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EC Number	IC50 Value	IC50 Value Maximum	Inhibitor	Commentary	Reference
2.7.4.22	0.01	-	UTP	at 0.05 mM UMP, UMP protects for inhibition by Mg2+ free UTP	674896
2.7.4.22	0.0156	-	N4,6-diphenylpyrimidine-2,4-diamine	pH 7.5, 22°C	737591
2.7.4.22	0.02	-	5-iodo-UTP	wild type enzyme, at pH 7.4 and 30°C	723289
2.7.4.22	0.025	-	N4-ethyl-N4,6-diphenylpyrimidine-2,4-diamine	pH 7.5, 22°C	737591
2.7.4.22	0.1	-	N4-(3-methylphenyl)-6-phenylpyrimidine-2,4-diamine	above, pH 7.5, 22°C	737591
2.7.4.22	0.1	-	N4-(4-methoxyphenyl)-6-phenylpyrimidine-2,4-diamine	above, pH 7.5, 22°C	737591
2.7.4.22	0.1	-	N4-(4-methylphenyl)-6-phenylpyrimidine-2,4-diamine	above, pH 7.5, 22°C	737591
2.7.4.22	0.1	-	UTP	wild type enzyme, at pH 7.4 and 30°C	723289
2.7.4.22	0.13	-	UTP	at 0.2 mM UMP, UMP protects for inhibition by Mg2+ free UTP	674896
2.7.4.22	0.24	-	dUTP	wild type enzyme, at pH 7.4 and 30°C	723289

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Release 2023.1 (January 2023)