EC Number   |
|---|
   2.3.1.81 | in complex with inhibitor N-(3-methoxyphenyl)-N-methyl-2,3-dioxo-1,2,3,4-tetrahydro-6-quinoxalinesulfonamide. Inhibitor binds Eis in the AG-binding pocket held by a conformationally malleable region of Eis (residues 28-37) bearing key hydrophobic residues |
| 2.3.1.81 | in the apo form, in binary drug (sisomicin, neomycin, and paromomycin) and coenzyme A complexes, and in the ternary neomycin-CoASH complex |
| 2.3.1.81 | structures of apo-enzyme and in complex with acetyl-CoA |
| 2.3.1.81 | X-ray structure of a recombinant enzyme, expressed in its selenomethionine substituted form, cocrystallization with 5 mM CoA at 4°C and pH: 7.8, crystal cryoprotection achieved with 17% glycerol and 8% 2R,3R-butanediol, active center found by X-ray analysis and model building |
