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EC Number Cofactor Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.25more during T4 phage infection, S1 host protein acts as a cofactor of the T4 phage RegB endoribonuclease. S1 binds RNA substrates and promotes cleavage by RegB of the partially structured AG-rich RNAs and unstructured RNA having an 11-nucleotide-conserved sequence. The minimal domain combination required for stimulation of RegB nuclease is D4-D5, whereas the peptide containing all C-terminal domains (D3-D4-D5-D6) stimulates RegB to the same extent as the full-length protein 772310
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