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Results 1 - 7 of 7
EC Number Crystallization (Commentary) Reference
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2all dyneins share a conserved motor domain. The core of the dynein motor domain consists of six tandem AAA+ ATPase domains. The first AAA+ domain (AAA1) is the primary site of ATP hydrolysis, whereas the other five domains (AAA2-6) have regulatory or structural functions. The dynein linker domain acts as a relatively rigid lever that amplifies small conformational changes in the AAA+ domains upon ATP hydrolysis 711714
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2crystal structure analysis 735286
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2hanging-drop method, 1.7 A resolution, dynein light chain TcTex-1 669342
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2hanging-drop vapor diffusion method, dynein light chain Dnlc2A 667449
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2microtubule-binding domain 701228
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2resolution of 6 A of a functional dimer of two ca. 300 kDa motor domains of yeast cytoplasmic dynein, which are dimerized by glutathione S-transferase GST. The structure reveals an unusual asymmetric arrangement of ATPase domains and an unexpected interaction between two coiled coils the create a base for the microtubule binding domain 713512
Display the word mapDisplay the reaction diagram Show all sequences 5.6.1.2the active sites for microtubule binding and ATP hydrolysis communicate via conformational changes transduced through a ca. 10 nm length antiparallel coilded-coil stalk, which connects the binding domain to the roughly 300 kDa motor core. A balancing of opposing conformations in the stalk and microtubule binding domain (MTBD) enables modest ling-range interactions arising from ATP-binding in the motor core to induce a relaxation of the MTBD into the stable low affinity state 712426
Results 1 - 7 of 7