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EC Number
Disease
PubMed ID
Title of Publication
Category
Confidence Level
Aberrant Crypt Foci
Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice.
therapeutic application
2
Aberrant Crypt Foci
Short curcumin treatment modulates oxidative stress, arginase activity, aberrant crypt foci, and TGF-?1and HES-1 transcripts in 1, 2-dimethylhydrazine-colon carcinogenesis in mice.
unassigned
0
Acute Kidney Injury
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
causal interaction
1
Acute Kidney Injury
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
diagnostic usage
1
Acute Kidney Injury
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
ongoing research
1
Acute Kidney Injury
Melatonin reduces nitric oxide via increasing arginase in rhabdomyolysis-induced acute renal failure in rats.
unassigned
0
Acute Lung Injury
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
causal interaction
1
Acute Lung Injury
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
causal interaction
4
Acute Lung Injury
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
diagnostic usage
1
Acute Lung Injury
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
diagnostic usage
2
Acute Lung Injury
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
therapeutic application
1
Acute Lung Injury
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
therapeutic application
1
Acute Lung Injury
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
ongoing research
2
Acute Lung Injury
Acute Lung Injury-Induced Collagen Deposition is Associated with Elevated Asymmetric Dimethylarginine and Arginase Activity.
unassigned
0
Adenocarcinoma
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
causal interaction
2
Adenocarcinoma
Clinical significance of arginase in colorectal cancer.
causal interaction
4
Adenocarcinoma
Immunohistochemical study of arginase in cancer of the stomach.
causal interaction
2
Adenocarcinoma
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
causal interaction
2
Adenocarcinoma
Clinical significance of arginase in colorectal cancer.
diagnostic usage
4
Adenocarcinoma
Immunohistochemical study of arginase in cancer of the stomach.
diagnostic usage
4
Adenocarcinoma
Arginase isoforms in human colorectal cancer.
diagnostic usage
4
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
diagnostic usage
3
Adenocarcinoma
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
therapeutic application
3
Adenocarcinoma
Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice.
therapeutic application
3
Adenocarcinoma
Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice.
therapeutic application
1
Adenocarcinoma
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
therapeutic application
1
Adenocarcinoma
CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.
therapeutic application
1
Adenocarcinoma
Immunohistochemical study of arginase in cancer of the stomach.
therapeutic application
1
Adenocarcinoma
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
therapeutic application
1
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
therapeutic application
1
Adenocarcinoma
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
ongoing research
2
Adenocarcinoma
Arginase activity and nucleic acid content in mamary adenocarcinoma and normal homologous tissue of C3H mice.
ongoing research
4
Adenocarcinoma
Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice.
ongoing research
4
Adenocarcinoma
Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice.
ongoing research
4
Adenocarcinoma
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
ongoing research
4
Adenocarcinoma
CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.
ongoing research
1
Adenocarcinoma
Clinical significance of arginase in colorectal cancer.
ongoing research
3
Adenocarcinoma
Immunohistochemical study of arginase in cancer of the stomach.
ongoing research
4
Adenocarcinoma
Arginase isoforms in human colorectal cancer.
ongoing research
4
Adenocarcinoma
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
ongoing research
2
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
ongoing research
2
Adenocarcinoma
Arginase activity and nucleic acid content in mamary adenocarcinoma and normal homologous tissue of C3H mice.
unassigned
0
Adenocarcinoma
Inhibitory effects of arginase on mammary adenocarcinoma transplants in strain "A" mice.
unassigned
0
Adenocarcinoma
Effects of adrenocorticotropic hormone (ACTH), cortisone, and arginase on growth of transplanted mammary adenocarcinoma in C3H mice.
unassigned
0
Adenocarcinoma
Participation of non-neuronal muscarinic receptors in the effect of carbachol with paclitaxel on human breast adenocarcinoma cells. Roles of nitric oxide synthase and arginase.
unassigned
0
Adenocarcinoma
CD13(hi) Neutrophil-like myeloid-derived suppressor cells exert immune suppression through Arginase 1 expression in pancreatic ductal adenocarcinoma.
unassigned
0
Adenocarcinoma
Arginase isoforms in human colorectal cancer.
unassigned
0
Adenocarcinoma
Early detection of pancreatic cancers in liquid biopsies by ultrasensitive fluorescence nanobiosensors.
unassigned
0
Adenocarcinoma
Nitric oxide synthase, arginase and cyclooxygenase are involved in muscarinic receptor activation in different murine mammary adenocarcinoma cell lines.
unassigned
0
Adenocarcinoma
Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines.
unassigned
0
Adenocarcinoma
Clinical significance of arginase in colorectal cancer.
unassigned
0
Adenocarcinoma of Lung
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
causal interaction
4
Adenocarcinoma of Lung
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
diagnostic usage
3
Adenocarcinoma of Lung
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.
therapeutic application
4
Adenocarcinoma of Lung
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
therapeutic application
4
Adenocarcinoma of Lung
Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity.
ongoing research
4
Adenocarcinoma of Lung
Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models.
unassigned
0
Adrenoleukodystrophy
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
causal interaction
1
Adrenoleukodystrophy
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
unassigned
0
Airway Obstruction
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
causal interaction
4
Airway Obstruction
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
causal interaction
4
Airway Obstruction
Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).
causal interaction
2
Airway Obstruction
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
therapeutic application
4
Airway Obstruction
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
therapeutic application
2
Airway Obstruction
Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).
therapeutic application
1
Airway Obstruction
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
ongoing research
2
Airway Obstruction
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
unassigned
0
Airway Obstruction
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
unassigned
0
Airway Obstruction
Asymmetric Dimethylarginine in Chronic Obstructive Pulmonary Disease (ADMA in COPD).
unassigned
0
Albuminuria
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.
ongoing research
4
Albuminuria
Diabetic nephropathy is resistant to oral L-arginine or L-citrulline supplementation.
unassigned
0
Alopecia
[Clinical and biochemical alterations in rats treated with high doses of vitamin A]
causal interaction
3
Alopecia
[Clinical and biochemical alterations in rats treated with high doses of vitamin A]
unassigned
0
Alphavirus Infections
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
causal interaction
1
Alphavirus Infections
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
therapeutic application
2
Alphavirus Infections
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
ongoing research
2
Alphavirus Infections
Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus.
unassigned
0
Alzheimer Disease
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
causal interaction
2
Alzheimer Disease
Bioinformatics methods in drug repurposing for Alzheimer's disease.
causal interaction
1
Alzheimer Disease
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
diagnostic usage
4
Alzheimer Disease
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
ongoing research
4
Alzheimer Disease
L-Norvaline, a new therapeutic agent against Alzheimer's disease.
unassigned
0
Alzheimer Disease
Bioinformatics methods in drug repurposing for Alzheimer's disease.
unassigned
0
Alzheimer Disease
The Role of Arginine-Nitric Oxide Pathway in Patients with Alzheimer Disease.
unassigned
0
Amebiasis
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
causal interaction
1
Amebiasis
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
therapeutic application
4
Amebiasis
Structural insights into Entamoeba histolytica arginase and structure-based identification of novel non-amino acid based inhibitors as potential antiamoebic molecules.
unassigned
0
amino-acid n-acetyltransferase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
causal interaction
4
amino-acid n-acetyltransferase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
causal interaction
3
amino-acid n-acetyltransferase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
unassigned
0
amino-acid n-acetyltransferase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
unassigned
0
Amyotrophic Lateral Sclerosis
Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.
diagnostic usage
4
Amyotrophic Lateral Sclerosis
[Study of cerebrospinal fluid arginase activity in the diagnosis of amyotrophic lateral sclerosis]
diagnostic usage
4
Amyotrophic Lateral Sclerosis
Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.
ongoing research
4
Amyotrophic Lateral Sclerosis
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.
ongoing research
2
Amyotrophic Lateral Sclerosis
Alterations of arginase activity in scrapie-infected mice and in amyotrophic lateral sclerosis.
unassigned
0
Amyotrophic Lateral Sclerosis
[Study of cerebrospinal fluid arginase activity in the diagnosis of amyotrophic lateral sclerosis]
unassigned
0
Amyotrophic Lateral Sclerosis
Microglia and motor neurons during disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis: changes in arginase1 and inducible nitric oxide synthase.
unassigned
0
Anaplasmosis
Enzymes of oxidant defence system of leucocytes and erythrocytes in bovine anaplasmosis.
