hereditary adenosine deaminase deficiency.
unassigned
0
adenosine deaminase deficiency
Severe combined immunodeficiency and adenosine deaminase deficiency: failure of enzyme replacement therapy.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
2
4
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: molecular basis and recent developments.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
PEG-ADA replacement therapy for adenosine deaminase deficiency: an update after 8.5 years.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Genetic manipulation of hematopoietic stem cells in adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
1
0
adenosine deaminase deficiency
p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with CD34+ selected autologous peripheral blood cells transduced with a human ADA gene. Amendment to clinical research project, Project 90-C-195, January 10, 1992.
causal interaction
ongoing research
therapeutic application
unassigned
3
2
2
0
adenosine deaminase deficiency
Gene therapy: here to stay.
ongoing research
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
PEG-ADA: an alternative to haploidentical bone marrow transplantation and an adjunct to gene therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene therapy for adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
4
4
4
0
adenosine deaminase deficiency
Cellular gene therapy: an overview.
causal interaction
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
[Gene therapy: application possibilities]
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene therapy for cystic fibrosis.
causal interaction
therapeutic application
unassigned
1
3
0
adenosine deaminase deficiency
[Principles, possibilities and limits of gene therapy]
causal interaction
diagnostic usage
therapeutic application
unassigned
3
3
1
0
adenosine deaminase deficiency
Gene therapy for inherited disorders.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Bone marrow gene therapy for adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency with altered biochemical parameters in two sisters with late-onset immunodeficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Long-term culture and T cell receptor analysis of T cell clones isolated from a patient with adenosine deaminase deficiency and type I diabetes.
diagnostic usage
ongoing research
unassigned
3
4
0
adenosine deaminase deficiency
[Present status and future prospects of human gene therapy]
causal interaction
ongoing research
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
2-Chlorodeoxyadenosine: hairy cell leukemia takes a surprising turn.
causal interaction
diagnostic usage
unassigned
2
1
0
adenosine deaminase deficiency
[Present status and future prospects of human gene therapy]
causal interaction
ongoing research
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
Molecular basis of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Purine metabolism of lymphocytes. Targets for chemotherapy drug development.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Adult onset immunodeficiency caused by inherited adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adult presentation of adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
1
0
adenosine deaminase deficiency
2-Chlorodeoxyadenosine in haematological malignancies.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Heterogeneity of phenotype in two siblings with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
3
0
adenosine deaminase deficiency
Enzyme replacement therapy of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase (PEG-ADA).
causal interaction
therapeutic application
unassigned
2
2
0
adenosine deaminase deficiency
Correct splicing despite mutation of the invariant first nucleotide of a 5' splice site: a possible basis for disparate clinical phenotypes in siblings with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Management options: SCIDS with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
The molecular genetics of pediatric lipid disorders: recent progress and future research directions.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
adenosine deaminase deficiency
[Treatment of adenosine deaminase deficiency using gene transfer]
causal interaction
ongoing research
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Severe combined immunodeficiency: a retrospective single-center study of clinical presentation and outcome in 117 patients.
causal interaction
diagnostic usage
unassigned
2
4
0
adenosine deaminase deficiency
Overview of biochemical abnormalities and molecular genetics of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
2
0
adenosine deaminase deficiency
Enzyme replacement therapy with polyethylene glycol-adenosine deaminase in adenosine deaminase deficiency: overview and case reports of three patients, including two now receiving gene therapy.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Development of gene therapy for immunodeficiency: adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Are contemporary methods for somatic gene therapy suitable for clinical applications?
ongoing research
therapeutic application
unassigned
3
2
0
adenosine deaminase deficiency
[Severe combined immunodeficiency: description of a clinical case]
causal interaction
diagnostic usage
ongoing research
unassigned
1
1
2
0
adenosine deaminase deficiency
Steps toward gene therapy: 1. The initial trials.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
Deoxyadenosine blockade of G0 to G1 transition in lymphocytes: possible involvement of protein kinases.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Brief report: hepatic dysfunction as a complication of adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Current status and future prospects of human gene therapy.
ongoing research
therapeutic application
unassigned
1
1
0
adenosine deaminase deficiency
[Gene therapy for adenosine deaminase deficiency]
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Molecular analysis of T lymphocyte-directed gene therapy for adenosine deaminase deficiency: long-term expression in vivo of genes introduced with a retroviral vector.
causal interaction
ongoing research
therapeutic application
unassigned
2
1
1
0
adenosine deaminase deficiency
[Clinical study of gene therapy for adenosine deaminase deficiency]
causal interaction
ongoing research
therapeutic application
unassigned
3
4
4
0
adenosine deaminase deficiency
Bone marrow gene transfer in three patients with adenosine deaminase deficiency.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
1
2
4
adenosine deaminase deficiency
Sensorineural deafness in siblings with adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
2
0
adenosine deaminase deficiency
Human gene therapy in gastrointestinal diseases: in vivo and in vitro approaches.
diagnostic usage
unassigned
4
0
adenosine deaminase deficiency
Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).
ongoing research
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency in adults.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
1
1
0
adenosine deaminase deficiency
Cellular radiosensitivity in human severe-combined-immunodeficiency (SCID) syndromes.
diagnostic usage
ongoing research
unassigned
2
3
0
adenosine deaminase deficiency
Keratinocyte gene therapy for adenosine deaminase deficiency: a model approach for inherited metabolic disorders.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
SCID: the role of adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Detection of JC virus by anti-VP1 immunohistochemistry in brains with progressive multifocal leukoencephalopathy.
causal interaction
diagnostic usage
ongoing research
unassigned
3
3
3
0
adenosine deaminase deficiency
Memory of extracellular adenosine A2A purinergic receptor-mediated signaling in murine T cells.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
A girl with diabetes and severe combined immunodeficiency from adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
3
0
adenosine deaminase deficiency
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Food allergy in a patient with adenosine deaminase deficiency undergoing enzyme replacement with polyethylene glycol-modified adenosine deaminase.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
New models for the study of adenosine deaminase deficiency.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
1
2
4
adenosine deaminase deficiency
Insights into adenosine deaminase deficiency provided by murine fetal thymic organ culture with 2'-deoxycoformycin.
causal interaction
ongoing research
unassigned
2
2
0
adenosine deaminase deficiency
Adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency in common variable immunodeficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Cost analysis of treatments for severe combined immunodeficiency patients caused by adenosine deaminase deficiency: comparison of gene therapy and bone marrow transplantation.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Glaxo/MRS Young Investigator Medal. Molecular studies on adenosine deaminase deficiency and hereditary haemorrhagic telangiectasia.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
4
1
1
adenosine deaminase deficiency
Gene therapy for ovarian carcinoma.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
dATP causes specific release of cytochrome C from mitochondria.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: genotype-phenotype correlations based on expressed activity of 29 mutant alleles.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: clinical expression, molecular basis, and therapy.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
1
4
0
adenosine deaminase deficiency
[Gene therapy: a review 6 years after the first trials in man. Round Table No 6 at Giens XIII]
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Towards gene therapy for the central nervous system.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
3
0
adenosine deaminase deficiency
Elevation of serum IgE level and peripheral eosinophil count during T lymphocyte-directed gene therapy for ADA deficiency: implication of Tc2-like cells after gene transduction procedure.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Nucleotide pool imbalance and adenosine deaminase deficiency induce alterations of N-region insertions during V(D)J recombination.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Engraftment and chimerism, particularly of T- and B-cells, in children undergoing allogeneic bone marrow transplantation.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Gene therapy for severe combined immunodeficiency caused by adenosine deaminase deficiency: improved retroviral vectors for clinical trials.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Production of IL-4 and expression of CD40 ligand by human CD8 T cells.
ongoing research
unassigned
2
0
adenosine deaminase deficiency
Recombinant proteins for genetic disease.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene therapy of genetic diseases and cancer.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Protection by various deoxynucleosides against deoxyadenosine-induced DNA damage in adenosine deaminase-inactivated lymphocytes.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
2
3
0
adenosine deaminase deficiency
In vitro and in vivo studies with human carrier erythrocytes loaded with polyethylene glycol-conjugated and native adenosine deaminase.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
adenosine deaminase deficiency
Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities.
causal interaction
diagnostic usage
ongoing research
unassigned
3
1
3
0
adenosine deaminase deficiency
Nonmyeloablative stem cell transplantation for congenital immunodeficiencies.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Disseminated infection with varicella-zoster virus vaccine strain presenting as hepatitis in a child with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency as the first target disorder in gene therapy.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling.
causal interaction
therapeutic application
unassigned
3
2
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency]
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Carrier erythrocyte entrapped adenosine deaminase therapy in adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
2
3
0
adenosine deaminase deficiency
Inhibition of fetal thymic caspases abrogates the consequences of adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency with mosaicism for a "second-site suppressor" of a splicing mutation: decline in revertant T lymphocytes during enzyme replacement therapy.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Recalcitrant palmoplantar warts associated with adult-onset adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene therapy in infants with severe combined immunodeficiency.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
Atmospheric pressure ionization mass spectrometry of purine and pyrimidine markers of inherited metabolic disorders.
causal interaction
diagnostic usage
ongoing research
unassigned
2
1
3
0
adenosine deaminase deficiency
Polyethylene glycol-conjugated adenosine phosphorylase: development of alternative enzyme therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Giant-cell fibroblastoma in a patient with a bone-marrow transplant.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene therapy for inherited immunodeficiencies.
ongoing research
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Genotype is an important determinant of phenotype in adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
1
0
adenosine deaminase deficiency
Management of Gaucher disease in a post-communist transitional health care system: Croatian experience.
causal interaction
ongoing research
therapeutic application
unassigned
3
3
3
0
adenosine deaminase deficiency
Capillary electrophoresis in diagnosis and monitoring of adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
1
4
0
adenosine deaminase deficiency
Impaired germinal center maturation in adenosine deaminase deficiency.
causal interaction
ongoing research
unassigned
3
1
0
adenosine deaminase deficiency
Gene therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Bilateral sensorineural deafness in adenosine deaminase-deficient severe combined immunodeficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Gene therapy for severe combined immune deficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Gene transfer and antisense nucleic acid techniques.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Perspectives of gene therapy for primary immunodeficiencies.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
2
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: metabolic basis of immune deficiency and pulmonary inflammation.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Activation of deoxycytidine kinase by deoxyadenosine: implications in deoxyadenosine-mediated cytotoxicity.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
[Treatment of primary immune defects]
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
[Gene therapy for adenosine deaminase deficiency]
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Hematopoietic stem cell gene therapy with drug resistance genes: an update.
causal interaction
therapeutic application
unassigned
4
2
0
adenosine deaminase deficiency
Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Disorders of purine and pyrimidine metabolism.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Drug evaluation: ADA-transduced hematopoietic stem cell therapy for ADA-SCID.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene therapy in cardiac arrhythmias.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
Management options for adenosine deaminase deficiency; proceedings of the EBMT satellite workshop (Hamburg, March 2006).
