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EC Number	Crystallization (Commentary)
2.3.1.305	structures of free LpxA and its complexes with its product UDP-3-N-(R-3-hydroxylauroyl)-GlcNAc3N and with its substrate R-3-hydroxylauroyl-methylphosphopantetheine. The selectivity of LiLpxA for UDPGlcNAc3N may be explained by the orientation of the backbone carbonyl group of Q68, which differs by about 82° from the corresponding Q73 carbonyl group in Escherichia coli LpxA. The R-3-hydroxylauroyl selectivity of LpxA is explained by the position of the K171 side chain, which limits the length of the acyl-chain-binding groove

EC Number

Crystallization (Commentary)

2.3.1.305

structures of free LpxA and its complexes with its product UDP-3-N-(R-3-hydroxylauroyl)-GlcNAc3N and with its substrate R-3-hydroxylauroyl-methylphosphopantetheine. The selectivity of LiLpxA for UDPGlcNAc3N may be explained by the orientation of the backbone carbonyl group of Q68, which differs by about 82° from the corresponding Q73 carbonyl group in Escherichia coli LpxA. The R-3-hydroxylauroyl selectivity of LpxA is explained by the position of the K171 side chain, which limits the length of the acyl-chain-binding groove

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Release 2023.1 (January 2023)