unassigned
0
Anemia
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
causal interaction
3
Anemia
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
diagnostic usage
3
Anemia
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
diagnostic usage
4
Anemia
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
therapeutic application
1
Anemia
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
therapeutic application
1
Anemia
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
ongoing research
3
Anemia
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
ongoing research
4
Anemia
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
unassigned
0
Anemia
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
unassigned
0
Anemia, Hemolytic
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
causal interaction
3
Anemia, Hemolytic
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
diagnostic usage
4
Anemia, Hemolytic
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
therapeutic application
1
Anemia, Hemolytic
[Arginase activity in plasma and erythrocytes in children with hematologic diseases]
ongoing research
3
Anemia, Hypochromic
Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.
therapeutic application
1
Anemia, Hypochromic
Mode of Action of the Toxin from Pseudomonas phaseolicola: I. Toxin Specificity, Chlorosis, and Ornithine Accumulation.
unassigned
0
Anemia, Pernicious
The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major.
ongoing research
1
Anemia, Pernicious
The arginase activity of erythrocytes and leukocytes with particular reference to pernicious anemia and thalassemia major.
unassigned
0
Anemia, Sickle Cell
Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.
causal interaction
3
Anemia, Sickle Cell
Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease.
causal interaction
1
Anemia, Sickle Cell
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
causal interaction
4
Anemia, Sickle Cell
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
causal interaction
4
Anemia, Sickle Cell
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.
causal interaction
3
Anemia, Sickle Cell
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
causal interaction
4
Anemia, Sickle Cell
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
causal interaction
2
Anemia, Sickle Cell
Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway.
causal interaction
1
Anemia, Sickle Cell
Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.
diagnostic usage
2
Anemia, Sickle Cell
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
diagnostic usage
3
Anemia, Sickle Cell
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
diagnostic usage
4
Anemia, Sickle Cell
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
diagnostic usage
4
Anemia, Sickle Cell
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
diagnostic usage
1
Anemia, Sickle Cell
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
diagnostic usage
2
Anemia, Sickle Cell
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
therapeutic application
1
Anemia, Sickle Cell
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
therapeutic application
2
Anemia, Sickle Cell
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.
therapeutic application
4
Anemia, Sickle Cell
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
therapeutic application
4
Anemia, Sickle Cell
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
therapeutic application
1
Anemia, Sickle Cell
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
therapeutic application
4
Anemia, Sickle Cell
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
therapeutic application
1
Anemia, Sickle Cell
Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.
therapeutic application
1
Anemia, Sickle Cell
Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease.
ongoing research
2
Anemia, Sickle Cell
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease.
ongoing research
3
Anemia, Sickle Cell
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
ongoing research
4
Anemia, Sickle Cell
Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.
ongoing research
3
Anemia, Sickle Cell
Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules (sICAM-1 and sVCAM-1) and hemolysis markers among steady-state sickle cell anemia patients.
unassigned
0
Anemia, Sickle Cell
Hemolysis-associated pulmonary hypertension in thalassemia.
unassigned
0
Anemia, Sickle Cell
Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease.
unassigned
0
Anemia, Sickle Cell
Pattern of hemolysis parameters and association with fetal hemoglobin in sickle cell anemia patients in steady state.
unassigned
0
Anemia, Sickle Cell
Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice.
unassigned
0
Anemia, Sickle Cell
Influence of ?S-Globin Haplotypes and Hydroxyurea on Arginase I Levels in Sickle Cell Disease.
unassigned
0
Anemia, Sickle Cell
Amplified expression profiling of platelet transcriptome reveals changes in arginine metabolic pathways in patients with sickle cell disease.
unassigned
0
Anemia, Sickle Cell
In vitro evidence of the inhibitory capacity of chloroquine on arginase activity in sickle erythrocytes.
unassigned
0
Anemia, Sickle Cell
Growth inhibitory and differentiation effects of chloroquine and its analogue on human leukemic cells potentiate fetal hemoglobin production by targeting the polyamine pathway.
unassigned
0
Anemia, Sickle Cell
Modulation of erythrocyte arginase activity in sickle cell disease patients during hydroxyurea therapy.
unassigned
0
Anemia, Sickle Cell
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.
unassigned
0
Anemia, Sickle Cell
Cysteine-iron promotes arginase activity by driving the Fenton reaction.
unassigned
0
Anemia, Sideroblastic
A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity.
causal interaction
1
Anemia, Sideroblastic
A case of sideroblastic anaemia associated with marked elevation of erythrocytic arginase activity.
unassigned
0
Angina Pectoris
Early diagnosis of myocardial infarction by arginase activity determination.
causal interaction
3
Angina Pectoris
Early diagnosis of myocardial infarction by arginase activity determination.
diagnostic usage
4
Angina Pectoris
Early diagnosis of myocardial infarction by arginase activity determination.
therapeutic application
2
Angina Pectoris
Early diagnosis of myocardial infarction by arginase activity determination.
unassigned
0
Aortic Aneurysm, Abdominal
Transforming growth factor ? neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta.
ongoing research
1
Aortic Aneurysm, Abdominal
Transforming growth factor ? neutralization finely tunes macrophage phenotype in elastase-induced abdominal aortic aneurysm and is associated with an increase of arginase 1 expression in the aorta.
unassigned
0
arginase deficiency
Hyperargininemia with arginase deficiency.
causal interaction
3
arginase deficiency
Arginase deficiency in multiple tissues in argininemia.
causal interaction
1
arginase deficiency
Arginase deficiency.
causal interaction
3
arginase deficiency
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
causal interaction
4
arginase deficiency
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
causal interaction
4
arginase deficiency
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
causal interaction
4
arginase deficiency
Molecular genetic study of human arginase deficiency.
causal interaction
4
arginase deficiency
Mouse model for human arginase deficiency.
causal interaction
3
arginase deficiency
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
causal interaction
4
arginase deficiency
A new case of arginase deficiency in a Spanish male.
causal interaction
3
arginase deficiency
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
causal interaction
4
arginase deficiency
Prenatal diagnosis for arginase deficiency: a case study.
causal interaction
3
arginase deficiency
Liver fibrosis in arginase deficiency.
causal interaction
4
arginase deficiency
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.
causal interaction
3
arginase deficiency
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
causal interaction
4
arginase deficiency
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
causal interaction
4
arginase deficiency
Hyperargininemia due to liver arginase deficiency.
causal interaction
4
arginase deficiency
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
causal interaction
2
arginase deficiency
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
causal interaction
4
arginase deficiency
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
causal interaction
1
arginase deficiency
Urinary pyrimidine excretion in arginase deficiency.
causal interaction
3
arginase deficiency
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
causal interaction
1
arginase deficiency
"Cerebral Palsy" in a Patient With Arginase Deficiency.
causal interaction
1
arginase deficiency
Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.
causal interaction
3
arginase deficiency
Arginase deficiency presenting as cerebral palsy.
causal interaction
1
arginase deficiency
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
causal interaction
4
arginase deficiency
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
causal interaction
4
arginase deficiency
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
causal interaction
3
arginase deficiency
[Arginase deficiency]
causal interaction
3
arginase deficiency
Anesthesia in a patient with arginase deficiency: implications and management.
causal interaction
1
arginase deficiency
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
causal interaction
4
arginase deficiency
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
causal interaction
3
arginase deficiency
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
causal interaction
3
arginase deficiency
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
causal interaction
4
arginase deficiency
Arginase I deficiency: Severe infantile presentation with hyperammonemia: More common than reported?
causal interaction
3
arginase deficiency
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
causal interaction
3
arginase deficiency
Newborn screening for hyperargininemia due to arginase 1 deficiency.
causal interaction
3
arginase deficiency
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency.
causal interaction
4
arginase deficiency
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.
causal interaction
3
arginase deficiency
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
causal interaction
3
arginase deficiency
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.
causal interaction
4
arginase deficiency
A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening.
causal interaction
3
arginase deficiency
Hyperargininemia.
causal interaction
4
arginase deficiency
[The dibasic amino acid metabolic disorders]
causal interaction
1
arginase deficiency
Creatine metabolism and the urea cycle.
causal interaction
4
arginase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
causal interaction
4
arginase deficiency
[Late diagnosis of congenital argininemia during administration of sodium valproate]
causal interaction
2
arginase deficiency
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
causal interaction
3
arginase deficiency
Hyperargininemia, epilepsy and the metabolism of guanidino compounds.
