EC Number   |
Cofactor |
Reference |
|---|
   2.7.1.78 | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(1H-imidazol-4-yl)ethyl]piperazine-1,2-dicarboxamide |
- |
642017 |
| 2.7.1.78 | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[2-(1H-imidazol-4-yl)ethyl]piperazine-1,2-dicarboxamide |
best phosphate-donor |
642024 |
| 2.7.1.78 | 4-(3-bromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-N1-cyclohexyl-N2-[3-(1H-imidazol-4-yl)propyl]piperazine-1,2-dicarboxamide |
- |
642017 |
| 2.7.1.78 | ADP |
reverse reaction |
642004, 642009 |
| 2.7.1.78 | ATP |
- |
642017, 642024, 672918, 674594, 675365, 676207, 677100, 695561, 703029, 703399, 704680, 706727, 716975, 722727, 723644 |
| 2.7.1.78 | ATP |
ATP is bound within a crescent-shaped groove formed by the P-loop (15GSSGSGKST23) and an overlying helix-loop-helix Βlid |
723764 |
| 2.7.1.78 | ATP |
best at 2 mM |
642021 |
| 2.7.1.78 | ATP |
dependent on |
642004, 642005, 642006, 642007, 642008, 642009, 642010, 642011, 642012, 642013, 642014, 642015, 642018, 642020, 642021, 642022, 642023, 642025, 642026, 81073, 81075 |
| 2.7.1.78 | ATP |
stabilizes the enzyme in an oligomeric state |
642011 |
| 2.7.1.78 | ATP |
the ATP binding site is defined by the Walker A (P-loop) and B motifs conserved in various kinases, as well as an Asp residue that activates the 5'-OH for attack on the ATP gamma-phosphate |
716975 |
