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EC Number	pH Minimum	pH Maximum	Commentary	Reference
6.3.2.61	6.8	8.9	the enzyme activity increases markedly with the pH going from 6.8 to 8.3, with a large optimum between 8.3 and 8.9, and then decreases sharply. At physiological pH, the activity is 15% of the maximal level	749873
6.3.2.61	7.5	9.2	pH 7.5: about 45% of maximal activity, pH 9.2: about 80% of maximal activity. When the glutamate concentration is raised to 6 mM, the activity is less dependent on pH, decreasing by only 40% between pH 8.7 and 6.8	749873

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Release 2026.1 (March 2026)