causal interaction
3
arginase deficiency
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
causal interaction
1
arginase deficiency
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
causal interaction
2
arginase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
causal interaction
3
arginase deficiency
A new French-Canadian family affected by hyperargininaemia.
causal interaction
3
arginase deficiency
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
causal interaction
3
arginase deficiency
A successful trial of enzyme replacement therapy in a case of argininemia.
causal interaction
1
arginase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
causal interaction
3
arginase deficiency
Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity.
causal interaction
1
arginase deficiency
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
causal interaction
1
arginase deficiency
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
causal interaction
3
arginase deficiency
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
causal interaction
2
arginase deficiency
Orotic acid excretion and arginine metabolism.
causal interaction
3
arginase deficiency
Biomarkers identified in inborn errors for lysine, arginine, and ornithine.
causal interaction
3
arginase deficiency
Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders.
causal interaction
4
arginase deficiency
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
causal interaction
1
arginase deficiency
Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.
causal interaction
4
arginase deficiency
Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice.
causal interaction
1
arginase deficiency
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
causal interaction
4
arginase deficiency
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
causal interaction
4
arginase deficiency
Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism.
causal interaction
4
arginase deficiency
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
causal interaction
3
arginase deficiency
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
causal interaction
3
arginase deficiency
Arginase deficiency in multiple tissues in argininemia.
diagnostic usage
1
arginase deficiency
A simple screening test for arginase deficiency (hyperargininemia).
diagnostic usage
4
arginase deficiency
A simple spot-test for the detection of erythrocyte arginase deficiency.
diagnostic usage
3
arginase deficiency
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
diagnostic usage
4
arginase deficiency
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
diagnostic usage
1
arginase deficiency
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
diagnostic usage
4
arginase deficiency
Molecular genetic study of human arginase deficiency.
diagnostic usage
4
arginase deficiency
A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations.
diagnostic usage
2
arginase deficiency
Mouse model for human arginase deficiency.
diagnostic usage
4
arginase deficiency
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
diagnostic usage
1
arginase deficiency
Prenatal diagnosis for arginase deficiency: a case study.
diagnostic usage
4
arginase deficiency
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
diagnostic usage
4
arginase deficiency
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
diagnostic usage
4
arginase deficiency
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
diagnostic usage
1
arginase deficiency
Urinary pyrimidine excretion in arginase deficiency.
diagnostic usage
4
arginase deficiency
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
diagnostic usage
3
arginase deficiency
"Cerebral Palsy" in a Patient With Arginase Deficiency.
diagnostic usage
4
arginase deficiency
Arginase deficiency in two brothers.
diagnostic usage
1
arginase deficiency
Arginase deficiency presenting as cerebral palsy.
diagnostic usage
4
arginase deficiency
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
diagnostic usage
1
arginase deficiency
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
diagnostic usage
2
arginase deficiency
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency.
diagnostic usage
2
arginase deficiency
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
diagnostic usage
4
arginase deficiency
The nutritional management of urea cycle disorders.
diagnostic usage
4
arginase deficiency
Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.
diagnostic usage
3
arginase deficiency
[Late diagnosis of congenital argininemia during administration of sodium valproate]
diagnostic usage
4
arginase deficiency
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
diagnostic usage
1
arginase deficiency
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
diagnostic usage
1
arginase deficiency
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
diagnostic usage
1
arginase deficiency
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.
diagnostic usage
4
arginase deficiency
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
diagnostic usage
3
arginase deficiency
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
diagnostic usage
2
arginase deficiency
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
diagnostic usage
2
arginase deficiency
Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity.
diagnostic usage
1
arginase deficiency
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
diagnostic usage
4
arginase deficiency
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
diagnostic usage
2
arginase deficiency
Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders.
diagnostic usage
2
arginase deficiency
Unsuccessful trial of gene replacement in arginase deficiency.
therapeutic application
1
arginase deficiency
Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector.
therapeutic application
1
arginase deficiency
Hyperargininemia with arginase deficiency.
therapeutic application
3
arginase deficiency
Arginase deficiency.
therapeutic application
1
arginase deficiency
A simple screening test for arginase deficiency (hyperargininemia).
therapeutic application
1
arginase deficiency
A simple spot-test for the detection of erythrocyte arginase deficiency.
therapeutic application
1
arginase deficiency
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
therapeutic application
4
arginase deficiency
Arginase deficiency presenting with cerebral oedema and failure to thrive.
therapeutic application
1
arginase deficiency
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
therapeutic application
1
arginase deficiency
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
therapeutic application
1
arginase deficiency
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
therapeutic application
2
arginase deficiency
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
therapeutic application
1
arginase deficiency
Prenatal diagnosis for arginase deficiency: a case study.
therapeutic application
3
arginase deficiency
Arginase deficiency and phenylketonuria.
therapeutic application
1
arginase deficiency
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.
therapeutic application
1
arginase deficiency
Impaired neurotransmitter amine metabolism in arginase deficiency.
therapeutic application
1
arginase deficiency
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
therapeutic application
1
arginase deficiency
[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]
therapeutic application
1
arginase deficiency
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
therapeutic application
1
arginase deficiency
Hyperargininemia due to liver arginase deficiency.
therapeutic application
1
arginase deficiency
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
therapeutic application
1
arginase deficiency
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
therapeutic application
1
arginase deficiency
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
therapeutic application
2
arginase deficiency
Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet.
therapeutic application
4
arginase deficiency
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
therapeutic application
4
arginase deficiency
"Cerebral Palsy" in a Patient With Arginase Deficiency.
therapeutic application
1
arginase deficiency
Arginase deficiency presenting with convulsions.
therapeutic application
1
arginase deficiency
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
therapeutic application
3
arginase deficiency
Arginase deficiency in two brothers.
therapeutic application
2
arginase deficiency
Arginase deficiency presenting as cerebral palsy.
therapeutic application
2
arginase deficiency
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
therapeutic application
4
arginase deficiency
[Proposal for a diet treatment in arginase deficiency]
therapeutic application
4
arginase deficiency
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
therapeutic application
1
arginase deficiency
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
therapeutic application
4
arginase deficiency
[Arginase deficiency]
therapeutic application
1
arginase deficiency
Adult-onset arginase deficiency.
therapeutic application
1
arginase deficiency
Anesthetic management of a patient with arginase deficiency undergoing liver transplantation.
therapeutic application
1
arginase deficiency
Anesthesia in a patient with arginase deficiency: implications and management.
therapeutic application
2
arginase deficiency
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
therapeutic application
1
arginase deficiency
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
therapeutic application
2
arginase deficiency
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
therapeutic application
2
arginase deficiency
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
therapeutic application
1
arginase deficiency
Newborn screening for hyperargininemia due to arginase 1 deficiency.
therapeutic application
1
arginase deficiency
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
therapeutic application
2
arginase deficiency
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.
therapeutic application
1
arginase deficiency
Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.
therapeutic application
1
arginase deficiency
[Late diagnosis of congenital argininemia during administration of sodium valproate]
therapeutic application
2
arginase deficiency
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
therapeutic application
3
arginase deficiency
Arginase-2 mediates renal ischemia-reperfusion injury.
therapeutic application
1
arginase deficiency
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.
therapeutic application
1
arginase deficiency
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
therapeutic application
4
arginase deficiency
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
therapeutic application
4
arginase deficiency
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
therapeutic application
1
arginase deficiency
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
therapeutic application
1
arginase deficiency
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.
therapeutic application
2
arginase deficiency
Orotic acid excretion and arginine metabolism.
therapeutic application
1
arginase deficiency
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
therapeutic application
4
arginase deficiency
Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI.
therapeutic application
2
arginase deficiency
Unsuccessful trial of gene replacement in arginase deficiency.
ongoing research
2
arginase deficiency
Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector.
ongoing research
2
arginase deficiency
Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings]
ongoing research
3
arginase deficiency
Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
ongoing research
4
arginase deficiency
Diffusion tensor imaging in arginase deficiency reveals damage to corticospinal tracts.
ongoing research
2
arginase deficiency
Molecular genetic study of human arginase deficiency.
ongoing research
4
arginase deficiency
Mouse model for human arginase deficiency.
ongoing research
4
arginase deficiency
A new case of arginase deficiency in a Spanish male.
ongoing research
2
arginase deficiency
Liver fibrosis in arginase deficiency.