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Autoimmune thyroiditis and acquired hypothyroidism in an infant with severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Aminohydrolases acting on adenine, adenosine and their derivatives.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene therapy in The Netherlands: highlights from the Low Countries.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Neurologic abnormalities in patients with adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
4
1
0
adenosine deaminase deficiency
Generation of a high-titer packaging cell line for the production of retroviral vectors in suspension and serum-free media.
causal interaction
ongoing research
therapeutic application
unassigned
3
3
1
0
adenosine deaminase deficiency
Treatment of adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
3
4
0
adenosine deaminase deficiency
Potential of gene therapy in bone marrow transplantation.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Severe combined immunodeficiency: a national surveillance study.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency can present with features of Omenn syndrome.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Towards a rAAV-based gene therapy for ADA-SCID: from ADA deficiency to current and future treatment strategies.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
[Diagnosis and treatment of Gaucher disease in Croatia]
causal interaction
diagnostic usage
therapeutic application
unassigned
3
3
3
0
adenosine deaminase deficiency
[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]
causal interaction
therapeutic application
unassigned
3
2
0
adenosine deaminase deficiency
Gene therapy for immunodeficiency due to adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
4
3
4
0
adenosine deaminase deficiency
Progress in genetic therapy for severe combined immunodeficiency associated with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Polyethylene glycol-modified adenosine deaminase improved lung disease but not liver disease in partial adenosine deaminase deficiency.
unassigned
0
adenosine deaminase deficiency
Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID).
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Progress and prospects: gene therapy for inherited immunodeficiencies.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
A novel mutation in the ADA gene causing severe combined immunodeficiency in an Arab patient: a case report.
causal interaction
diagnostic usage
unassigned
3
4
0
adenosine deaminase deficiency
Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning.
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Late-onset adenosine deaminase deficiency presenting with Heck's disease.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Role of reduced intensity conditioning in T-cell and B-cell immune reconstitution after HLA-identical bone marrow transplantation in ADA-SCID.
causal interaction
ongoing research
therapeutic application
unassigned
1
2
1
0
adenosine deaminase deficiency
Bone marrow transplantation and alternatives for adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
1
2
1
0
adenosine deaminase deficiency
Gene therapy for adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
4
1
4
0
adenosine deaminase deficiency
[Gene therapy for severe combined immunodeficiency]
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency.
diagnostic usage
ongoing research
unassigned
2
1
0
adenosine deaminase deficiency
Hyperbilirubinemia and Rapid Fatal Hepatic Failure in Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency (ADA-SCID).
causal interaction
diagnostic usage
unassigned
3
1
0
adenosine deaminase deficiency
Genotoxicity of retroviral hematopoietic stem cell gene therapy.
therapeutic application
unassigned
3
0
adenosine deaminase deficiency
Purine metabolism, immune reconstitution, and abdominal adipose tumor after gene therapy for adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
Gene therapy for primary adaptive immune deficiencies.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Beware the lymphopenia: A case of severe combined immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Advances in basic and clinical immunology in 2011.
diagnostic usage
unassigned
1
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: unanticipated benefits from the study of a rare immunodeficiency.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Gene Therapy for Severe Combined Immunodeficiency due to Adenosine Deaminase Deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Non-infectious Lung Disease in Patients with Adenosine Deaminase Deficient Severe Combined Immunodeficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Strategies for Retrovirus-Based Correction of Severe, Combined Immunodeficiency (SCID).
therapeutic application
unassigned
1
0
adenosine deaminase deficiency
Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency.
causal interaction
diagnostic usage
ongoing research
unassigned
4
4
2
0
adenosine deaminase deficiency
Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Delayed-onset adenosine deaminase deficiency: Strategies for an early diagnosis.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
3
0
adenosine deaminase deficiency
Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
Severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
Autoimmune dysregulation and purine metabolism in adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Severe phenotype of severe combined immunodeficiency caused by adenosine deaminase deficiency in a patient with a homozygous mutation due to uniparental disomy.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Expression of a functional human adenosine deaminase in transgenic tobacco plants.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Tandem mass spectrometry, but not T-cell receptor excision circle analysis, identifies newborns with late-onset adenosine deaminase deficiency.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Neutropenia and myeloid dysplasia in a patient with delayed-onset adenosine deaminase deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene therapy of primary T cell immunodeficiencies.
causal interaction
unassigned
2
0
adenosine deaminase deficiency
[Current status and future prospects of stem cell gene therapy for primary immunodeficiency].
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Newborn screening for severe combined immunodeficiency: an opportunity for intervention.
causal interaction
diagnostic usage
unassigned
3
4
0
adenosine deaminase deficiency
Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Preclinical demonstration of lentiviral vector-mediated correction of immunological and metabolic abnormalities in models of adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Human gene therapy: a brief overview of the genetic revolution.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Gene transfer into hematopoietic stem cells as treatment for primary immunodeficiency diseases.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
A short perspective on gene therapy: Clinical experience on gene therapy of gliomablastoma multiforme.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Genetic and biochemical consequences of adenosine deaminase deficiency in humans.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
1
1
4
adenosine deaminase deficiency
Host natural killer immunity is a key indicator of permissiveness for donor cell engraftment in patients with severe combined immunodeficiency.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Gene therapy for inherited immunodeficiency.
ongoing research
unassigned
1
0
adenosine deaminase deficiency
The treatment of adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
4
4
0
adenosine deaminase deficiency
Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
1
1
1
adenosine deaminase deficiency
[Adenosine deaminase 1 deficiency, an inborn error of metabolism underlying a severe form of combined immunodeficiency].
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Toll-like receptor signaling in primary immune deficiencies.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
Atypical Omenn Syndrome due to Adenosine Deaminase Deficiency.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Gene therapy for monogenic disorders of the bone marrow.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
IL-17 receptor A and adenosine deaminase 2 deficiency in siblings with recurrent infections and chronic inflammation.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Alveolar-like Stem Cell-derived Myb(neg) Macrophages Promote Recovery and Survival in Airway Disease.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase 2 deficiency presenting as spastic paraplegia and systemic vasculitis.
diagnostic usage
therapeutic application
unassigned
1
1
0
adenosine deaminase deficiency
Gene Therapy for the Treatment of Primary Immune Deficiencies.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Adenosine Deaminase Deficiency with a Novel Gene Mutation.
causal interaction
ongoing research
unassigned
4
2
0
adenosine deaminase deficiency
Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency.
causal interaction
ongoing research
therapeutic application
unassigned
3
1
4
0
adenosine deaminase deficiency
Investor Outlook: Rising from the Ashes; GSK's European Approval of Strimvelis for ADA-SCID.
causal interaction
therapeutic application
unassigned
1
4
0
adenosine deaminase deficiency
2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Advances of gene therapy for primary immunodeficiencies.
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
Extending the Clinical Phenotype of Adenosine Deaminase 2 Deficiency.
causal interaction
diagnostic usage
ongoing research
unassigned
2
3
2
0
adenosine deaminase deficiency
Adenosine Deaminase Deficiency - More Than Just an Immunodeficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Gene Therapy with Hematopoietic Stem Cells: The Diseased Bone Marrow's Point of View.
causal interaction
diagnostic usage
ongoing research
unassigned
2
3
2
0
adenosine deaminase deficiency
Retrospective TREC testing of newborns with Severe Combined Immunodeficiency and other primary immunodeficiency diseases.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Stroke as Initial Manifestation of Adenosine Deaminase 2 Deficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
2
0
adenosine deaminase deficiency
Pattern recognitions receptors in immunodeficiency disorders.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
Good Laboratory Practice Preclinical Safety Studies for GSK2696273 (MLV Vector-Based Ex Vivo Gene Therapy for Adenosine Deaminase Deficiency Severe Combined Immunodeficiency) in NSG Mice.
causal interaction
ongoing research
therapeutic application
unassigned
2
1
4
0
adenosine deaminase deficiency
Genetic Engineering and Manufacturing of Hematopoietic Stem Cells.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
Ultra-performance liquid chromatography-tandem mass spectrometry-based multiplex enzyme assay for six enzymes associated with hereditary hemolytic anemia.
ongoing research
unassigned
2
0
adenosine deaminase deficiency
Cicalese MP, Ferrua F, Castagnaro L, et al. Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency. Blood. 2016;128(1):45-54.
causal interaction
therapeutic application
unassigned
2
3
0
adenosine deaminase deficiency
Adenosine Deaminase 2 Deficiency: More Than Monogenic Vasculitis.
unassigned
0
adenosine deaminase deficiency
A case of severe combined immunodeficiency caused by adenosine deaminase deficiency with a new mutation.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Gene Therapy Approaches to Immunodeficiency.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
1
0
adenosine deaminase deficiency
Gene Therapy for Adenosine Deaminase Deficiency: A Comprehensive Evaluation of Short- and Medium-Term Safety.
causal interaction
therapeutic application
unassigned
1
4
0
adenosine deaminase deficiency
"Immune" Thrombocytopenia as Key Feature of a Novel ADA2 Deficiency Variant: Implication on Differential Diagnostics of ITP in Children.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Adenosine deaminase deficiency: a review.
causal interaction
unassigned
4
0
adenosine deaminase deficiency
Neutropenia among patients with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
4
0
adenosine deaminase deficiency
Recent developments and new frontiers in childhood arterial ischemic stroke.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Consensus approach for the management of severe combined immune deficiency caused by adenosine deaminase deficiency.
