EC Number |
Cofactor |
Reference |
---|
2.7.13.3 | ATP |
- |
690397, 690950, 692882, 694232, 701785, 701950, 702402, 702733, 702906, 704312, 704324, 704331, 704333, 705134, 705769, 705772, 705782, 705788, 705793, 706173, 706435, 706513, 739983, 740049, 740070, 740082, 740525, 740621, 740624, 740870, 741136, 741222, 741226, 741235, 741283 |
2.7.13.3 | ATP |
DesK displays a compact structure at the ATP-binding pocket: the ATP lid loop is short with no secondary structural organization and becomes ordered upon ATP loading. Sequence conservation mapping onto the molecular surface, semi-flexible protein-protein docking simulations, and structure-based point mutagenesis present a specific domain-domain geometry during autophosphorylation catalysis |
740689 |
2.7.13.3 | ATP |
residue Ser492 resides on the ATP lid, near to the Mg2+ ion that coordinates the gamma-phosphate of ATP in the P4 active site |
740869 |
2.7.13.3 | ATP |
the ATP-binding domain of histidine kinases contains conserved motifs essential for autokinase activity. These include G1 and G2 boxes, which have the characteristic glycine signatures DxGxG and GxGxG, respectively |
740492 |
2.7.13.3 | FAD |
Slr1759-Var I protein contains 0.11-0.26 mM cofactor per 1 mM protein |
701950 |
2.7.13.3 | flavin |
- |
682858 |
2.7.13.3 | flavin |
flavin-containing histidine kinase functions as a photoreceptor, the flavin chromophore, upon illumination, forms a cysteinyl-flavin adduct, which is the signaling state that activates the histidine kinase |
682858 |
2.7.13.3 | flavin |
flavin-containing histidine kinase functions as a photoreceptor, the flavin chromophore, upon illumination, forms a cysteinyl-flavin adduct, which is the signaling state that activates the histidine kinase, regulates Brucella abortus virulence |
682858 |
2.7.13.3 | FMN |
bound to the LovK histidine kinase |
740049 |
2.7.13.3 | GDP |
this kinase is uniquely specific for GTP in the forward and GDP in the reverse reaction. The G1 motif of BA2291 is highly modified from ATP specific histidine kinases, binding structure, modeling, overview |
692901 |