ongoing research
1
arginase deficiency
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
ongoing research
1
arginase deficiency
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
ongoing research
4
arginase deficiency
Prenatal diagnosis for arginase deficiency by second-trimester fetal erythrocyte arginase assay and first-trimester ARG1 mutation analysis.
ongoing research
1
arginase deficiency
Arginase deficiency with new phenotype and a novel mutation: contemporary summary.
ongoing research
2
arginase deficiency
Recurrent unexplained hyperammonemia in an adolescent with arginase deficiency.
ongoing research
3
arginase deficiency
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
ongoing research
4
arginase deficiency
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
ongoing research
4
arginase deficiency
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
ongoing research
1
arginase deficiency
The human arginases and arginase deficiency.
ongoing research
3
arginase deficiency
Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse.
ongoing research
2
arginase deficiency
A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening.
ongoing research
1
arginase deficiency
Hyperargininemia, epilepsy and the metabolism of guanidino compounds.
ongoing research
1
arginase deficiency
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
ongoing research
3
arginase deficiency
Arginase-2 mediates renal ischemia-reperfusion injury.
ongoing research
3
arginase deficiency
Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts.
ongoing research
3
arginase deficiency
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
ongoing research
4
arginase deficiency
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
ongoing research
2
arginase deficiency
Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity.
ongoing research
1
arginase deficiency
Loss of function mutations in conserved regions of the human arginase I gene.
ongoing research
1
arginase deficiency
Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice.
ongoing research
2
arginase deficiency
Unsuccessful trial of gene replacement in arginase deficiency.
unassigned
0
arginase deficiency
Short-term Correction of Arginase Deficiency in a Neonatal Murine Model With a Helper-dependent Adenoviral Vector.
unassigned
0
arginase deficiency
A simple screening test for arginase deficiency (hyperargininemia).
unassigned
0
arginase deficiency
A simple spot-test for the detection of erythrocyte arginase deficiency.
unassigned
0
arginase deficiency
Influence of arginase deficiency on amino acid concentrations in sheep erythrocytes with a normal and with a defective transport system for amino acids [proceedings]
unassigned
0
arginase deficiency
Arginase deficiency presenting with cerebral oedema and failure to thrive.
unassigned
0
arginase deficiency
A long-term survival case of arginase deficiency with severe multicystic white matter and compound mutations.
unassigned
0
arginase deficiency
Late onset arginase deficiency presenting with encephalopathy and midbrain hyperintensity.
unassigned
0
arginase deficiency
Arginase deficiency with lethal neonatal expression: evidence for the glutamine hypothesis of cerebral edema.
unassigned
0
arginase deficiency
Arginase deficiency and phenylketonuria.
unassigned
0
arginase deficiency
Impaired neurotransmitter amine metabolism in arginase deficiency.
unassigned
0
arginase deficiency
Arginase deficiency in Macaca fascicularis. I. Arginase activity and arginine concentration in erythrocytes and liver.
unassigned
0
arginase deficiency
[Hyperargininemia wityh arginase deficiency. A new familial metabolic disease. I. Clinical studies]
unassigned
0
arginase deficiency
[Hyperargininemia with arginase deficiency. A new familial metabolic disease. II. Biochemical studies.]
unassigned
0
arginase deficiency
Treatment of hyperargininaemia due to arginase deficiency with a chemically defined diet.
unassigned
0
arginase deficiency
Properties of fetal and adult red blood cell arginase: a possible prenatal diagnostic test for arginase deficiency.
unassigned
0
arginase deficiency
Arginase deficiency presenting with convulsions.
unassigned
0
arginase deficiency
A patient with arginase deficiency and episodic hyperammonemia successfully treated with menses cessation.
unassigned
0
arginase deficiency
Arginase deficiency in two brothers.
unassigned
0
arginase deficiency
[Proposal for a diet treatment in arginase deficiency]
unassigned
0
arginase deficiency
The human arginases and arginase deficiency.
unassigned
0
arginase deficiency
Adult-onset arginase deficiency.
unassigned
0
arginase deficiency
Anesthetic management of a patient with arginase deficiency undergoing liver transplantation.
unassigned
0
arginase deficiency
Excretion of guanidino-derivates in urine of hyperargininemic patients.
unassigned
0
arginase deficiency
[Seven patients of argininemia with spastic tetraplegia as the first and major symptom and prenatal diagnosis of two fetuses with high risk].
unassigned
0
arginase deficiency
The nutritional management of urea cycle disorders.
unassigned
0
arginase deficiency
Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.
unassigned
0
arginase deficiency
Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.
unassigned
0
arginase deficiency
Pteridines and mono-amines: relevance to neurological damage.
unassigned
0
arginase deficiency
Arginase-2 mediates renal ischemia-reperfusion injury.
unassigned
0
arginase deficiency
Comparison of arginase activity in red blood cells of lower mammals, primates, and man: evolution to high activity in primates.
unassigned
0
arginase deficiency
A simple quantitative micromethod of arginase assay in blood spots dried on filter paper.
unassigned
0
arginase deficiency
Isoenzyme pattern and immunological properties of arginase in normal and hyperargininemia fibroblasts.
unassigned
0
arginase deficiency
Hyperargininemia: the rat as a model for the human disease and the comparative response to enzyme replacement therapy with free arginase and arginase-loaded erythrocytes in vivo.
unassigned
0
arginase deficiency
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl.
unassigned
0
arginase deficiency
Polyamine dependence of Chinese hamster ovary cells in serum-free culture is due to deficient arginase activity.
unassigned
0
arginase deficiency
Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.
unassigned
0
arginase deficiency
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine.
unassigned
0
arginase deficiency
Loss of function mutations in conserved regions of the human arginase I gene.
unassigned
0
arginase deficiency
Delivery of cytosolic liver arginase into the mitochondrial matrix space: a possible novel site for gene replacement therapy.
unassigned
0
arginase deficiency
Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI.
unassigned
0
arginase deficiency
AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse.
unassigned
0
arginase deficiency
Hyperargininemia with arginase deficiency.
unassigned
0
arginase deficiency
Arginase deficiency.
unassigned
0
arginase deficiency
Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy.
unassigned
0
arginase deficiency
A new case of arginase deficiency in a Spanish male.
unassigned
0
arginase deficiency
Liver fibrosis in arginase deficiency.
unassigned
0
arginase deficiency
Arginase deficiency in a 12-year-old boy with mild impairment of intellectual function.
unassigned
0
arginase deficiency
Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.
unassigned
0
arginase deficiency
Hyperargininemia due to liver arginase deficiency.
unassigned
0
arginase deficiency
Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency.
unassigned
0
arginase deficiency
Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.
unassigned
0
arginase deficiency
Arginase deficiency manifesting delayed clinical sequelae and induction of a kidney arginase isozyme.
unassigned
0
arginase deficiency
Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.
unassigned
0
arginase deficiency
Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
unassigned
0
arginase deficiency
[Arginase deficiency]
unassigned
0
arginase deficiency
Anesthesia in a patient with arginase deficiency: implications and management.
unassigned
0
arginase deficiency
Amino acids in CSF and plasma in hyperammonaemic coma due to arginase1 deficiency.
unassigned
0
arginase deficiency
Hyperargininemia due to arginase I deficiency: the original patients and their natural history, and a review of the literature.
unassigned
0
arginase deficiency
Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.
unassigned
0
arginase deficiency
Arginase I deficiency: Severe infantile presentation with hyperammonemia: More common than reported?
unassigned
0
arginase deficiency
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
unassigned
0
arginase deficiency
Newborn screening for hyperargininemia due to arginase 1 deficiency.
unassigned
0
arginase deficiency
Ornithine transcarbamylase and arginase I deficiency are responsible for diminished urea cycle function in the human hepatoblastoma cell line HepG2.
unassigned
0
arginase deficiency
Inducible arginase 1 deficiency in mice leads to hyperargininemia and altered amino acid metabolism.
unassigned
0
arginase deficiency
A new metabolic disorder in human cationic amino acid transporter-2 that mimics arginase 1 deficiency in newborn screening.
unassigned
0
arginase deficiency
Hyperargininemia.
unassigned
0
arginase deficiency
[The dibasic amino acid metabolic disorders]
unassigned
0
arginase deficiency
Creatine metabolism and the urea cycle.
unassigned
0
arginase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
unassigned
0
arginase deficiency
Hyperargininemia, epilepsy and the metabolism of guanidino compounds.