causal interaction
therapeutic application
unassigned
3
3
0
adenosine deaminase deficiency
Strimvelis® for Treating Severe Combined Immunodeficiency Caused by Adenosine Deaminase Deficiency: An Evidence Review Group Perspective of a NICE Highly Specialised Technology Evaluation.
causal interaction
therapeutic application
unassigned
2
1
0
adenosine deaminase deficiency
Chronic leg ulcer revealing adenosine deaminase 2 deficiency: an atypical presentation.
causal interaction
therapeutic application
unassigned
3
1
0
adenosine deaminase deficiency
Human adenosine deaminase 2 deficiency: A multi-faceted inborn error of immunity.
causal interaction
ongoing research
unassigned
3
2
0
adenosine deaminase deficiency
Variable Clinical Phenotypes and Relation of Interferon Signature with Disease Activity in ADA2 Deficiency.
unassigned
0
adenosine deaminase deficiency
Thirty Years of Followup in 3 Patients with Familial Polyarteritis Nodosa due to Adenosine Deaminase 2 Deficiency.
causal interaction
therapeutic application
unassigned
3
2
0
adenosine deaminase deficiency
Severe Combined Immunodeficiency: A Review for Neonatal Clinicians.
causal interaction
therapeutic application
unassigned
3
4
0
adenosine deaminase deficiency
The same mutation in a family with adenosine deaminase 2 deficiency.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
A clinical score to guide in decision making for monogenic type I IFNopathies.
diagnostic usage
unassigned
1
0
adenosine deaminase deficiency
Autoinflammatory diseases in childhood, part 1: monogenic syndromes.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
Urogenital Abnormalities in Adenosine Deaminase Deficiency.
causal interaction
ongoing research
unassigned
4
1
0
adenosine deaminase deficiency
A Rare Case of Adenosine Deaminase 2 Deficiency Presenting With Temporal Arteritis.
causal interaction
unassigned
1
0
adenosine deaminase deficiency
Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients.
causal interaction
unassigned
3
0
adenosine deaminase deficiency
The Many Faces of a Monogenic Autoinflammatory Disease: Adenosine Deaminase 2 Deficiency.
therapeutic application
unassigned
1
0
adenosine deaminase deficiency
Combined Immunodeficiency Disease and Adenosine Deaminase Deficiency. A Molecular Defect.
causal interaction
diagnostic usage
unassigned
4
1
0
adenosine kinase deficiency
Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides.
causal interaction
diagnostic usage
ongoing research
therapeutic application
4
2
3
1
adenylate kinase deficiency
Hereditary disorders of erythrocyte enzymes in non-glycolytic metabolic pathways.
causal interaction
therapeutic application
unassigned
4
1
0
Adrenoleukodystrophy
Genotoxicity of retroviral hematopoietic stem cell gene therapy.
therapeutic application
unassigned
3
0
Adrenoleukodystrophy
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity.
causal interaction
therapeutic application
unassigned
3
1
0
Agammaglobulinemia
A case of hypogammaglobulinemia with enteroviral meningoencephalitis, associated with increased adenosine deaminase in cerebrospinal fluid.
causal interaction
diagnostic usage
unassigned
3
4
0
Agammaglobulinemia
Observational, hypothesis-driven and genomics research strategies for analyzing inherited differences in responses to infectious diseases.
causal interaction
unassigned
4
0
Agammaglobulinemia
Dysregulation in B-cell responses and T follicular helper cell function in ADA2 deficiency patients.
causal interaction
unassigned
3
0
AIDS-Related Complex
Enhancement of erythrocytic adenosine deaminase following treatment of AIDS-related complex/AIDS patients with zidovudine.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
2
1
2
Airway Obstruction
Metabolic consequences of adenosine deaminase deficiency in mice are associated with defects in alveogenesis, pulmonary inflammation, and airway obstruction.
causal interaction
unassigned
4
0
Alopecia Areata
Oxidative Stress Biomarkers and Adenosine Deaminase over the Alopecic Area of the Patients with Alopecia Areata.
causal interaction
therapeutic application
unassigned
2
1
0
alpha-Thalassemia
Acquired hemoglobin H disease associated with idiopathic myelofibrosis and hereditary adenosine deaminase deficiency.
unassigned
0
Alzheimer Disease
Purine-related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology.
diagnostic usage
ongoing research
unassigned
3
1
0
amidase deficiency
Adenosine as a prostaglandin antagonist. Possible mechanism of the defect in combined immunodeficiency disease due to adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
3
1
0
amidase deficiency
[Molecular pathology of immunological deficiency. Apropos of adenosine deaminase deficiency and nucleoside phosphorylase deficiency]
causal interaction
unassigned
4
0
amidase deficiency
Differential deoxyadenosine toxicity to immature rabbit cartilage in vitro. A model for the chondro-osseous dysplasia of adenosine deaminase deficiency.
ongoing research
unassigned
3
0
amidase deficiency
Effects of deoxycoformycin in mice. III. A murine model reproducing multi-system pathology of human adenosine deaminase deficiency.
ongoing research
unassigned
4
0
amidase deficiency
Partial resolution of bone lesions. A child with severe combined immunodeficiency disease and adenosine deaminase deficiency after enzyme-replacement therapy.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
amidase deficiency
Glaxo/MRS Young Investigator Medal. Molecular studies on adenosine deaminase deficiency and hereditary haemorrhagic telangiectasia.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
4
1
1
amidase deficiency
Amendment to Clinical Research Project. Project 90-C-195. April 1, 1993. Treatment of severe combined immunodeficiency disease (SCID) due to adenosine deaminase deficiency with autologous lymphocytes transduced with a human ADA gene.
causal interaction
therapeutic application
unassigned
3
1
0
amidase deficiency
Cicalese MP, Ferrua F, Castagnaro L, et al. Update on the safety and efficacy of retroviral gene therapy for immunodeficiency due to adenosine deaminase deficiency. Blood. 2016;128(1):45-54.
causal interaction
therapeutic application
unassigned
2
3
0
Amyloidosis
Renal Amyloidosis in Deficiency of Adenosine Deaminase 2: Successful Experience With Canakinumab.
causal interaction
unassigned
4
0
Amyotrophic Lateral Sclerosis
Co-Occurrence of TDP-43 Mislocalization with Reduced Activity of an RNA Editing Enzyme, ADAR2, in Aged Mouse Motor Neurons.
causal interaction
unassigned
3
0
Amyotrophic Lateral Sclerosis
The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients.
causal interaction
unassigned
2
0
Amyotrophic Lateral Sclerosis
Unique nuclear vacuoles in the motor neurons of conditional ADAR2-knockout mice.
unassigned
0
Amyotrophic Lateral Sclerosis
Autophagy in spinal motor neurons of conditional ADAR2-knockout mice: An implication for a role of calcium in increased autophagy flux in ALS.
causal interaction
therapeutic application
unassigned
1
1
0
Amyotrophic Lateral Sclerosis
Cell death cascade and molecular therapy in ADAR2-deficient motor neurons of ALS.
therapeutic application
unassigned
1
0
Amyotrophic Lateral Sclerosis
Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis.
therapeutic application
unassigned
1
0
Amyotrophic Lateral Sclerosis
[Perampanel for Sporadic Amyotrophic Lateral Sclerosis].
causal interaction
unassigned
2
0
Anaphylaxis
Effect of adenosine on histamine release and atrioventricular conduction during guinea pig cardiac anaphylaxis.
unassigned
0
Anemia
Evaluation of the expanded newborn screening program in New York City.
causal interaction
diagnostic usage
unassigned
2
1
0
Anemia
Increased adenosine deaminase activity in a patient with cartilage-hair hypoplasia.
unassigned
0
Anemia
[Influence of iron deficiency anemia on development of thymus and spleen and adenosine deaminase activity in rats]
ongoing research
unassigned
3
0
Anemia
Erythrocyte disorders of purine and pyrimidine metabolism.
causal interaction
unassigned
4
0
Anemia
High adenosine deaminase level among healthy probands of Diamond Blackfan anemia (DBA) cosegregates with the DBA gene region on chromosome 19q13. The DBA Working Group of Société d'Immunologie Pédiatrique (SHIP).
unassigned
0
Anemia
[Diamond-Blackfan anemia confirmed by RPS19 gene mutation analysis: a case study and literature review of Korean patients]
causal interaction
diagnostic usage
unassigned
1
1
0
Anemia
Erythrocyte adenosine deaminase levels are elevated in Diamond Blackfan anemia but not in the 5q- syndrome.
unassigned
0
Anemia
Role of adenosine signaling in coordinating cardiomyocyte function and coronary vascular growth in chronic fetal anemia.
causal interaction
unassigned
3
0
Anemia, Aplastic
Pearson bone marrow-pancreas syndrome with insulin-dependent diabetes, progressive renal tubulopathy, organic aciduria and elevated fetal haemoglobin caused by deletion and duplication of mitochondrial DNA.
diagnostic usage
ongoing research
unassigned
1
2
0
Anemia, Diamond-Blackfan
Elevated red cell adenosine deaminase activity: a marker of disordered erythropoiesis in Diamond-Blackfan anaemia and other haematologic diseases.
causal interaction
diagnostic usage
unassigned
1
1
0
Anemia, Diamond-Blackfan
Comparative activity of erythrocyte adenosine deaminase and orotidine decarboxylase in Diamond-Blackfan anemia.
unassigned
0
Anemia, Diamond-Blackfan
Transient erythrophagocytosis in Diamond-Blackfan anemia.
causal interaction
therapeutic application
unassigned
2
1
0
Anemia, Diamond-Blackfan
High adenosine deaminase level among healthy probands of Diamond Blackfan anemia (DBA) cosegregates with the DBA gene region on chromosome 19q13. The DBA Working Group of Société d'Immunologie Pédiatrique (SHIP).
unassigned
0
Anemia, Diamond-Blackfan
Nomimmune hydrops fetalis due to Diamond-Blackfan anemia.
causal interaction
diagnostic usage
unassigned
1
4
0
Anemia, Diamond-Blackfan
Erythrocyte adenosine deaminase: diagnostic value for Diamond-Blackfan anaemia.
diagnostic usage
unassigned
2
0
Anemia, Diamond-Blackfan
Erythrocyte adenosine deaminase levels are elevated in Diamond Blackfan anemia but not in the 5q- syndrome.
unassigned
0
Anemia, Hemolytic
Recent progress in the molecular genetic analysis of erythroenzymopathy.
