EC Number   |
Cofactor |
Reference |
|---|
   1.14.99.66 | FAD |
- |
684888, 752748, 753006, 753296, 753388, 753659, 755192 |
| 1.14.99.66 | FAD |
a flavin-containing enzyme |
724316 |
| 1.14.99.66 | FAD |
dependent on |
697909, 745771, 752749, 752795, 753965, 754723, 755238 |
| 1.14.99.66 | FAD |
dependent on, required for catalysis. THe FAD is noncovalently bound at the amine oxidase domain (AOD) |
744347 |
| 1.14.99.66 | FAD |
essentially required |
752640 |
| 1.14.99.66 | FAD |
FAD treatment of cells enables an increase in the amount of intracellular FAD and promotes neuronal differentiation of human neural stem cells derived from fetal brain or from induced pluripotent stem cells. Depression of FAD-dependent histone demethylase, lysine-specific demethylase-1 (LSD1), prevents FAD-induced neuronal differentiation. FAD influx facilitates nuclear localization of LSD1 and its enzymatic activity |
753585 |
| 1.14.99.66 | FAD |
flavoenzyme |
700397 |
| 1.14.99.66 | FAD |
histone demethylation involves the enzyme-bound FAD cofactor |
668605 |
| 1.14.99.66 | FAD |
required |
752646 |
| 1.14.99.66 | FAD |
required for catalysis |
744494 |