unassigned
0
arginase deficiency
Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells.
unassigned
0
arginase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
unassigned
0
arginase deficiency
A new French-Canadian family affected by hyperargininaemia.
unassigned
0
arginase deficiency
Long-term Survival of the Juvenile Lethal Arginase-deficient Mouse With AAV Gene Therapy.
unassigned
0
arginase deficiency
A successful trial of enzyme replacement therapy in a case of argininemia.
unassigned
0
arginase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
unassigned
0
arginase deficiency
Five novel mutations in ARG1 gene in Chinese patients of argininemia.
unassigned
0
arginase deficiency
Orotic acid excretion and arginine metabolism.
unassigned
0
arginase deficiency
Biomarkers identified in inborn errors for lysine, arginine, and ornithine.
unassigned
0
arginase deficiency
[A case of complicated form of hereditary spastic paraplegia associated with hypoplasia of the corpus callosum and cataracta]
unassigned
0
arginase deficiency
Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.
unassigned
0
arginase deficiency
Myocyte-mediated Arginase Expression Controls Hyperargininemia but not Hyperammonemia in Arginase-deficient Mice.
unassigned
0
arginase deficiency
Minimal ureagenesis is necessary for survival in the murine model of hyperargininemia treated by AAV-based gene therapy.
unassigned
0
arginase deficiency
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
unassigned
0
arginase deficiency
Clinical consequences of urea cycle enzyme deficiencies and potential links to arginine and nitric oxide metabolism.
unassigned
0
arginase deficiency
Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity.
unassigned
0
arginase deficiency
Early liver transplantation in neonatal-onset and moderate urea cycle disorders may lead to normal neurodevelopment.
unassigned
0
arginase deficiency
Arginase deficiency in multiple tissues in argininemia.
unassigned
0
arginase deficiency
A novel mutation in ARG1 gene is responsible for arginase deficiency in an Asian family.
unassigned
0
arginase deficiency
Molecular genetic study of human arginase deficiency.
unassigned
0
arginase deficiency
Mouse model for human arginase deficiency.
unassigned
0
arginase deficiency
Urinary pyrimidine excretion in arginase deficiency.
unassigned
0
arginase deficiency
Clinical, biochemical, and molecular spectrum of hyperargininemia due to arginase I deficiency.
unassigned
0
arginase deficiency
Efficacy and safety of i.v. sodium benzoate in urea cycle disorders: a multicentre retrospective study.
unassigned
0
arginase deficiency
Different missense mutations in PDR1 and PDR3 genes from clotrimazole-resistant sake yeast are responsible for pleiotropic drug resistance and improved fermentative activity.
unassigned
0
arginase deficiency
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
unassigned
0
arginase deficiency
Untargeted metabolomic profiling reveals multiple pathway perturbations and new clinical biomarkers in urea cycle disorders.
unassigned
0
arginase deficiency
[Arginase deficiency, congenital hypothyroidism and hepatic fibrosis]
unassigned
0
arginase deficiency
Prenatal diagnosis for arginase deficiency: a case study.
unassigned
0
arginase deficiency
"Cerebral Palsy" in a Patient With Arginase Deficiency.
unassigned
0
arginase deficiency
Arginase deficiency presenting as cerebral palsy.
unassigned
0
arginase deficiency
Treatment of arginase deficiency revisited: guanidinoacetate as a therapeutic target and biomarker for therapeutic monitoring.
unassigned
0
arginase deficiency
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
unassigned
0
arginase deficiency
[Late diagnosis of congenital argininemia during administration of sodium valproate]
unassigned
0
arginase deficiency
Neonatal cholestasis: an uncommon presentation of hyperargininemia.
unassigned
0
arginase deficiency
Fluorometric micromethod for determination of arginase activity in dried blood spots on filter paper.
unassigned
0
argininosuccinate lyase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
causal interaction
4
argininosuccinate lyase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
causal interaction
3
argininosuccinate lyase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
causal interaction
3
argininosuccinate lyase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
diagnostic usage
3
argininosuccinate lyase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
therapeutic application
1
argininosuccinate lyase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
unassigned
0
argininosuccinate lyase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
unassigned
0
argininosuccinate lyase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
unassigned
0
argininosuccinate lyase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
unassigned
0
argininosuccinate synthase deficiency
Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country.
causal interaction
1
argininosuccinate synthase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
causal interaction
4
argininosuccinate synthase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
causal interaction
3
argininosuccinate synthase deficiency
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
causal interaction
3
argininosuccinate synthase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
causal interaction
3
argininosuccinate synthase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
diagnostic usage
3
argininosuccinate synthase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
therapeutic application
1
argininosuccinate synthase deficiency
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
unassigned
0
argininosuccinate synthase deficiency
Clinical and biochemical characteristics of patients with urea cycle disorders in a developing country.
unassigned
0
argininosuccinate synthase deficiency
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
unassigned
0
argininosuccinate synthase deficiency
Genetic approach to prenatal diagnosis in urea cycle defects.
unassigned
0
argininosuccinate synthase deficiency
Liver transplantation may prevent neurodevelopmental deterioration in high-risk patients with urea cycle disorders.
unassigned
0
argininosuccinate synthase deficiency
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
unassigned
0
Argininosuccinic Aciduria
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
causal interaction
3
Argininosuccinic Aciduria
Genetic approach to prenatal diagnosis in urea cycle defects.
causal interaction
3
Argininosuccinic Aciduria
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
causal interaction
4
Argininosuccinic Aciduria
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
causal interaction
3
Argininosuccinic Aciduria
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
diagnostic usage
2
Argininosuccinic Aciduria
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
diagnostic usage
3
Argininosuccinic Aciduria
ARGININOSUCCINIC ACIDURIA. ARGININOSUCCINASE AND ARGINASE IN HUMAN BLOOD CELLS.
therapeutic application
1
Argininosuccinic Aciduria
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
therapeutic application
1
Argininosuccinic Aciduria
ARGININOSUCCINIC ACIDURIA. ARGININOSUCCINASE AND ARGINASE IN HUMAN BLOOD CELLS.
ongoing research
4
Argininosuccinic Aciduria
ARGININOSUCCINIC ACIDURIA. ARGININOSUCCINASE AND ARGINASE IN HUMAN BLOOD CELLS.
unassigned
0
Argininosuccinic Aciduria
Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate.
unassigned
0
Argininosuccinic Aciduria
Genetic approach to prenatal diagnosis in urea cycle defects.
unassigned
0
Argininosuccinic Aciduria
Improving long term outcomes in urea cycle disorders-report from the Urea Cycle Disorders Consortium.
unassigned
0
Argininosuccinic Aciduria
Biochemical markers and neuropsychological functioning in distal urea cycle disorders.
unassigned
0
Argininosuccinic Aciduria
Prenatal diagnosis of the urea cycle diseases: a survey of the European cases.
unassigned
0
Arrhythmias, Cardiac
Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart.
therapeutic application
1
Arrhythmias, Cardiac
Arginase induction and activation during ischemia and reperfusion and functional consequences for the heart.
unassigned
0
Arthritis
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
causal interaction
2
Arthritis
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis.
causal interaction
1
Arthritis
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
causal interaction
1
Arthritis
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
diagnostic usage
4
Arthritis
Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway.
diagnostic usage
2
Arthritis
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis.
therapeutic application
4
Arthritis
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
therapeutic application
4
Arthritis
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
therapeutic application
1
Arthritis
Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.
therapeutic application
1
Arthritis
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
ongoing research
4
Arthritis
Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway.
ongoing research
4
Arthritis
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis.
ongoing research
2
Arthritis
Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: A possible anti-arthritic mechanism of eugenol.
ongoing research
2
Arthritis
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
ongoing research
3
Arthritis
Endothelial dysfunction in rat adjuvant-induced arthritis: Up-regulation of the vascular arginase pathway.
unassigned
0
Arthritis
Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: A possible anti-arthritic mechanism of eugenol.
unassigned
0
Arthritis
Diclofenac but not celecoxib improves endothelial function in rheumatoid arthritis: A study in adjuvant-induced arthritis.
unassigned
0
Arthritis
Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis.
unassigned
0
Arthritis
Treatment with the arginase inhibitor Nw-hydroxy-nor-L-arginine restores endothelial function in rat adjuvant-induced arthritis.
