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EC Number Crystallization (Commentary)
Display the reaction diagram Show all sequences 1.14.11.73structures of N-terminally truncated (aa 153-416 and aa 183-416) constructs and in complex with substrate RPS6. The JMJD5 active site contains a metal centre, which is octahedrally coordinated by an HXD..H motif, the 2-oxoglutarate oxalyl group and a water molecule, which is likely replaced by a dioxygen during catalysis
Display the reaction diagram Show all sequences 1.14.11.73the complex structures of JMJD5 and arginine derivatives reveals a Tudor domain-like binding pocket to accommodate the methylated sidechain of arginine, but not lysine
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