EC Number   |
Cofactor |
Reference |
|---|
   3.4.21.6 | 1,2-dicaproyl-sn-glycero-3-phospho-L-serine |
i.e. C6PS, soluble phospholipid, 2 molecules per enzyme molecule, binding to 2 binding sites in sigmoidal fashion with active site labeled enzyme and in hyperbolic fashion with nonlabeled enzyme, binding induces conformaional changes of secondary structure, binding to the tighter of the 2 binding site triggers structural changes which lead to Ca2+-dependent dimer formation, model of sequential binding mechanism |
650585 |
| 3.4.21.6 | Factor V |
- |
683838 |
| 3.4.21.6 | Factor Va |
- |
650585 |
| 3.4.21.6 | Factor Va |
binding site for factor Xa is located at amino acid residues 307-348 of the heavy chain, purified factor Va is not stable during rapid freezing and thawing |
650111 |
| 3.4.21.6 | Factor Va |
part of the prothrombinase complex |
649797 |
| 3.4.21.6 | Factor Va |
part of the prothrombinase enzyme complex |
650336 |
| 3.4.21.6 | Factor Va |
required |
652501 |
| 3.4.21.6 | Factor VIIa |
human plasma factor V activated by thrombin, residues 1-709 and 1546-2196, required for catalytic activity in the prothrombinase complex activating prothrombin to thrombin |
652447 |
| 3.4.21.6 | factor VNN |
factor V cleaved by the venom of the snake Naja nigricollis nigricollis at Asp697, Asp1509, and Asp1514, 2 fragments of MW 100 and 80 kDa, 7% clotting activity compared to factor VIIa |
652447 |
| 3.4.21.6 | factor VNN/IIa |
factor VNN cleaved by alpha-thrombin at Arg1545, 48% clotting activity compared to factor VIIa |
652447 |