causal interaction
unassigned
1
0
Anemia, Hemolytic
Erythrocyte-specific overproduction of adenosine deaminase: molecular genetic studies.
causal interaction
unassigned
2
0
Anemia, Hemolytic
Autosomal dominant hemolytic anemia and adenosine deaminase overproduction.
diagnostic usage
ongoing research
unassigned
1
2
0
Anemia, Hemolytic
[Pathophysiology and laboratory tests of hemolytic anemia: with special reference to erythroenzymopathies]
causal interaction
unassigned
4
0
Anemia, Hemolytic
Erythrocyte adenosine deaminase overproduction in hereditary hemolytic anemia.
causal interaction
therapeutic application
unassigned
1
1
0
Anemia, Hemolytic
Adenosine deaminase (ADA) overproduction associated with congenital hemolytic anemia: case report and molecular analysis.
causal interaction
diagnostic usage
unassigned
1
1
0
Anemia, Hemolytic
Increased erythrocyte adenosine deaminase activity without haemolytic anaemia.
diagnostic usage
unassigned
1
0
Anemia, Hemolytic
Three kinds of foamy cells in the spleen: comparative histochemical and ultrastructural studies.
ongoing research
unassigned
4
0
Anemia, Hemolytic
Erythrocyte disorders of purine and pyrimidine metabolism.
causal interaction
unassigned
4
0
Anemia, Hemolytic
Studies on pyruvate kinase deficiency, pyrimidine 5-'nucleotidase deficiency and adenosine deaminase overproduction.
causal interaction
ongoing research
unassigned
3
3
0
Anemia, Hemolytic
Biochemical study of a case of hemolytic anemia with increased (85-fold) red cell adenosine deaminase.
unassigned
0
Anemia, Hemolytic
ATP depletion as a consequence of adenosine deaminase inhibition in man.
causal interaction
diagnostic usage
therapeutic application
unassigned
2
3
3
0
Anemia, Hemolytic
Overproduction of structurally normal enzyme in man: hereditary haemolytic anaemia with increased red cell adenosine deaminase activity.
ongoing research
therapeutic application
unassigned
3
1
0
Anemia, Hemolytic
Biochemical study of a case of hemolytic anemia with increased (85 fold) red cell adenosine deaminase.
unassigned
0
Anemia, Hemolytic
Hereditary disorders of erythrocyte enzymes in non-glycolytic metabolic pathways.
causal interaction
therapeutic application
unassigned
4
1
0
Anemia, Hemolytic
Hereditary overexpression of adenosine deaminase in erythrocytes: studies in erythroid cell lines and transgenic mice.
ongoing research
unassigned
3
0
Anemia, Hemolytic
Hereditary overexpression of adenosine deaminase in erythrocytes: evidence for a cis-acting mutation.
causal interaction
unassigned
1
0
Anemia, Hemolytic
Molecular basis of erythroenzymopathies associated with hereditary hemolytic anemia: tabulation of mutant enzymes.
causal interaction
unassigned
4
0
Anemia, Hemolytic
Red cell enzymopathies as a model of inborn errors of metabolism.
causal interaction
unassigned
4
0
Anemia, Hemolytic, Autoimmune
Heterozygous Mutation in Adenosine Deaminase Gene in a Patient With Severe Lymphopenia Following Corticosteroid Treatment of Autoimmune Hemolytic Anemia.
causal interaction
therapeutic application
unassigned
3
3
0
Anemia, Hemolytic, Congenital
A case of red-cell adenosine deaminase overproduction associated with hereditary hemolytic anemia found in Japan.
causal interaction
therapeutic application
unassigned
1
1
0
Anemia, Hemolytic, Congenital
Hereditary hemolytic anemia with increased red cell adenosine deaminase (45- to 70-fold) and decreased adenosine triphosphate.
diagnostic usage
unassigned
1
0
Anemia, Hemolytic, Congenital
Erythrocyte adenosine deaminase overproduction in hereditary hemolytic anemia.
causal interaction
therapeutic application
unassigned
1
1
0
Anemia, Hemolytic, Congenital
Elevated adenosine deaminase activity and hereditary hemolytic anemia. Evidence for abnormal translational control of protein synthesis.
ongoing research
therapeutic application
unassigned
2
1
0
Anemia, Hemolytic, Congenital
Adenosine deaminase (ADA) overproduction associated with congenital hemolytic anemia: case report and molecular analysis.
causal interaction
diagnostic usage
unassigned
1
1
0
Anemia, Hemolytic, Congenital
Elevated erythrocyte adenosine deaminase activity in congenital hypoplastic anemia.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
2
4
0
Anemia, Hemolytic, Congenital
Purification and properties of adenosine deaminase in normal and hereditary hemolytic anemia with increased red cell activity.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
4
1
0
Anemia, Hypoplastic, Congenital
Elevated erythrocyte adenosine deaminase activity in congenital hypoplastic anemia.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
2
4
0
Anemia, Hypoplastic, Congenital
Complexities of genetic diagnosis illustrated by an atypical case of congenital hypoplastic anemia.
causal interaction
unassigned
2
0
Anemia, Iron-Deficiency
[Influence of iron deficiency anemia on development of thymus and spleen and adenosine deaminase activity in rats]
ongoing research
unassigned
3
0
Anemia, Pernicious
Adenosine deaminase activity in gastric mucosa of pernicious anemia patients. Effect of treatment with cyanocobalamin (vitamin B12).
therapeutic application
unassigned
3
0
Anemia, Sickle Cell
Evaluation of the expanded newborn screening program in New York City.
causal interaction
diagnostic usage
unassigned
2
1
0
Anemia, Sideroblastic
Elevated erythrocyte adenosine deaminase activity in a patient with primary acquired sideroblastic anemia.
causal interaction
diagnostic usage
unassigned
3
3
0
Angina, Stable
Adenosine deaminase activity in blood of patients with stable angina pectoris.
diagnostic usage
ongoing research
therapeutic application
unassigned
3
3
1
0
Angina, Unstable
5'-nucleotidase and adenosine deaminase activities in blood of patients with unstable angina pectoris.
diagnostic usage
ongoing research
unassigned
3
2
0
Anthrax
Serum adenosine deaminase activity in cutaneous anthrax.
causal interaction
diagnostic usage
unassigned
3
2
0
Antiphospholipid Syndrome
Novel CECR1 gene mutations causing deficiency of adenosine deaminase 2, mimicking antiphospholipid syndrome.
causal interaction
unassigned
3
0
Appendicitis
Serum adenosine deaminase levels in diagnosis of acute appendicitis.
causal interaction
diagnostic usage
unassigned
1
4
0
Arrhythmias, Cardiac
Adenosine deaminase and BW A1433U attenuate hypoxia-induced ventricular ectopy.
causal interaction
therapeutic application
unassigned
2
1
0
Arrhythmias, Cardiac
Gene therapy in cardiac arrhythmias.
causal interaction
therapeutic application
unassigned
3
1
0
Arteriosclerosis
[Peripheral blood albumin level in significantly correlated with the severity of atherosclerosis in hypertensive patients].
causal interaction
diagnostic usage
unassigned
3
3
0
Arthritis
[Adenosine deaminase activity in tuberculous arthritis and other monoarthritis]
diagnostic usage
unassigned
3
0
Arthritis
[Adenosine deaminase in tuberculous arthritis]
causal interaction
diagnostic usage
unassigned
2
1
0
Arthritis
[Activity of adenosine deaminase in the serum of children ill with rheumatism and chronic progressive arthritis]
causal interaction
diagnostic usage
unassigned
2
3
0
Arthritis
Synovial fluid adenosine deaminase activity to diagnose tuberculous septic arthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
1
2
3
0
Arthritis
Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis.
diagnostic usage
unassigned
4
0
Arthritis
A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge.
diagnostic usage
unassigned
4
0
Arthritis
Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: A possible anti-arthritic mechanism of eugenol.
ongoing research
unassigned
2
0
Arthritis
A clinical score to guide in decision making for monogenic type I IFNopathies.
diagnostic usage
unassigned
1
0
Arthritis
Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
unassigned
0
Arthritis
Autoinflammatory diseases in childhood, part 1: monogenic syndromes.
causal interaction
unassigned
3
0
Arthritis, Experimental
Effects of pentostatin (2'deoxycoformycin), an inhibitor of adenosine deaminase, on type II collagen-induced arthritis in rats.
ongoing research
therapeutic application
unassigned
4
4
0
Arthritis, Experimental
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
diagnostic usage
ongoing research
therapeutic application
unassigned
2
2
1
0
Arthritis, Gouty
[Adenosine deaminase activity in the lymphocytes of patients with gouty arthritis]
diagnostic usage
unassigned
1
0
Arthritis, Infectious
Synovial fluid adenosine deaminase activity to diagnose tuberculous septic arthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
1
2
3
0
Arthritis, Juvenile
Adenosine deaminase activity and its isoenzyme pattern in patients with juvenile rheumatoid arthritis and systemic lupus erythematosus.
causal interaction
unassigned
3
0
Arthritis, Juvenile
Management of Gaucher disease in a post-communist transitional health care system: Croatian experience.
causal interaction
ongoing research
therapeutic application
unassigned
3
3
3
0
Arthritis, Juvenile
[Diagnosis and treatment of Gaucher disease in Croatia]
causal interaction
diagnostic usage
therapeutic application
unassigned
3
3
3
0
Arthritis, Juvenile
Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis.
diagnostic usage
unassigned
4
0
Arthritis, Juvenile
A fatal case of tuberculous meningitis in a child with juvenile idiopathic arthritis: a diagnostic challenge.
diagnostic usage
unassigned
4
0
Arthritis, Juvenile
A clinical score to guide in decision making for monogenic type I IFNopathies.
diagnostic usage
unassigned
1
0
Arthritis, Juvenile
Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
unassigned
0
Arthritis, Reactive
Serum and synovial fluid adenosine deaminase activity in patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.
causal interaction
diagnostic usage
unassigned
3
4
0
Arthritis, Rheumatoid
Purine enzyme levels in rheumatoid arthritis.
ongoing research
unassigned
4
0
Arthritis, Rheumatoid
Serum and synovial fluid adenosine deaminase activity in patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis.
