2.7.7.88 | gene L, genomic structure, transcription and replication of the rabies virus (RABV) genome. The negative-strand RABV genome wrapped with the nucleocapsid (N) proteins serves as a template for transcription and replication. The RNA-dependent RNA polymerase (RdRp, the complex between large (L) and (P) phosphoproteins) sequentially transcribes the leader region (Le) and five internal genes (N, P, M, G, and L) in the genome into the leader RNA (LeRNA) and five monocistronic mRNAs with the 5'-cap 1 and 3'-poly(A) structures by the stop-start transcription mechanism |