EC Number   |
Cofactor  |
Reference |
|---|
    1.3.98.3 | 4Fe-4S-center |
- |
686237, 687282 |
| 1.3.98.3 | 4Fe-4S-center |
contains one [4Fe-4S]+ cluster per monomer |
685280 |
| 1.3.98.3 | 4Fe-4S-center |
HemN binds a 4Fe-4S cluster through three cysteine residues: Cys-62, Cys-66 and Cys-69, a juxtaposed S-adenosyl-L-methionine coordinates the fourth Fe ion through its amide nitrogen and carboxylate oxygen, detailed binding mode, cofactor geometry required for Radical SAM catalysis |
655340 |
| 1.3.98.3 | 4Fe-4S-center |
requirement, oxygen-sensitive Fe-S cluster, Cys-62, Cys-66 and Cys-69 are part of the conserved CXXXCXXC motif and essential for Fe-S cluster formation and enzyme function, Tyr-56 and His-58 are important for the Fe-S cluster integrity, His-58 may provide the fourth ligand besides the three cysteine residues |
656073 |
| 1.3.98.3 | 4Fe-4S-center |
structure, location and coordination of the cofactor, HemN requires the juxtaposition of the [4Fe-4S] cluster and the cosubstrate S-adenosyl-L-methionine |
658501 |
| 1.3.98.3 | heme |
- |
726009 |
| 1.3.98.3 | heme |
in vivo, HemW occurs as a heme-free cytosolic form, as well as a heme-containing membrane-associated form |
724235 |
| 1.3.98.3 | iron-sulfur centre |
in Sll1876 and Sll1917 |
713258 |
| 1.3.98.3 | NADH |
- |
672473 |
| 1.3.98.3 | NADH |
requires NAD(P)H, higher activity than with NADPH as cofactor |
656073 |