causal interaction
diagnostic usage
unassigned
3
4
0
Arthritis, Rheumatoid
[Adenosine deaminase activity in levamisole treatment of patients with rheumatoid arthritis]
causal interaction
therapeutic application
unassigned
3
4
0
Arthritis, Rheumatoid
Three kinds of foamy cells in the spleen: comparative histochemical and ultrastructural studies.
ongoing research
unassigned
4
0
Arthritis, Rheumatoid
Plasma adenosine deaminase activity in children with rheumatic fever and rheumatoid arthritis.
diagnostic usage
ongoing research
unassigned
1
2
0
Arthritis, Rheumatoid
Pleural fluid adenosine deaminase in rheumatoid arthritis and systemic lupus erythematosus.
causal interaction
unassigned
2
0
Arthritis, Rheumatoid
Effect of cyclosporin on the activity of cytidine deaminase and adenosine deaminase in the serum and polymorphonuclear leukocytes of patients with rheumatoid arthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
2
3
3
0
Arthritis, Rheumatoid
Correlations between matrix metalloproteinase-9 and adenosine deaminase isozymes in synovial fluid from patients with rheumatoid arthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
3
3
2
0
Arthritis, Rheumatoid
Biochemical analysis of pleural fluid: what should we measure?
causal interaction
diagnostic usage
unassigned
3
3
0
Arthritis, Rheumatoid
Serum interleukin-12, interleukin-15, soluble CD26, and adenosine deaminase in patients with rheumatoid arthritis.
diagnostic usage
ongoing research
unassigned
1
1
0
Arthritis, Rheumatoid
Specific increase in enzymatic activity of adenosine deaminase 1 in rheumatoid synovial fibroblasts.
causal interaction
diagnostic usage
unassigned
1
3
0
Arthritis, Rheumatoid
Correlation of serum levels of adenosine deaminase activity and its isoenzymes with disease activity in rheumatoid arthritis.
causal interaction
diagnostic usage
unassigned
1
4
0
Arthritis, Rheumatoid
[Aberrant over-expression of adenosine deaminase and its significance on rheumatoid arthritis]
causal interaction
ongoing research
unassigned
3
2
0
Arthritis, Rheumatoid
Assessment of adenosine deaminase levels in rheumatoid arthritis patients receiving anti-TNF-alpha therapy.
causal interaction
therapeutic application
unassigned
3
4
0
Arthritis, Rheumatoid
A study of adenosine-deaminase genetic polymorphism in rheumatoid arthritis.
causal interaction
therapeutic application
unassigned
3
1
0
Arthritis, Rheumatoid
Adenosine deaminase and C-reactive protein in diagnosing and monitoring of rheumatoid arthritis.
diagnostic usage
ongoing research
unassigned
1
1
0
Arthritis, Rheumatoid
Serum adenosine deaminase may predict disease activity in rheumatoid arthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
3
0
Arthritis, Rheumatoid
Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders.
ongoing research
unassigned
2
0
Arthritis, Rheumatoid
Comparison of adenosine deaminase levels in serum and synovial fluid between patients with rheumatoid arthritis and osteoarthritis.
causal interaction
diagnostic usage
ongoing research
unassigned
1
4
4
0
Arthritis, Rheumatoid
Activities of enzymes that hydrolyze adenine nucleotides in lymphocytes from patients with rheumatoid arthritis.
ongoing research
unassigned
2
0
Arthritis, Rheumatoid
Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
4
0
Arthritis, Rheumatoid
Serum Adenosine Deaminase Level is High But Not Related with Disease Activity Parameters in Patients with Rheumatoid Arthritis.
causal interaction
diagnostic usage
unassigned
3
4
0
Arthritis, Rheumatoid
Serum Adenosine Deaminase as Inflammatory Marker in Rheumatoid Arthritis.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
1
0
Arthritis, Rheumatoid
Adenosine Deaminase activity and HLA-DRB as diagnostic markers for Rheumatoid Arthritis.
causal interaction
diagnostic usage
unassigned
1
4
0
Asthma
[The effect of aminophylline on plasma oxypurines in patients with bronchial asthma or cor pulmonale]
diagnostic usage
ongoing research
unassigned
3
3
0
Asthma
A genetic basis for heterogeneity of asthma syndrome in pediatric ages: adenosine deaminase phenotypes.
causal interaction
unassigned
1
0
Asthma
Cooperative effect of adenosine deaminase and ABO-secretor genetic complex on susceptibility to childhood asthma.
ongoing research
therapeutic application
unassigned
2
1
0
Asthma
[Enzymes of purine metabolism of lymphocytes and eosinophiles in bronchial asthma]
causal interaction
diagnostic usage
ongoing research
unassigned
1
4
2
0
Asthma
Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: a study of adenosine deaminase and MN blood group genetic polymorphisms.
causal interaction
diagnostic usage
ongoing research
therapeutic application
2
2
2
2
Asthma
Genetic polymorphism and TH1/TH2 orientation.
diagnostic usage
ongoing research
unassigned
1
1
0
Asthma
Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice.
diagnostic usage
ongoing research
unassigned
1
2
0
Asthma
Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma.
therapeutic application
unassigned
1
0
Asthma
The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils.
causal interaction
therapeutic application
unassigned
1
2
0
Asthma
Alveolar-like Stem Cell-derived Myb(neg) Macrophages Promote Recovery and Survival in Airway Disease.
causal interaction
unassigned
3
0
Asthma
Aberrant purine metabolism in allergic asthma revealed by plasma metabolomics.
causal interaction
therapeutic application
unassigned
3
1
0
Astrocytoma
Novel metabolic aspects related to adenosine deaminase inhibition in a human astrocytoma cell line.
diagnostic usage
ongoing research
unassigned
3
4
0
Astrocytoma
The combination of adenosine deaminase inhibition and deoxyadenosine induces apoptosis in a human astrocytoma cell line.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
3
2
0
Atherosclerosis
Extracellular Purine Metabolism in Blood Vessels (Part II): Activity of Ecto-Enzymes in Blood Vessels of Patients With Abdominal Aortic Aneurysm.
causal interaction
unassigned
3
0
Atherosclerosis
Increased activity of vascular adenosine deaminase in atherosclerosis and therapeutic potential of its inhibition.
causal interaction
ongoing research
therapeutic application
unassigned
3
4
4
0
Atrial Fibrillation
A novel association of adenosine deaminase with paroxysmal atrial fibrillation: a propensity score analysis from a case-control study.
causal interaction
ongoing research
unassigned
1
3
0
Atrioventricular Block
Effect of adenosine on histamine release and atrioventricular conduction during guinea pig cardiac anaphylaxis.
unassigned
0
Atrioventricular Block
On augmentation of adenosine-mediated negative dromotropic effect by K+ released during myocardial ischemia.
unassigned
0
Autoimmune Diseases
[Pathogenetic significance of adenosine deaminase in autoimmune diseases]
diagnostic usage
therapeutic application
unassigned
1
1
0
Autoimmune Diseases
Adenosine deaminase activity in plasma and blood cells of patients with haematological and autoimmune diseases.
causal interaction
diagnostic usage
ongoing research
therapeutic application
2
3
4
1
Autoimmune Diseases
Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis.
causal interaction
therapeutic application
unassigned
3
1
0
Autoimmune Diseases
Serum adenosine deaminase activity is increased in systemic lupus erythematosus patients and correlated with disease activity.
causal interaction
diagnostic usage
unassigned
3
3
0
Autoimmune Diseases
Polyserositis: a diagnostic challenge.
causal interaction
diagnostic usage
unassigned
3
4
0
Bacterial Infections
The chondro-osseous dysplasia of adenosine deaminase deficiency with severe combined immunodeficiency.
causal interaction
therapeutic application
unassigned
3
1
0
Bacterial Infections
Significance of adenosine deaminase activity and its isoenzymes in tuberculous effusions.
causal interaction
diagnostic usage
unassigned
2
1
0
Bacterial Infections
The diagnostic and prognostic value of adenosine deaminase in tuberculous pericarditis.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
1
0
Bacterial Infections
[Clinical significance of cytokine measurement in pleural effusion]
diagnostic usage
ongoing research
unassigned
1
2
0
Behcet Syndrome
Current concepts in the etiology and treatment of Behçet disease.
causal interaction
therapeutic application
unassigned
1
1
0
Bernard-Soulier Syndrome
A self-controlled comparative clinical trial to explore the effectiveness of three topical hemostatic agents for stopping severe epistaxis in pediatrics with inherited coagulopathies.
diagnostic usage
therapeutic application
unassigned
4
1
0
Blast Crisis
Adenosine deaminase activity in leukaemia.
causal interaction
diagnostic usage
unassigned
3
3
0
Blast Crisis
[Enzymatic markers in chronic myeloleukemia and their importance for identifying a blast crisis]
unassigned
0
Blast Crisis
Differential expression of adenosine deaminase isozymes in acute leukemia.
causal interaction
diagnostic usage
ongoing research
unassigned
1
4
4
0
Blast Crisis
Adenosine deaminase and ecto-5'-nucleotidase activities in various leukemias with special reference to blast crisis: significance of ecto-5'-nucleotidase in lymphoid blast crisis of chronic myeloid leukemia.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
4
3
1
Blast Crisis
5'nucleotidase, adenosine deaminase and purine nucleoside phosphorylase activities in acute leukaemia.
diagnostic usage
ongoing research
unassigned
3
3
0
Blast Crisis
A biological marker model for predicting disease transitions.
diagnostic usage
unassigned
4
0
Blast Crisis
[Certain biochemical features of leukocytes in blast crisis of chronic myelogenous leukemia]
diagnostic usage
ongoing research
unassigned
1
1
0
Bone Diseases, Developmental
Partial resolution of bone lesions. A child with severe combined immunodeficiency disease and adenosine deaminase deficiency after enzyme-replacement therapy.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
Bone Marrow Failure Disorders
Hematologic Manifestations of Deficiency of Adenosine Deaminase 2 (DADA2) and Response to Tumor Necrosis Factor Inhibition in DADA2-Associated Bone Marrow Failure.
causal interaction
therapeutic application
unassigned
3
1
0
Bone Marrow Failure Disorders
Vasculopathy, Immunodeficiency, and Bone Marrow Failure: The Intriguing Syndrome Caused by Deficiency of Adenosine Deaminase 2.