unassigned
0
Arthritis
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
unassigned
0
Arthritis
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
unassigned
0
Arthritis, Reactive
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
causal interaction
2
Arthritis, Reactive
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
diagnostic usage
4
Arthritis, Reactive
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
therapeutic application
2
Arthritis, Reactive
[SPECIES COMPOSITION OF INFECTIOUS FACTORS THAT CAUSE THE REACTIVE ARTHRITIS DEVELOPMENT AND THEIR EFFECT ON ARGINASE-NO-SYNTHASE REGULATORY SYSTEM OF PERIPHERAL BLOOD LYMPHOCYTES].
unassigned
0
Arthritis, Rheumatoid
Arginase levels are increased in patients with rheumatoid arthritis.
causal interaction
4
Arthritis, Rheumatoid
Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis.
causal interaction
2
Arthritis, Rheumatoid
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
causal interaction
3
Arthritis, Rheumatoid
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
causal interaction
1
Arthritis, Rheumatoid
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
causal interaction
2
Arthritis, Rheumatoid
Arginase levels are increased in patients with rheumatoid arthritis.
diagnostic usage
4
Arthritis, Rheumatoid
Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis.
diagnostic usage
4
Arthritis, Rheumatoid
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
diagnostic usage
4
Arthritis, Rheumatoid
Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity.
diagnostic usage
3
Arthritis, Rheumatoid
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
diagnostic usage
4
Arthritis, Rheumatoid
Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity.
therapeutic application
1
Arthritis, Rheumatoid
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
therapeutic application
4
Arthritis, Rheumatoid
Arginase levels are increased in patients with rheumatoid arthritis.
ongoing research
2
Arthritis, Rheumatoid
Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis.
ongoing research
3
Arthritis, Rheumatoid
Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity.
ongoing research
4
Arthritis, Rheumatoid
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
ongoing research
4
Arthritis, Rheumatoid
Changes in the pattern of cytokine production from peripheral blood mononuclear cells in patients with rheumatoid arthritis treated with infliximab and their relation to plasma arginase activity.
unassigned
0
Arthritis, Rheumatoid
Vascular Arginase Is a Relevant Target to Improve Cerebrovascular Endothelial Dysfunction in Rheumatoid Arthritis: Evidence from the Model of Adjuvant-Induced Arthritis.
unassigned
0
Arthritis, Rheumatoid
Arginase levels are increased in patients with rheumatoid arthritis.
unassigned
0
Arthritis, Rheumatoid
Relationship between synovial fluid and plasma manganese, arginase, and nitric oxide in patients with rheumatoid arthritis.
unassigned
0
Arthritis, Rheumatoid
Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.
unassigned
0
Arthritis, Rheumatoid
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide.
unassigned
0
Asthma
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
causal interaction
1
Asthma
Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.
causal interaction
4
Asthma
Decreased arginine bioavailability and increased serum arginase activity in asthma.
causal interaction
4
Asthma
Relationship among manganese, arginase, and nitric oxide in childhood asthma.
causal interaction
4
Asthma
Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
causal interaction
3
Asthma
The therapeutic potential of drugs targeting the arginase pathway in asthma.
causal interaction
4
Asthma
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
causal interaction
3
Asthma
Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
causal interaction
2
Asthma
Roles of arginase variants, atopy, and ozone in childhood asthma.
causal interaction
1
Asthma
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
causal interaction
2
Asthma
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.
causal interaction
4
Asthma
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
causal interaction
4
Asthma
High Serum Arginase I Levels in Asthma: its Correlation with High-Sensitivity C-Reactive Protein.
causal interaction
4
Asthma
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
causal interaction
2
Asthma
Increased arginase activity contributes to airway remodelling in chronic allergic asthma.
causal interaction
4
Asthma
Arginase and arginine dysregulation in asthma.
causal interaction
4
Asthma
Role of arginase in asthma: potential clinical applications.
causal interaction
3
Asthma
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.
causal interaction
3
Asthma
Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma.
causal interaction
4
Asthma
Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
causal interaction
3
Asthma
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
causal interaction
3
Asthma
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.
causal interaction
4
Asthma
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis.
causal interaction
1
Asthma
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
causal interaction
4
Asthma
Arginase: marker, effector, or candidate gene for asthma?
causal interaction
4
Asthma
Enhancer-mediated control of macrophage-specific arginase I expression.
causal interaction
3
Asthma
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
causal interaction
1
Asthma
Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients.
causal interaction
4
Asthma
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.
causal interaction
4
Asthma
New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy.
causal interaction
1
Asthma
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
causal interaction
4
Asthma
Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.
causal interaction
4
Asthma
[Arginine metabolism in bronchial asthma]
causal interaction
4
Asthma
Arginine homeostasis in allergic asthma.
causal interaction
4
Asthma
Arginase and pulmonary diseases.
causal interaction
4
Asthma
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.
causal interaction
4
Asthma
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
causal interaction
4
Asthma
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
causal interaction
4
Asthma
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
causal interaction
1
Asthma
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
causal interaction
2
Asthma
Probing the specificity determinants of amino acid recognition by arginase.
causal interaction
4
Asthma
Asthma management: reinventing the wheel in sickle cell disease.
causal interaction
3
Asthma
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
causal interaction
4
Asthma
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
causal interaction
3
Asthma
Increased expression of arginase I and II in allergic nasal mucosa.
causal interaction
4
Asthma
Asthma in sickle cell disease.
causal interaction
2
Asthma
TGF-{beta}2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells.
causal interaction
1
Asthma
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
causal interaction
3
Asthma
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
causal interaction
1
Asthma
Pollutant particles induce arginase II in human bronchial epithelial cells.
causal interaction
4
Asthma
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
causal interaction
3
Asthma
Nitric oxide in asthma physiopathology.
causal interaction
2
Asthma
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
causal interaction
2
Asthma
Small-molecule arginase inhibitors.
causal interaction
3
Asthma
Airway arginase expression and N?-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains.
causal interaction
4
Asthma
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
causal interaction
3
Asthma
Effects of inhaled L-arginine administration in a murine model of acute asthma.
causal interaction
3
Asthma
The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression.
causal interaction
4
Asthma
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
causal interaction
4
Asthma
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
causal interaction
3
Asthma
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
causal interaction
3
Asthma
l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.
causal interaction
4
Asthma
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
causal interaction
1
Asthma
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
causal interaction
4
Asthma
Arginine metabolic endotypes related to asthma severity.
causal interaction
1
Asthma
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
causal interaction
3
Asthma
Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma.
causal interaction
4
Asthma
[Sputum arginase activity in bronchial asthma]
diagnostic usage
3
Asthma
Decreased arginine bioavailability and increased serum arginase activity in asthma.
diagnostic usage
4
Asthma
Relationship among manganese, arginase, and nitric oxide in childhood asthma.
diagnostic usage
4
Asthma
Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
diagnostic usage
1
Asthma
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
diagnostic usage
1
Asthma
Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
diagnostic usage
1
Asthma
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.
diagnostic usage
4
Asthma
Arginase and pulmonary diseases.
diagnostic usage
4
Asthma
Alterations of the arginine metabolome in asthma.
diagnostic usage
4
Asthma
Asthma management: reinventing the wheel in sickle cell disease.
diagnostic usage
3
Asthma
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
diagnostic usage
1
Asthma
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
diagnostic usage
1
Asthma
l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.
diagnostic usage
1
Asthma
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children.
diagnostic usage
3
Asthma
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
diagnostic usage
1
Asthma
Arginine metabolic endotypes related to asthma severity.
diagnostic usage
4
Asthma
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
therapeutic application
1
Asthma
[Sputum arginase activity in bronchial asthma]
therapeutic application
2
Asthma
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
therapeutic application
1
Asthma
Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.
therapeutic application
4
Asthma
cNOS-iNOS paradigm and arginase in asthma.
therapeutic application
1
Asthma
Decreased arginine bioavailability and increased serum arginase activity in asthma.
therapeutic application
1
Asthma
Relationship among manganese, arginase, and nitric oxide in childhood asthma.
therapeutic application
1
Asthma
Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
therapeutic application
2
Asthma
The therapeutic potential of drugs targeting the arginase pathway in asthma.
therapeutic application
4
Asthma
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
therapeutic application
1
Asthma
Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
therapeutic application
1
Asthma
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
therapeutic application
4
Asthma
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
therapeutic application
1
Asthma
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.
