EC Number   |
IC50 Value |
IC50 Value Maximum |
Inhibitor |
Reference |
|---|
    2.3.1.21 | 0.000015 |
- |
etomoxiryl-CoA |
IC50: 0.000015 mM in muscle |
672147 |
| 2.3.1.21 | 0.00003 |
- |
malonyl-CoA |
- |
702111 |
| 2.3.1.21 | 0.00004 |
- |
C75-CoA |
IC50: 0.00004 mM in muscle |
672147 |
| 2.3.1.21 | 0.00007 |
- |
malonyl-CoA |
Glu3, Leu23, and Ser24 in M-CPTI are important for malonyl-CoA inhibition and binding but not for calalysis. IC50: 0.00007 mM for wild-type enzyme, 0.01 mM for mutant enzyme E3A, 0.00015 for mutant enzyme H5A, 0.01 mM for mutant enzyme E3A/V19A/L23A/S24A, |
657652 |
| 2.3.1.21 | 0.00007 |
- |
malonyl-CoA |
mitochondrial isolate from liver, high polyunsaturated fat diet |
703294 |
| 2.3.1.21 | 0.000079 |
- |
malonyl-CoA |
CPT I, liver |
685368 |
| 2.3.1.21 | 0.000096 |
- |
malonyl-CoA |
wild-type protein, 1 mM carnitine, mitochondrial preparation |
703641 |
| 2.3.1.21 | 0.00011 |
- |
malonyl-CoA |
mitochondrial isolate from liver, high saturated fat diet |
703294 |
| 2.3.1.21 | 0.000117 |
- |
malonyl-CoA |
wild-type protein, 0.683 mM carnitine, mitochondrial preparation |
703641 |
| 2.3.1.21 | 0.00012 |
- |
malonyl-CoA |
mitochondrial isolate from liver, control diet |
703294 |