causal interaction
unassigned
3
0
Bone Marrow Failure Disorders
Novel ADA2 mutation presenting with neutropenia, lymphopenia and bone marrow failure in patients with deficiency in adenosine deaminase 2 (DADA2).
causal interaction
unassigned
4
0
Bone Marrow Failure Disorders
Deficiency of adenosine deaminase 2 (DADA2) in Adults and Children: Experience from India.
causal interaction
unassigned
2
0
Boutonneuse Fever
[Adenosine deaminase and boutonneuse fever]
unassigned
0
Boutonneuse Fever
[Serum adenosine deaminase activity in Mediterranean spotted fever]
diagnostic usage
unassigned
1
0
Brain Diseases
Adenosine deaminase and protein pattern in serum and cerebrospinal fluid in experimental manganese encephalopathy.
unassigned
0
Brain Diseases
Biallelic variants in ADARB1, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.
causal interaction
unassigned
3
0
Brain Infarction
[Juvenile familial vertebrobasilar brain infarctions due to adenosine deaminase 2 deficiency].
unassigned
0
Brain Injuries
A1 adenosine receptors mediate hypoxia-induced ventriculomegaly.
ongoing research
unassigned
1
0
Brain Ischemia
Neuroprotective effects of adenosine deaminase in the striatum.
ongoing research
therapeutic application
unassigned
2
1
0
Brain Neoplasms
Serum adenosine deaminase activity in brain tumours.
diagnostic usage
ongoing research
unassigned
4
2
0
Brain Neoplasms
Gene transfer and antisense nucleic acid techniques.
causal interaction
therapeutic application
unassigned
3
4
0
Brain Neoplasms
Hematopoietic stem cell gene therapy with drug resistance genes: an update.
causal interaction
therapeutic application
unassigned
4
2
0
Breast Diseases
Diagnostic value of adenosine deaminase activity in benign and malignant breast tumors.
causal interaction
diagnostic usage
ongoing research
unassigned
1
4
4
0
Breast Neoplasms
Purine salvage enzyme activities in normal and neoplastic human tissues.
causal interaction
diagnostic usage
ongoing research
unassigned
4
4
3
0
Breast Neoplasms
[Activity of the enzymes of DNA metabolism in the blood of patients with breast cancer]
causal interaction
diagnostic usage
therapeutic application
unassigned
3
3
2
0
Breast Neoplasms
[Use of enzyme test in chemotherapy of patients with cancer of the breast]
diagnostic usage
ongoing research
unassigned
4
2
0
Breast Neoplasms
Serum adenosine deaminase, 5'-nucleotidase & alkaline phosphatase in breast cancer patients.
diagnostic usage
ongoing research
unassigned
4
4
0
Breast Neoplasms
Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions.
ongoing research
therapeutic application
unassigned
4
1
0
Breast Neoplasms
Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk.
ongoing research
unassigned
2
0
Breast Neoplasms
Molecular characterization as a target for cancer therapy in relation to orphan status disorders (Review).
causal interaction
therapeutic application
unassigned
3
4
0
Breast Neoplasms
Hematopoietic stem cell gene therapy with drug resistance genes: an update.
causal interaction
therapeutic application
unassigned
4
2
0
Breast Neoplasms
Adenosine deaminase activity in the serum and malignant tumors of breast cancer: the assessment of isoenzyme ADA1 and ADA2 activities.
causal interaction
diagnostic usage
ongoing research
unassigned
2
4
4
0
Breast Neoplasms
[Lactate dehydrogenase, adenosine deaminase and thymidine phosphorylase activity of blood and tissues in breast tumor patients]
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Breast Neoplasms
Diagnostic value of adenosine deaminase activity in benign and malignant breast tumors.
causal interaction
diagnostic usage
ongoing research
unassigned
1
4
4
0
Breast Neoplasms
Oxidative stress and its relationship with adenosine deaminase activity in various stages of breast cancer.
causal interaction
ongoing research
unassigned
2
3
0
Breast Neoplasms
Urtica dioica inhibits cell growth and induces apoptosis by targeting Ornithine decarboxylase and Adenosine deaminase as key regulatory enzymes in adenosine and polyamines homeostasis in human breast cancer cell lines.
diagnostic usage
ongoing research
therapeutic application
unassigned
3
4
1
0
Breast Neoplasms
Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms.
causal interaction
ongoing research
therapeutic application
unassigned
1
4
2
0
Bronchitis, Chronic
[Changes in adenosine deaminase and antioxidative enzyme activity in patients with lung diseases of dust etiology]
causal interaction
diagnostic usage
ongoing research
therapeutic application
2
3
4
1
Bronchopulmonary Dysplasia
Adenosine deaminase levels in premature infants with respiratory distress syndrome and bronchopulmonary dysplasia.
causal interaction
unassigned
3
0
Brucellosis
[Activity of adenosine deaminase in acute brucellosis and complicated brucellosis]
causal interaction
therapeutic application
unassigned
3
2
0
Brucellosis
Increased pleural fluid adenosine deaminase in brucellosis is difficult to differentiate from tuberculosis.
diagnostic usage
unassigned
2
0
Brucellosis
Primary peritonitis due to brucellosis mimicking tuberculous peritonitis.
causal interaction
unassigned
3
0
Burkitt Lymphoma
Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase.
causal interaction
therapeutic application
unassigned
2
3
0
Candidiasis
Severe combined immunodeficiency disease with adenosine deaminase deficiency.
causal interaction
diagnostic usage
unassigned
4
1
0
Candidiasis
Properties of adenosine deaminase from Candida albicans.
unassigned
0
Carcinogenesis
Behaviour of adenylic acid and adenosine deaminase in spontaneous mammary carcinogenesis in mice.
ongoing research
therapeutic application
unassigned
3
1
0
Carcinogenesis
[Influence of thymostimulin on the activity of certain enzymes of adenosine and AMP metabolism in lymphocytes of rats with mammary cancer]
causal interaction
ongoing research
therapeutic application
unassigned
2
2
1
0
Carcinogenesis
The lymphocyte activity of adenosine deaminase and enzymes of AMP metabolism in mammary carcinogenesis: the effect of thymostimulin.
ongoing research
therapeutic application
unassigned
4
1
0
Carcinogenesis
Adenylic acid and adenosine deaminase activities in rat livers during azo-dye carcinogenesis.
ongoing research
unassigned
2
0
Carcinogenesis
Three Nordic berries inhibit intestinal tumorigenesis in multiple intestinal neoplasia/+ mice by modulating beta-catenin signaling in the tumor and transcription in the mucosa.
causal interaction
unassigned
2
0
Carcinogenesis
Berries as chemopreventive dietary constituents--a mechanistic approach with the ApcMin/+ mouse.
causal interaction
diagnostic usage
ongoing research
unassigned
1
2
2
0
Carcinoma
[Adenosine deaminase activity in hepatomas of varying degrees of malignancy]
diagnostic usage
unassigned
3
0
Carcinoma
Studies of lymphocyte adenosine deaminase activity in patients with renal and transitional cell carcinoma.
diagnostic usage
ongoing research
unassigned
1
2
0
Carcinoma
Adenosine deaminase activity in a transplantable murine renal adenocarcinoma.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
4
1
0
Carcinoma
Adenosine deaminase activity in patients with carcinoma of the bladder.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
3
0
Carcinoma
Adenosine deaminase activity in patients with renal adenocarcinoma.
diagnostic usage
ongoing research
therapeutic application
unassigned
4
4
1
0
Carcinoma
[Use of the study of DNA metabolism enzyme activities as a test system in the treatment of breast cancer]
diagnostic usage
ongoing research
unassigned
3
2
0
Carcinoma
[Effect of GMDP encapsulated into liposomes on metastatic spread of Lewis lung carcinoma]
ongoing research
unassigned
3
0
Carcinoma
[Antimetastatic action of bacterial endotoxins and changes in the activity of the enzymes of purine metabolism in macrophages]
ongoing research
therapeutic application
unassigned
4
2
0
Carcinoma
[Adenosine metabolism in lymphocytes and neurochemical stressor reactions in mice with metastatic Lewis carcinoma after surgical removal of the tumor]
ongoing research
unassigned
3
0
Carcinoma
Adenosine deaminase and purine phosphorylase activities in lymphocytes and red blood cells of patients with carcinoma of the larynx.
causal interaction
diagnostic usage
ongoing research
unassigned
2
4
4
0
Carcinoma
Characterization of adenosine deaminase from normal human epidermis and squamous cell carcinoma of the skin.
diagnostic usage
ongoing research
unassigned
2
4
0
Carcinoma
Adenosine deaminase activity in peripheral lymphocytes of patients with gynaecologic malignancies.
causal interaction
diagnostic usage
therapeutic application
unassigned
1
3
1
0
Carcinoma
Purine metabolizing enzymes in lymphocytes from patients with solid tumors.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Carcinoma
Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral blood cells of patients with neoplastic diseases. I. Bronchogenic carcinoma.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
3
4
1
Carcinoma
9-Deazaadenosine--a new potent antitumor agent.
diagnostic usage
ongoing research
unassigned
3
2
0
Carcinoma
Gastrointestinal tumor markers, other than carcinoembryonic antigen, and alpha fetal protein.
diagnostic usage
ongoing research
unassigned
4
2
0
Carcinoma
Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.
diagnostic usage
ongoing research
unassigned
3
4
0
Carcinoma
Purine enzyme profile in human colon-carcinoma cell lines and differential sensitivity to deoxycoformycin and 2'-deoxyadenosine in combination.
ongoing research
unassigned
4
0
Carcinoma
Serum adenosine deaminase, 5'-nucleotidase & alkaline phosphatase in breast cancer patients.
diagnostic usage
ongoing research
unassigned
4
4
0
Carcinoma
Adenosine deaminase activity in gastric cancer.
diagnostic usage
ongoing research
unassigned
3
3
0
Carcinoma
Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues.
diagnostic usage
ongoing research
unassigned
1
4
0
Carcinoma
High adenosine deaminase level in pleural effusion due to bronchoalveolar carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
3
3
1
0
Carcinoma
Adenosine deaminase activity in patients with the intestinal type of gastric carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
2
3
4
0
Carcinoma
Studies on purine enzymes in experimental colitis.
causal interaction
ongoing research
unassigned
3
2
0
Carcinoma
[Specificity of adenosine deaminase of living cancerous tissue of atypic rat epithelioma.]
