EC Number   |
Cofactor |
Reference |
|---|
    2.8.1.7 | Fe-S center |
- |
762274 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
- |
645615, 645616, 645618, 645619, 645630, 661090, 661091, 672260, 672277, 672753, 702269, 703682, 704679, 705872, 706851, 724238, 724292, 725009, 726016, 726296, 726333, 726388, 727067, 737712, 738600, 738601, 739453, 739655, 760243, 760523, 761068 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
0.8 mol per monomer |
645631 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
adding pyridoxal 5'-phosphate to IscS produces an enzyme that displays in vitro L-cysteine desulfurase activity |
724811 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
dependent on |
724057, 725215, 737375 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
recombinant protein possesses PLP-binding activity, catalytic activity requires pyridoxal 5'-phosphate |
761583 |
| 2.8.1.7 | pyridoxal 5'-phosphate |
the cofactor is covalently attached to the side chain amino group of Lys201 in a deep surface pocket via the formation of an internal aldimine Schiff base |
761791 |
| 2.8.1.7 | pyridoxamine 5'-phosphate |
the enzyme contains pyridoxamine 5'-phosphate which is catalytically inactive in the cysteine desulfurase reaction, leading to a lack of cysteine desulfurase activity |
724811 |
