EC Number   |
|---|
    4.1.1.48 | - |
| 4.1.1.48 | 2.0 A structure |
| 4.1.1.48 | contains 17 strong salt bridges |
| 4.1.1.48 | crystal packing seems to be influenced by ionic strength of the solvent |
| 4.1.1.48 | in complex with substrate 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate, with a substrate analogue, and with product indole-3-glycerol phosphate |
| 4.1.1.48 | molecular dynamics simulations of wild-type at 25°C in the apo form and in the presence of the substrate |
| 4.1.1.48 | mutagenesis data and crystal structure analysis of IGPS from Sulfolobus solfataricus allows for the formulation of a plausible chemical mechanism of the reaction |
| 4.1.1.48 | N-terminal deletion mutant lacking 26 amino acids, structure of core is unchanged compared to wild-type |
| 4.1.1.48 | vapour diffusion method in hanging drops, the 2.0 A crystal structure is determined and compared with the known 2.0 A structure of the IGPS domain of the bifunctional enzyme from Escherichia coli. Both enzymes have only 30% sequence identity, but share high structural similarity |
