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EC Number IC50 Value IC50 Value Maximum Inhibitor Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000001 - roflumilast isozymes PDE4A, PDE4B, and PDE4D 690858
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000002 - PF-04957325 PDE8B, pH and temperature not specified in the publication 716280
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000003 - cis-(+)-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C 711443
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000004 - cis-2-[(E)-4-(1H-imidazol-1-yl)but-2-enyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C 711443
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000004 - L-826,141 isozymes PDE4B and PDE4D 690858
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000006 - roflumilast isozyme PDE4C 690858
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000007 - cis-2-[4-[(1H-imidazol-1-yl)methyl]benzyl]-4-(3,4-dimethoxyphenyl)-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C 711443
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000007 - PF-04957325 PDE8A, pH and temperature not specified in the publication 716280
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000009 - cis-4-(3,4-dimethoxyphenyl)-2-[4-(morpholinomethyl)benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C 711443
Display the word mapDisplay the reaction diagram Show all sequences 3.1.4.530.0000009 - cis-4-(3,4-dimethoxyphenyl)-2-[4-[(4-oxopiperidin-1-yl)-methyl]benzyl]-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one in Tris-HCl (pH 7.6), 100 mM NaCl, 150 mM MgCl2, and 0.5% (w/v) polyethylene glycol 6000, at 30°C 711443
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