EC Number   |
Cofactor |
Reference |
|---|
   1.21.1.1 | FAD |
- |
704369 |
| 1.21.1.1 | Ferredoxin |
- |
733237 |
| 1.21.1.1 | flavin |
a flavin mononucleotide-dependent deiodinase |
733459 |
| 1.21.1.1 | flavin |
dependent on |
733360 |
| 1.21.1.1 | flavin |
presence of a neutral flavin radical during the reaction. Radical is stable and persists at 4°C under aerobic conditions for many days |
704182 |
| 1.21.1.1 | FMN |
- |
726449, 733452, 744171, 744363, 746394 |
| 1.21.1.1 | FMN |
1 mol of FMN per mol of protein |
704368 |
| 1.21.1.1 | FMN |
dependent on |
733237 |
| 1.21.1.1 | FMN |
enzyme is reduced in two successive 1-electron oxidation-reduction steps. The oxidation-reduction potential of the couple semiquinone/fully reduced enzyme is -0.412 V at pH 7 and 25°C. The value for the oxidized/semiquinone couple is -0.190 V at pH 7 and 25°C |
704369 |
| 1.21.1.1 | FMN |
FMN binds non-covalently at the dimer interface established by a helix from each of the two identical subunits involving residues Ser102 and Ser128. Iodotyrosine deiodinase utilizes FMN to maintain iodide homeostasis by reductive deiodination of iodotyrosine. In the absence of an active site ligand, only the oxidized and two-electron-reduced forms of FMN are detected |
734321 |
