EC Number   |
Cofactor |
Reference |
|---|
    1.4.1.13 | NADPH |
- |
391438, 391439, 391440, 391441, 391442, 391443, 391444, 391446, 391447, 391448, 391449, 391450, 391451, 391452, 391453, 391454, 391455, 391456, 391457, 391458, 391459, 391460, 391461, 391462, 391464, 391467, 391468, 391469, 674303, 725401, 725886 |
| 1.4.1.13 | NADPH |
oxidizes NADPH stereospecifically at the 4S position |
391445 |
| 1.4.1.13 | NADPH |
the beta subunit contains the NADPH binding site of the enzyme |
391463, 391465 |
| 1.4.1.13 | NADPH |
the C-terminal potential ADP-binding fold of the beta subunit is the NADPH-binding site of the enzyme |
391466 |
| 1.4.1.13 | [4Fe-4S]-center |
the [4Fe-4S]+1,+2 cluster A displays three Cys and one Glu ligands for the Fe atoms. Residues Cys105 and Cys60 are linked to Fe1 and Fe2, respectively and the Fe3 atom shows bidentate coordination to Glu125 carboxylate, Fe4 is coordinated to Cys99, whose Calpha atom falls 5 A from FAD dimethyl-benzene ring C8 methyl. All Cys ligands to the [4Fe-4S]+1,+2 cluster B (Cys48, Cys51, Cys56, Cys109) are comprised in small subunit GltD loops at the interface with GltB |
763361 |