therapeutic application
4
Asthma
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
therapeutic application
2
Asthma
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
therapeutic application
4
Asthma
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
therapeutic application
1
Asthma
Increased arginase activity contributes to airway remodelling in chronic allergic asthma.
therapeutic application
1
Asthma
Arginase and arginine dysregulation in asthma.
therapeutic application
3
Asthma
Role of arginase in asthma: potential clinical applications.
therapeutic application
4
Asthma
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.
therapeutic application
4
Asthma
Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma.
therapeutic application
4
Asthma
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
therapeutic application
3
Asthma
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.
therapeutic application
1
Asthma
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis.
therapeutic application
4
Asthma
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
therapeutic application
1
Asthma
Enhancer-mediated control of macrophage-specific arginase I expression.
therapeutic application
1
Asthma
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
therapeutic application
2
Asthma
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.
therapeutic application
4
Asthma
New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy.
therapeutic application
1
Asthma
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
therapeutic application
2
Asthma
Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.
therapeutic application
1
Asthma
[Arginine metabolism in bronchial asthma]
therapeutic application
1
Asthma
Arginine homeostasis in allergic asthma.
therapeutic application
4
Asthma
Arginase and pulmonary diseases.
therapeutic application
2
Asthma
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
therapeutic application
4
Asthma
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
therapeutic application
3
Asthma
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
therapeutic application
1
Asthma
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
therapeutic application
2
Asthma
Probing the specificity determinants of amino acid recognition by arginase.
therapeutic application
4
Asthma
Asthma management: reinventing the wheel in sickle cell disease.
therapeutic application
1
Asthma
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
therapeutic application
4
Asthma
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
therapeutic application
3
Asthma
Increased expression of arginase I and II in allergic nasal mucosa.
therapeutic application
1
Asthma
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
therapeutic application
1
Asthma
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
therapeutic application
1
Asthma
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
therapeutic application
2
Asthma
Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model.
therapeutic application
3
Asthma
Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I.
therapeutic application
2
Asthma
Nitric oxide in asthma physiopathology.
therapeutic application
3
Asthma
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
therapeutic application
1
Asthma
Arginine and asthma.
therapeutic application
1
Asthma
Small-molecule arginase inhibitors.
therapeutic application
4
Asthma
Airway arginase expression and N?-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains.
therapeutic application
1
Asthma
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
therapeutic application
3
Asthma
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
therapeutic application
1
Asthma
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
therapeutic application
4
Asthma
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
therapeutic application
4
Asthma
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
therapeutic application
4
Asthma
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children.
therapeutic application
2
Asthma
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
therapeutic application
2
Asthma
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
therapeutic application
2
Asthma
Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma.
therapeutic application
1
Asthma
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
ongoing research
2
Asthma
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
ongoing research
2
Asthma
Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.
ongoing research
2
Asthma
Decreased arginine bioavailability and increased serum arginase activity in asthma.
ongoing research
3
Asthma
Relationship among manganese, arginase, and nitric oxide in childhood asthma.
ongoing research
4
Asthma
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
ongoing research
2
Asthma
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
ongoing research
2
Asthma
Functionally Important Role for Arginase 1 in the Airways Hyperresponsiveness of Asthma.
ongoing research
1
Asthma
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
ongoing research
2
Asthma
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
ongoing research
1
Asthma
Increased arginase activity contributes to airway remodelling in chronic allergic asthma.
ongoing research
4
Asthma
Arginase and arginine dysregulation in asthma.
ongoing research
2
Asthma
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.
ongoing research
1
Asthma
Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma.
ongoing research
4
Asthma
Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
ongoing research
3
Asthma
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
ongoing research
4
Asthma
Association of increased risk of asthma with elevated arginase & interleukin-13 levels in serum & rs2781666 G/T genotype of arginase I.
ongoing research
4
Asthma
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
ongoing research
4
Asthma
Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts.
ongoing research
4
Asthma
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
ongoing research
1
Asthma
Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.
ongoing research
2
Asthma
[Arginine metabolism in bronchial asthma]
ongoing research
2
Asthma
Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?
ongoing research
2
Asthma
Arginase and pulmonary diseases.
ongoing research
4
Asthma
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.
ongoing research
2
Asthma
Alterations of the arginine metabolome in asthma.
ongoing research
2
Asthma
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
ongoing research
4
Asthma
L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction.
ongoing research
2
Asthma
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
ongoing research
4
Asthma
Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation.
ongoing research
2
Asthma
Regulation of nitric oxide generation by up-regulated arginase I in rat spinal cord injury.
ongoing research
4
Asthma
Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model.
ongoing research
3
Asthma
Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma.
ongoing research
1
Asthma
Nitric oxide in asthma physiopathology.
ongoing research
1
Asthma
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
ongoing research
4
Asthma
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
ongoing research
2
Asthma
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
ongoing research
4
Asthma
Arginine metabolic endotypes related to asthma severity.
ongoing research
3
Asthma
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
ongoing research
3
Asthma
[Sputum arginase activity in bronchial asthma]
unassigned
0
Asthma
Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.
unassigned
0
Asthma
cNOS-iNOS paradigm and arginase in asthma.
unassigned
0
Asthma
Transiently, paralleled upregulation of arginase and nitric oxide synthase and the effect of both enzymes on the pathology of asthma.
unassigned
0
Asthma
Mepacrine inhibits subepithelial fibrosis by reducing the expression of arginase and TGF-beta1 in an extended subacute mouse model of allergic asthma.
unassigned
0
Asthma
Simvastatin inhibits goblet cell hyperplasia and lung arginase in a mouse model of allergic asthma: a novel treatment for airway remodeling?
unassigned
0
Asthma
Glucocorticoid inhibition of interleukin-4 (IL-4) and interleukin-13 (IL-13) induced up-regulation of arginase in rat airway fibroblasts.
unassigned
0
Asthma
Mouse models of asthma: can they give us mechanistic insights into the role of nitric oxide?
unassigned
0
Asthma
Alterations of the arginine metabolome in asthma.
unassigned
0
Asthma
Arginase enzymes in isolated airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin.
unassigned
0
Asthma
L-Arginine deficiency causes airway hyperresponsiveness after the late asthmatic reaction.
unassigned
0
Asthma
Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC/Nga mouse model.
unassigned
0
Asthma
Mechanisms of occupational asthma: Not all allergens are equal.
unassigned
0
Asthma
Modeling gas phase nitric oxide release in lung epithelial cells.
unassigned
0
Asthma
Nitric oxide and related enzymes in asthma: relation to severity, enzyme function and inflammation.
unassigned
0
Asthma
Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model.
unassigned
0
Asthma
Impact of substrate protonation and tautomerization States on interactions with the active site of arginase I.
unassigned
0
Asthma
Increased Ornithine-Derived Polyamines cause Airways Hyperresponsiveness in a Mouse Model of Asthma.
unassigned
0
Asthma
Arginine and asthma.
unassigned
0
Asthma
Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity.
unassigned
0
Asthma
Short-term exposure to PM2.5 and vanadium and changes in asthma gene DNA methylation and lung function decrements among urban children.
unassigned
0
Asthma
Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization.
unassigned
0
Asthma
[Carbamoyl ornithine transferase, arginase and cobalt-activated acylase in patients during asthma attacks or patients with respiratory failure]
unassigned
0
Asthma
Arginase and asthma: novel insights into nitric oxide homeostasis and airway hyperresponsiveness.
unassigned
0
Asthma
Arginase activity differs with allergen in the effector phase of ovalbumin- versus trimellitic anhydride-induced asthma.
unassigned
0
Asthma
The therapeutic potential of drugs targeting the arginase pathway in asthma.
unassigned
0
Asthma
Genetic polymorphisms in arginase I and II and childhood asthma and atopy.
unassigned
0
Asthma
Roles of arginase variants, atopy, and ozone in childhood asthma.
unassigned
0
Asthma
Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives.
unassigned
0
Asthma
Arginase 1 and arginase 2 variations associate with asthma, asthma severity and beta2 agonist and steroid response.
unassigned
0
Asthma
High Serum Arginase I Levels in Asthma: its Correlation with High-Sensitivity C-Reactive Protein.
unassigned
0
Asthma
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma.
unassigned
0
Asthma
Increased arginase activity contributes to airway remodelling in chronic allergic asthma.
unassigned
0
Asthma
Arginase and arginine dysregulation in asthma.
unassigned
0
Asthma
Role of arginase in asthma: potential clinical applications.
