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Results 1 - 10 of 22 > >>
EC Number
Cofactor
Commentary
Reference
4Fe-4S-center
-
4Fe-4S-center
contains one [4Fe-4S]+ cluster per monomer
4Fe-4S-center
HemN binds a 4Fe-4S cluster through three cysteine residues: Cys-62, Cys-66 and Cys-69, a juxtaposed S-adenosyl-L-methionine coordinates the fourth Fe ion through its amide nitrogen and carboxylate oxygen, detailed binding mode, cofactor geometry required for Radical SAM catalysis
4Fe-4S-center
requirement, oxygen-sensitive Fe-S cluster, Cys-62, Cys-66 and Cys-69 are part of the conserved CXXXCXXC motif and essential for Fe-S cluster formation and enzyme function, Tyr-56 and His-58 are important for the Fe-S cluster integrity, His-58 may provide the fourth ligand besides the three cysteine residues
4Fe-4S-center
structure, location and coordination of the cofactor, HemN requires the juxtaposition of the [4Fe-4S] cluster and the cosubstrate S-adenosyl-L-methionine
heme
-
heme
in vivo, HemW occurs as a heme-free cytosolic form, as well as a heme-containing membrane-associated form
iron-sulfur centre
in Sll1876 and Sll1917
NADH
-
NADH
requires NAD(P)H, higher activity than with NADPH as cofactor
Results 1 - 10 of 22 > >>