ongoing research
unassigned
2
0
Carcinoma
Adenosine deaminase, xanthine oxidase, superoxide dismutase, glutathione peroxidase activities and malondialdehyde levels in the sera of patients with head and neck carcinoma.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
4
4
1
Carcinoma
Reinforcement of antitumor effect of Cordyceps sinensis by 2'-deoxycoformycin, an adenosine deaminase inhibitor.
ongoing research
therapeutic application
unassigned
3
1
0
Carcinoma
Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue.
diagnostic usage
unassigned
4
0
Carcinoma
Diagnostic significance of adenosine deaminase, uric acid and C-reactive protein levels in patients of head and neck carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
2
0
Carcinoma
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
diagnostic usage
ongoing research
unassigned
3
1
0
Carcinoma
Activities of serum Ada, GGT and alp in carcinoma breast-a case control study for diagnostic and prognostic significance.
diagnostic usage
ongoing research
unassigned
4
4
0
Carcinoma
Oxidative stress and inflammatory response biomarkers in dogs with mammary carcinoma.
diagnostic usage
ongoing research
unassigned
4
4
0
Carcinoma
Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
4
2
4
Carcinoma
Serum adenosine deaminase, catalase, and carbonic anhydrase activities in patients with renal cell carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Carcinoma
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
causal interaction
diagnostic usage
ongoing research
therapeutic application
4
4
4
3
Carcinoma
A novel diagnostic method for distinguishing parapneumonic effusion and empyema from other diseases by using the pleural lactate dehydrogenase to adenosine deaminase ratio and carcinoembryonic antigen levels.
diagnostic usage
ongoing research
unassigned
4
2
0
Carcinoma
Serum Adenosine Deaminase Levels and Human Papillomavirus as Prognostic and Predictive Factors for Laryngeal and Pharyngeal Carcinomas.
diagnostic usage
ongoing research
unassigned
4
3
0
Carcinoma
Role of downregulated ADARB1 in lung squamous cell carcinoma.
ongoing research
unassigned
4
0
Carcinoma, Bronchogenic
The association of adenosine deaminase activity with T-lymphocytes and subsets in pulmonary tuberculosis and bronchogenic carcinoma.
causal interaction
ongoing research
unassigned
1
1
0
Carcinoma, Bronchogenic
Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral blood cells of patients with neoplastic diseases. I. Bronchogenic carcinoma.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
3
4
1
Carcinoma, Bronchogenic
[Studies on the activity of adenosine deaminase in plasma in cancerous diseases with special regard to bronchial carcinoma.]
diagnostic usage
ongoing research
unassigned
1
3
0
Carcinoma, Bronchogenic
Role of biochemical tests in the diagnosis of exudative pleural effusions.
causal interaction
diagnostic usage
unassigned
3
4
0
Carcinoma, Ehrlich Tumor
Cell proliferation in the thymus of Ehrlich ascites tumor bearing mice.
ongoing research
unassigned
1
0
Carcinoma, Ehrlich Tumor
Synergistic effect of 3'-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
1
2
0
Carcinoma, Hepatocellular
[Adenosine deaminase activity in hepatomas of varying degrees of malignancy]
diagnostic usage
unassigned
3
0
Carcinoma, Hepatocellular
Adenosine deaminase and adenosine kinase in rat hepatomas and kidney tumours.
causal interaction
ongoing research
therapeutic application
unassigned
2
4
2
0
Carcinoma, Hepatocellular
[Changes in the lymphoid cells of DNA and purine nucleotide synthesis and sensitivity to glucocorticoids associated with impairment of differentiation and immune function during tumor growth in mice. Thymocytes]
causal interaction
therapeutic application
unassigned
2
1
0
Carcinoma, Hepatocellular
[Changes in DNA and purine nucleotide synthesis in lymphoid cells and sensitivity to glucocorticoids associated with the impairment of differentiation and immune function in mice during tumor growth. Spleen T- and B-lymphocytes]
causal interaction
diagnostic usage
therapeutic application
unassigned
2
1
1
0
Carcinoma, Hepatocellular
Chromosome anomalies associated with amplification of the adenosine deaminase gene (ADA) in rat hepatoma cells.
causal interaction
diagnostic usage
unassigned
2
1
0
Carcinoma, Hepatocellular
Some biochemical mechanisms underlying the impairment of T and B cell immunity in C3HA mice during hepatoma growth.
causal interaction
diagnostic usage
unassigned
3
3
0
Carcinoma, Hepatocellular
Destabilization of the adenosine deaminase gene sequences in rat-rat somatic cell hybrids.
diagnostic usage
ongoing research
unassigned
3
4
0
Carcinoma, Hepatocellular
Adenosine deaminase gene amplification in deoxycoformycin-resistant mammalian cells.
ongoing research
therapeutic application
unassigned
2
1
0
Carcinoma, Hepatocellular
Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera.
unassigned
0
Carcinoma, Hepatocellular
Biochemical approaches to enhancement of antitumor drug selectivity: selective protection of cells from 6-thioguanine and 6-mercaptopurine by adenosine.
diagnostic usage
unassigned
3
0
Carcinoma, Hepatocellular
[Changes in purine metabolism and in the immune response in the thymic and splenic lymphocytes of C3HA mice during chemical hepatocarcinogenesis]
diagnostic usage
therapeutic application
unassigned
3
1
0
Carcinoma, Hepatocellular
Increased adenosine deaminase synthesis and messenger RNA activity in deoxycoformycin-resistant cells.
diagnostic usage
ongoing research
unassigned
1
3
0
Carcinoma, Hepatocellular
Amplification of adenosine deaminase gene sequences in deoxycoformycin-resistant rat hepatoma cells.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
4
1
0
Carcinoma, Hepatocellular
Adenosine deaminase from deoxycoformycin-sensitive and -resistant rat hepatoma cells. Purification and characterization.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
1
4
1
Carcinoma, Hepatocellular
Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma.
causal interaction
ongoing research
unassigned
2
2
0
Carcinoma, Lewis Lung
[Effect of GMDP encapsulated into liposomes on metastatic spread of Lewis lung carcinoma]
ongoing research
unassigned
3
0
Carcinoma, Renal Cell
Adenosine deaminase activity in a transplantable murine renal adenocarcinoma.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
4
1
0
Carcinoma, Renal Cell
Adenosine deaminase activity in patients with renal adenocarcinoma.
diagnostic usage
ongoing research
therapeutic application
unassigned
4
4
1
0
Carcinoma, Renal Cell
Serum adenosine deaminase, catalase, and carbonic anhydrase activities in patients with renal cell carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Carcinoma, Small Cell
A novel diagnostic method for distinguishing parapneumonic effusion and empyema from other diseases by using the pleural lactate dehydrogenase to adenosine deaminase ratio and carcinoembryonic antigen levels.
diagnostic usage
ongoing research
unassigned
4
2
0
Carcinoma, Squamous Cell
Characterization of adenosine deaminase from normal human epidermis and squamous cell carcinoma of the skin.
diagnostic usage
ongoing research
unassigned
2
4
0
Carcinoma, Squamous Cell
Adenosine deaminase, 5' nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in cancerous and noncancerous human laryngeal tissues.
diagnostic usage
ongoing research
unassigned
1
4
0
Carcinoma, Squamous Cell
Adenosine deaminase in saliva as a diagnostic marker of squamous cell carcinoma of tongue.
diagnostic usage
unassigned
4
0
Carcinoma, Squamous Cell
Diagnostic significance of adenosine deaminase, uric acid and C-reactive protein levels in patients of head and neck carcinoma.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
2
0
Carcinoma, Squamous Cell
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
diagnostic usage
ongoing research
unassigned
3
1
0
Carcinoma, Squamous Cell
Adenosine Deaminase - a Novel Diagnostic and Prognostic Biomarker for Oral Squamous Cell Carcinoma.
causal interaction
diagnostic usage
ongoing research
therapeutic application
1
4
2
4
Carcinoma, Squamous Cell
ADAR1 overexpression is associated with cervical cancer progression and angiogenesis.
causal interaction
diagnostic usage
ongoing research
therapeutic application
4
4
4
3
Carcinoma, Squamous Cell
A novel diagnostic method for distinguishing parapneumonic effusion and empyema from other diseases by using the pleural lactate dehydrogenase to adenosine deaminase ratio and carcinoembryonic antigen levels.
diagnostic usage
ongoing research
unassigned
4
2
0
Carcinoma, Squamous Cell
Role of downregulated ADARB1 in lung squamous cell carcinoma.
ongoing research
unassigned
4
0
Carcinoma, Transitional Cell
Studies of lymphocyte adenosine deaminase activity in patients with renal and transitional cell carcinoma.
diagnostic usage
ongoing research
unassigned
1
2
0
Carcinoma, Transitional Cell
Adenosine deaminase activity in patients with carcinoma of the bladder.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
3
0
Cardiomegaly
[The enzymatic activity of adenosine metabolism in the rat heart. The effects of cardiac hypertrophy]
ongoing research
therapeutic application
unassigned
2
1
0
Cauda Equina Syndrome
[Cauda equina syndrome with elevated adenosine deaminase in a patient with HIV infection]
causal interaction
diagnostic usage
unassigned
3
3
0
Celiac Disease
Elevated adenosine deaminase levels in celiac disease.
causal interaction
diagnostic usage
unassigned
3
3
0
Celiac Disease
DNA damage, oxidative stress, and inflammation in children with celiac disease.
diagnostic usage
ongoing research
unassigned
3
4
0
Cerebral Infarction
Profile of tuberculous meningitis with or without HIV infection and the predicators of adverse outcome.
diagnostic usage
therapeutic application
unassigned
3
1
0
Cerebrovascular Disorders
Diagnostic value of cerebrospinal fluid adenosine deaminase determination.
diagnostic usage
unassigned
1
0
Chagas Disease
E-NTPDase and E-ADA activities are altered in lymphocytes of patients with indeterminate form of Chagas' disease.
causal interaction
ongoing research
unassigned
2
3
0
Chagas Disease
ADENOSINE DEAMINASE ACTIVITY AND SERUM C-REACTIVE PROTEIN AS PROGNOSTIC MARKERS OF CHAGAS DISEASE SEVERITY.
