  3.5.1.131 | structures of apo AtzE and AtzE bound with the suicide inhibitor phenyl phosphorodiamidate.The AtzE enzyme complex consists of two independent molecules in the asymmetric unit. AtzE forms an alpha2beta2 heterotetramer with 68-amino acid-long protein AtzG. AtzG is essential for the production of soluble, active AtzE. 1-Carboxybiuret binds via hydrogen-bonding interactions. The terminal carboxylate of the substrate binds to Tyr-125, Asn-172, and Gln-402, the main chain carbonyl of Gly-126 binds the terminal adjacent amines, and the main chain NH of Gln-402 binds the carbonyl between those amines |