unassigned
0
Asthma
Competitive metabolism of L-arginine: arginase as a therapeutic target in asthma.
unassigned
0
Asthma
Beneficial effects of arginase inhibition and inhaled l-arginine administration on airway histology in a murine model of chronic asthma.
unassigned
0
Asthma
Arginase 1 deletion in myeloid cells affects the inflammatory response in allergic asthma, but not lung mechanics, in female mice.
unassigned
0
Asthma
Recent Patents in Allergy/Immunology: Use of arginase inhibitors in the treatment of asthma and allergic rhinitis.
unassigned
0
Asthma
Increased arginase activity underlies allergen-induced deficiency of cNOS-derived nitric oxide and airway hyperresponsiveness.
unassigned
0
Asthma
Arginase: marker, effector, or candidate gene for asthma?
unassigned
0
Asthma
Enhancer-mediated control of macrophage-specific arginase I expression.
unassigned
0
Asthma
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors.
unassigned
0
Asthma
Evaluation of oxidative-antioxidative status and the L-arginine-nitric oxide pathway in asthmatic patients.
unassigned
0
Asthma
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages.
unassigned
0
Asthma
New Strategies for the Treatment of Pulmonary Hypertension in Sickle Cell Disease : The Rationale for Arginine Therapy.
unassigned
0
Asthma
Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness.
unassigned
0
Asthma
Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I.
unassigned
0
Asthma
[Arginine metabolism in bronchial asthma]
unassigned
0
Asthma
Arginine homeostasis in allergic asthma.
unassigned
0
Asthma
Arginases I and II in lungs of ovalbumin-sensitized mice exposed to ovalbumin: sources and consequences.
unassigned
0
Asthma
Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation.
unassigned
0
Asthma
Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice.
unassigned
0
Asthma
Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration.
unassigned
0
Asthma
Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders.
unassigned
0
Asthma
Probing the specificity determinants of amino acid recognition by arginase.
unassigned
0
Asthma
Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice.
unassigned
0
Asthma
2-Aminoimidazole Amino Acids as Inhibitors of the Binuclear Manganese Metalloenzyme Human Arginase I.
unassigned
0
Asthma
Increased expression of arginase I and II in allergic nasal mucosa.
unassigned
0
Asthma
Asthma in sickle cell disease.
unassigned
0
Asthma
TGF-{beta}2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells.
unassigned
0
Asthma
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
unassigned
0
Asthma
Resistin-Like Molecule Alpha Regulates IL-13-Induced Chemokine Production but not Allergen-Induced Airway Responses.
unassigned
0
Asthma
Pollutant particles induce arginase II in human bronchial epithelial cells.
unassigned
0
Asthma
Nitric oxide in asthma physiopathology.
unassigned
0
Asthma
Ablation of Arg1 in hematopoietic cells improves respiratory function of lung parenchyma, but not that of larger airways or inflammation in asthmatic mice.
unassigned
0
Asthma
Small-molecule arginase inhibitors.
unassigned
0
Asthma
Airway arginase expression and N?-hydroxy-nor-arginine effect on methacholine-induced bronchoconstriction differentiate Lewis and Fischer rat strains.
unassigned
0
Asthma
Arginase inhibition prevents inflammation and remodeling in a Guinea pig model of chronic obstructive pulmonary disease.
unassigned
0
Asthma
Effects of inhaled L-arginine administration in a murine model of acute asthma.
unassigned
0
Asthma
The effects of WW2/WW3 domains of Smurf2 molecule on TGF-? signaling and arginase I gene expression.
unassigned
0
Asthma
Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection.
unassigned
0
Asthma
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
unassigned
0
Asthma
Increased mitochondrial arginine metabolism supports bioenergetics in asthma.
unassigned
0
Asthma
Pharmacokinetics and Pharmacodynamics of Promising Arginase Inhibitors.
unassigned
0
Asthma
Targeting arginase and nitric oxide metabolism in chronic airway diseases and their co-morbidities.
unassigned
0
Asthma
Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma.
unassigned
0
Asthma
Relationship between serum arginase I and l-arginine or exhaled nitric oxide in asthma.
unassigned
0
Asthma
l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma.
unassigned
0
Asthma
Arginine metabolic endotypes related to asthma severity.
unassigned
0
Asthma
Arginase strongly impairs neuronal nitric oxide-mediated airway smooth muscle relaxation in allergic asthma.
unassigned
0
Asthma
Asthma management: reinventing the wheel in sickle cell disease.
unassigned
0
Asthma
Plasma arginine metabolites reflect airway dysfunction in a murine model of allergic airway inflammation.
unassigned
0
Atherosclerosis
Identification of macrophage arginase I as a new candidate gene of atherosclerosis resistance.
causal interaction
3
Atherosclerosis
Endothelial arginase: a new target in atherosclerosis.
causal interaction
4
Atherosclerosis
Endothelial arginase II: a novel target for the treatment of atherosclerosis.
causal interaction
4
Atherosclerosis
Endothelial arginase II and atherosclerosis.
causal interaction
4
Atherosclerosis
Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice.
causal interaction
3
Atherosclerosis
Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II.
causal interaction
4
Atherosclerosis
Hematopoietic arginase 1 deficiency results in decreased leukocytosis and increased foam cell formation but does not affect atherosclerosis.
causal interaction
3
Atherosclerosis
Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction.
causal interaction
4
Atherosclerosis
Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism.
causal interaction
4
Atherosclerosis
Oxidized low-density lipoprotein-dependent endothelial arginase II activation contributes to impaired nitric oxide signaling.
causal interaction
4
Atherosclerosis
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.
causal interaction
3
Atherosclerosis
Probing the specificity determinants of amino acid recognition by arginase.
causal interaction
4
Atherosclerosis
Regulation of arginase pathway in response to wall shear stress.
causal interaction
3
Atherosclerosis
Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity.
causal interaction
4
Atherosclerosis
Arginase type I as a marker of coronary heart disease in hemodialysis patients.
causal interaction
3
Atherosclerosis
Arginase activities and global arginine bioavailability in wild-type and ApoE-deficient mice: responses to high fat and high cholesterol diets.
causal interaction
2
Atherosclerosis
Binding of ?,?-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design.
causal interaction
3
Atherosclerosis
LXR{alpha} Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8.
causal interaction
4
Atherosclerosis
Arginase Inhibition by Ethylacetate Extract of Caesalpinia sappan Lignum Contributes to Activation of Endothelial Nitric Oxide Synthase.
causal interaction
3
Atherosclerosis
[Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin].
causal interaction
4
Atherosclerosis
Increase of arginase activity in old apolipoprotein-E deficient mice under Western diet associated with changes in neurovascular unit.
causal interaction
2
Atherosclerosis
Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?
causal interaction
4
Atherosclerosis
Arginase II inhibitory activity of flavonoid compounds from Scutellaria indica.
causal interaction
4
Atherosclerosis
Role of arginase in vessel wall remodeling.
causal interaction
3
Atherosclerosis
Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction.
causal interaction
3
Atherosclerosis
Arginase as a target for treatment of myocardial ischemia-reperfusion injury.
causal interaction
4
Atherosclerosis
Transcriptional regulation of endothelial arginase 2 by histone deacetylase 2.
causal interaction
4
Atherosclerosis
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.
causal interaction
2
Atherosclerosis
The Promise of Plant-Derived Substances as Inhibitors of Arginase.
causal interaction
3
Atherosclerosis
Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis.
causal interaction
3
Atherosclerosis
Early obesity leads to increases in hepatic arginase I and related systemic changes in nitric oxide and L-arginine metabolism in mice.
causal interaction
3
Atherosclerosis
Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance.
causal interaction
1
Atherosclerosis
Arginase II Contributes to the Ca2+/CaMKII/eNOS Axis by Regulating Ca2+ Concentration Between the Cytosol and Mitochondria in a p32-Dependent Manner.
causal interaction
3
Atherosclerosis
Arginase II: Atherogenesis Beyond Enzyme Activity.
diagnostic usage
1
Atherosclerosis
Poly(ADP-ribose) polymerase 1 deficiency increases nitric oxide production and attenuates aortic atherogenesis through downregulation of arginase II.
diagnostic usage
2
Atherosclerosis
Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima media thickness.
diagnostic usage
2
Show all pathways known for 3.5.3.1Display the word mapDisplay the reaction diagram