diagnostic usage
unassigned
4
0
Chemical and Drug Induced Liver Injury
AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis.
ongoing research
unassigned
4
0
Chickenpox
[Adenosine deaminase deficiency associated severe combined immunodeficiency with disseminated varicella infection after vaccination: a case report]
causal interaction
therapeutic application
unassigned
3
2
0
Cholecystitis, Acute
[Dynamics of the cytokines, homocysteine contents, indices of oxydative and nitrosative stress and cytopathic hypoxia in patients after cholecystectomy for acute cholecystitis. Connection with rate of postoperative purulent-inflammatory complications]
diagnostic usage
unassigned
1
0
Cholelithiasis
[Enzymatic activity of serum adenosine deaminase in different liver disorders]
diagnostic usage
unassigned
4
0
Cholera
Inhibition of lipolysis and cyclic AMP accumulation by adenosine analogues in hamster epididymal adipocytes exposed to cholera toxin.
diagnostic usage
ongoing research
therapeutic application
unassigned
1
4
1
0
Cholera
Evaluation of adenosine or related nucleosides as physiological regulators of lipolysis in adipose tissue.
therapeutic application
unassigned
1
0
Chordoma
Overexpression of adenosine deaminase acting on RNA 1 in chordoma tissues is associated with chordoma pathogenesis by reducing miR?125a and miR?10a expression.
causal interaction
diagnostic usage
ongoing research
unassigned
3
4
4
0
Choriocarcinoma
Increased expression of one of two adenosine deaminase alleles in a human choriocarcinoma cell line following selection with adenine nucleosides.
causal interaction
diagnostic usage
ongoing research
therapeutic application
4
2
3
1
coagulation factor viia deficiency
A self-controlled comparative clinical trial to explore the effectiveness of three topical hemostatic agents for stopping severe epistaxis in pediatrics with inherited coagulopathies.
diagnostic usage
therapeutic application
unassigned
4
1
0
Coccidioidomycosis
Coccidioidomycosis: ADA levels, serologic parameters, culture results, and PCR testing in pleural fluid.
diagnostic usage
unassigned
3
0
Coinfection
Serum Adenosine Deaminase (ADA) Activity: A Novel Screening Test to Differentiate HIV Monoinfection From HIV-HBV and HIV-HCV Coinfections.
diagnostic usage
ongoing research
therapeutic application
unassigned
4
1
1
0
Colitis
Blood purine and energy status in rats with colitis.
diagnostic usage
ongoing research
therapeutic application
unassigned
4
3
2
0
Colitis
Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
1
4
3
Colitis
The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors.
causal interaction
ongoing research
therapeutic application
unassigned
2
2
2
0
Colitis
Therapeutic potentials of adenosine receptors agonists and antagonists in colitis; Current status and perspectives.
causal interaction
ongoing research
therapeutic application
unassigned
2
2
2
0
Colitis, Ulcerative
Serum adenosine deaminase activity as a predictor of disease severity in ulcerative colitis.
causal interaction
diagnostic usage
unassigned
2
4
0
Colonic Neoplasms
Effects of aqueous green tea extract on activities of DNA turn-over enzymes in cancerous and non-cancerous human gastric and colon tissues.
causal interaction
ongoing research
therapeutic application
unassigned
3
4
2
0
Colonic Neoplasms
Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A(1) adenosine receptors.
ongoing research
therapeutic application
unassigned
3
1
0
Colonic Neoplasms
Genetic variability within Adenosine Deaminase gene and uterine leiomyomas.
causal interaction
unassigned
3
0
Colorectal Neoplasms
Activities of adenosine deaminase and 5'-nucleotidase in cancerous and noncancerous human colorectal tissues.
causal interaction
diagnostic usage
ongoing research
unassigned
3
1
3
0
Coma
Characteristic abnormalities in cerebrospinal fluid biochemistry in children with cerebral malaria compared to viral encephalitis.
causal interaction
diagnostic usage
ongoing research
therapeutic application
3
4
3
1
Coma
Profile of tuberculous meningitis with or without HIV infection and the predicators of adverse outcome.
diagnostic usage
therapeutic application
unassigned
3
1
0
Common Variable Immunodeficiency
Epstein-Barr virus-induced lymphoblastoid cell lines from patients with primary immunodeficiency diseases.
causal interaction
therapeutic application
unassigned
3
1
0
Common Variable Immunodeficiency
Adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency in common variable immunodeficiency.
causal interaction
unassigned
4
0
Communicable Diseases
Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status.
therapeutic application
unassigned
1
0
Congenital Abnormalities
The molecular genetics of pediatric lipid disorders: recent progress and future research directions.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
1
3
0
Congenital Abnormalities
Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes.
causal interaction
unassigned
3
0
Congenital Abnormalities
Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function.
causal interaction
unassigned
2
0
Congenital Abnormalities
[Adenosine deaminase as costimulatory molecule and marker of cellular immunity].
causal interaction
unassigned
3
0
Contracture
In vitro ischaemic preconditioning of isolated rabbit cardiomyocytes: effects of selective adenosine receptor blockade and calphostin C.
unassigned
0
Contracture
Effects of endogenous adenosine and adenosine receptor agonists on hypoxia-induced myocardial stunning in Guinea-pig atria and papillary muscles.
causal interaction
unassigned
2
0
Contracture
Adenosine reduces the reverse mode of the Na+/Ca(2+) exchanger in ferret cardiac fibres.
ongoing research
therapeutic application
unassigned
1
1
0
Coronary Artery Disease
Does adenosine deaminase play a key role in coronary artery disease.
causal interaction
therapeutic application
unassigned
3
1
0
Coronary Artery Disease
ADA*2 Allele of the Adenosine Deaminase Gene May Protect against Coronary Artery Disease.
therapeutic application
unassigned
2
0
Coronary Artery Disease
Adenosine Deaminase Genetic Polymorphism and Coronary Artery Disease.
causal interaction
diagnostic usage
ongoing research
unassigned
3
3
2
0
Coronary Artery Disease
Genetic Polymorphism of Adenosine Deaminase and Early Neonatal Events: Is There an Association with Susceptibility to Coronary Artery Disease in Adult Life?
causal interaction
unassigned
3
0
Coronary Artery Disease
The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils.
causal interaction
therapeutic application
unassigned
1
2
0
Coronary Artery Disease
Coronary artery disease: a study on the joint role of birth weight, adenosine deaminase, and gender.
causal interaction
ongoing research
therapeutic application
unassigned
3
4
1
0
Coronary Artery Disease
The interaction of ACP1, ADA1, diabetes and gender in coronary artery disease.
diagnostic usage
therapeutic application
unassigned
1
1
0
Coronary Artery Disease
Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene.
ongoing research
therapeutic application
unassigned
1
1
0
Coronary Artery Disease
Serum adenosine deaminase activity and coronary artery disease: a retrospective case-control study based on 9929 participants.
ongoing research
unassigned
2
0
Coronary Disease
Type-2 diabetes mellitus and the frequency of the G22A polymorphism of the adenosine deaminase gene in a mixed population in Brazil.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
2
1
0
Coronary Occlusion
Effect of exogenous adenosine deaminase on arrhythmias and the release of adenine nucleotide catabolites in isolated rat hearts with coronary occlusion and reperfusion.
ongoing research
therapeutic application
unassigned
2
1
0
Coronary Occlusion
Role of adenosine in coronary vasodilation during exercise.
therapeutic application
unassigned
1
0
Coronary Occlusion
Role of adenosine in coronary blood flow regulation after reductions in perfusion pressure.
therapeutic application
unassigned
1
0
Coronary Occlusion
Effect of adenosine deaminase inhibitors on myocardial reactive hyperaemia following brief coronary occlusions.
causal interaction
therapeutic application
unassigned
2
2
0
Coronary Occlusion
Role of adenosine in the maintenance of coronary vasodilation distal to a severe coronary artery stenosis. Observations in conscious domestic swine.
unassigned
0
Coronary Occlusion
Augmentation of endogenous adenosine attenuates myocardial 'stunning' independently of coronary flow or hemodynamic effects.
ongoing research
therapeutic application
unassigned
1
4
0
Coronary Occlusion
Effect of temperature on myocardial infarction in swine.
diagnostic usage
ongoing research
unassigned
2
3
0
Coronavirus Infections
Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus.
diagnostic usage
ongoing research
therapeutic application
unassigned
2
3
3
0
Cough
[Exploratory research on diagnostic essentials of pediatric tuberculous pleurisy].
diagnostic usage
ongoing research
therapeutic application
unassigned
3
1
2
0
Cough
Development of a clinical prediction rule for tuberculous meningitis in adults in Lima, Peru.
diagnostic usage
ongoing research
unassigned
2
2
0
Crohn Disease
Adaptation to past malarial endemia and susceptibility to common diseases in modern populations: a study of adenosine deaminase and MN blood group genetic polymorphisms.
causal interaction
diagnostic usage
ongoing research
therapeutic application
2
2
2
2
Crohn Disease
Adenosine deaminase activity in patients with Crohn's disease: distinction between active and nonactive disease.
causal interaction
ongoing research
unassigned
1
2
0
Crohn Disease
No Association Between Serum Adenosine Deaminase Activity and Disease Activity in Crohn's Disease.
causal interaction
diagnostic usage
unassigned
1
4
0
Crush Syndrome
Activity of enzymes of adenyline compounds metabolism during crush and decompression of muscle tissue. Part II. Adenosine deaminase activity at experimental crush syndrome.
ongoing research
unassigned
4
0
Cryopyrin-Associated Periodic Syndromes
Diagnostic utility of a targeted next-generation sequencing gene panel in the clinical suspicion of systemic autoinflammatory diseases: a multi-center study.
unassigned
0
Cystic Fibrosis
Human gene therapy for hereditary diseases: a review of trials.
causal interaction
therapeutic application
unassigned
2
2
0
Cystic Fibrosis
Gene therapy for ovarian carcinoma.
causal interaction
therapeutic application
unassigned
3
4
0
Cystic Fibrosis
Towards gene therapy for the central nervous system.
causal interaction
diagnostic usage
therapeutic application
unassigned
3
4
3
0
Cystic Fibrosis
Alveolar-like Stem Cell-derived Myb(neg) Macrophages Promote Recovery and Survival in Airway Disease.
causal interaction
unassigned
3
0